| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
| Targets |
2'-Hydroxy-4'-methylacetophenone targets mites and ticks, acting as an acaricide. Its mechanism of action is not fully detailed, but as a phenolic compound, it likely disrupts the nervous system or other vital physiological processes in these arthropods. It does not have a classic therapeutic target for human diseases but is of interest for agricultural and veterinary applications as a natural pesticide.
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|---|---|
| ln Vitro |
In vitro, 2'-Hydroxy-4'-methylacetophenone exhibits acaricidal activity. Its efficacy against mites has been demonstrated in studies, suggesting it could be useful as a natural acaricide. Its activity is likely assessed by exposing mites to the compound and measuring mortality or repellency. It is also used as a chemical intermediate in the synthesis of other compounds.
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| ln Vivo |
In vivo, the acaricidal activity of 2'-Hydroxy-4'-methylacetophenone is relevant for controlling mite and tick infestations in agricultural or veterinary settings. Its natural origin makes it an attractive candidate for developing environmentally friendly pesticides. However, it is not used as a therapeutic agent for systemic diseases in humans or animals.
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| Enzyme Assay |
In vitro non-cell assays for 2'-Hydroxy-4'-methylacetophenone are typically not enzyme-based. Its acaricidal activity is assessed by direct contact or fumigation bioassays. The compound is applied to mites or ticks in a controlled environment, and mortality or other adverse effects are recorded over time. These bioassays are used to determine the compound's potency and efficacy.
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| Cell Assay |
In vitro cell-based assays for 2'-Hydroxy-4'-methylacetophenone are not common, as its primary use is as an acaricide rather than a therapeutic agent for mammalian cells. However, its cytotoxicity could be evaluated in mammalian cell lines to assess its safety profile for potential applications where human or animal exposure is a concern.
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| Animal Protocol |
In vivo animal studies for 2'-Hydroxy-4'-methylacetophenone would likely involve testing its acaricidal efficacy in animal models infested with mites or ticks. The compound could be applied topically or administered orally to the host animal, and the reduction in parasite load would be measured. These studies would help to determine its practical utility as a veterinary acaricide.
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| ADME/Pharmacokinetics |
2'-Hydroxy-4'-methylacetophenone has a molecular weight of 150.17 g/mol and a molecular formula of C₉H₁₀O₂. It is a clear liquid with a boiling point of 245 °C and a specific gravity of 1.10. As a small, lipophilic molecule, it is expected to be well-absorbed if ingested and to penetrate the exoskeleton of arthropods. Detailed pharmacokinetic data are not widely published.
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| Toxicity/Toxicokinetics |
The toxicity of 2'-Hydroxy-4'-methylacetophenone is not extensively detailed in the provided search results. As a natural phenolic compound, it is likely to have moderate toxicity, and its safety for non-target organisms would need to be evaluated. Standard laboratory safety precautions should be followed when handling the compound.
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| References |
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| Additional Infomation |
Reports have indicated that Ze Lan and Angelica dahurica contain 2'-hydroxy-4'-methylacetophenone, and relevant data is available for reference.
2'-Hydroxy-4'-methylacetophenone is a phenolic compound isolated from Angelica koreana roots with acaricidal activity. It is also known as 2′-Hydroxy-4′-methylacetophenone. It is used in research as a natural acaricide against mites and ticks and as a chemical intermediate. It is not approved for therapeutic use in humans. |
| Molecular Formula |
C9H10O2
|
|---|---|
| Molecular Weight |
150.1745
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| Exact Mass |
150.068
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| CAS # |
6921-64-8
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| PubChem CID |
81338
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| Appearance |
Colorless to light yellow liquid
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| Density |
1.08 g/mL at 25 °C(lit.)
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| Boiling Point |
245 °C(lit.)
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| Melting Point |
45-48ºC
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| Flash Point |
>230 °F
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| Index of Refraction |
n20/D 1.565(lit.)
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| LogP |
1.903
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
11
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| Complexity |
154
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O([H])C1C([H])=C(C([H])([H])[H])C([H])=C([H])C=1C(C([H])([H])[H])=O
|
| InChi Key |
LYKDOWJROLHYOT-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H10O2/c1-6-3-4-8(7(2)10)9(11)5-6/h3-5,11H,1-2H3
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| Chemical Name |
1-(2-hydroxy-4-methylphenyl)ethanone
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~665.91 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (16.65 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (16.65 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (16.65 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.6591 mL | 33.2956 mL | 66.5912 mL | |
| 5 mM | 1.3318 mL | 6.6591 mL | 13.3182 mL | |
| 10 mM | 0.6659 mL | 3.3296 mL | 6.6591 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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