| Size | Price | |
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| Other Sizes |
| Targets |
2-(Dimethylamino)acetaldehyde HCl has no direct pharmacological target. It is not intended to interact with receptors, enzymes, or ion channels. In biological systems, the aldehyde group can react with amines and other nucleophiles, potentially leading to non-specific interactions. Its primary use is in chemical synthesis for the preparation of drug candidates and other compounds.
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|---|---|
| ln Vitro |
In vitro, 2-(dimethylamino)acetaldehyde HCl does not exhibit any specific biological activity. It is used as a precursor in the synthesis of various N-containing heterocycles. The compound may be toxic to cells due to the reactive aldehyde group, but no specific cytotoxicity data are available. It is not used in cell-based assays for pharmacological studies.
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| ln Vivo |
2-(Dimethylamino)acetaldehyde HCl is not used in in vivo pharmacological studies. It is not administered to animals as a therapeutic agent. The compound is used as a chemical reagent and is not intended for biological testing. No in vivo efficacy or safety data are available for this compound.
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| Enzyme Assay |
No specific enzyme or receptor binding assay is applicable to 2-(dimethylamino)acetaldehyde HCl. In analytical chemistry, the compound is characterized by HPLC and NMR spectroscopy. The compound is typically analyzed using a reversed-phase C18 column with a mobile phase containing 0.1% TFA in water/acetonitrile. Purity is assessed by HPLC at 210 nm. The compound is also used as a chemical standard.
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| Cell Assay |
2-(Dimethylamino)acetaldehyde HCl is not used in in vitro cell-based assays for biological studies. If tested, the compound would be highly cytotoxic due to the reactive aldehyde group. It is not suitable for cell culture experiments without derivatization. The compound may be used in chemical biology studies as a building block for the synthesis of probes.
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| Animal Protocol |
2-(Dimethylamino)acetaldehyde HCl is not used in in vivo animal experiments. It is a chemical intermediate and is not intended for administration to animals. No animal studies investigating the biological effects of this compound have been reported. It is handled with standard laboratory safety precautions.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 2-(dimethylamino)acetaldehyde HCl are not available. The compound is not a drug, and no studies on absorption, distribution, metabolism, or excretion have been conducted. If administered systemically, the aldehyde group would likely react rapidly with cellular nucleophiles, and the compound would be metabolized or cleared quickly.
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| Toxicity/Toxicokinetics |
2-(Dimethylamino)acetaldehyde HCl is a hazardous chemical. It is corrosive and can cause severe skin and eye irritation. The compound is toxic if inhaled or swallowed (oral LD50 estimated to be 100-500 mg/kg based on related compounds). No data on carcinogenicity, mutagenicity, or reproductive toxicity are available. It should be handled in a fume hood with appropriate personal protective equipment.
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| References | |
| Additional Infomation |
2-(Dimethylamino)acetaldehyde HCl is a white to off-white crystalline solid. It is highly soluble in water and ethanol. It has a molecular weight of 139.6 g/mol. The compound is used as an intermediate in the synthesis of antihistamines, local anesthetics, and other pharmaceuticals. It is also used in the production of agrochemicals and dyes. The compound is not approved for human or veterinary use.
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| Molecular Formula |
C₄H₁₀CLNO
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|---|---|
| Molecular Weight |
123.58
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| Exact Mass |
123.045
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| CAS # |
125969-54-2
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| Related CAS # |
2-(Dimethylamino)acetaldehyde;52334-92-6
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| PubChem CID |
13908802
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| Appearance |
White to off-white solid powder
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| LogP |
0.548
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
7
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| Complexity |
42.8
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CN(C)CC=O.Cl
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| InChi Key |
VUFMJROCMFQILX-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C4H9NO.ClH/c1-5(2)3-4-6;/h4H,3H2,1-2H3;1H
|
| Chemical Name |
2-(dimethylamino)acetaldehyde;hydrochloride
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| Synonyms |
2(Dimethylamino)acetaldehyde HCl; 2 (Dimethylamino)acetaldehyde HCl
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~62.5 mg/mL (~505.75 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (404.60 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.0919 mL | 40.4596 mL | 80.9192 mL | |
| 5 mM | 1.6184 mL | 8.0919 mL | 16.1838 mL | |
| 10 mM | 0.8092 mL | 4.0460 mL | 8.0919 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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