Size | Price | Stock | Qty |
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100mg |
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Other Sizes |
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ln Vitro |
Selectivity for LOXL2 and other hydroxylamine oxidases (MAO-A, MAO-B, and SSAO) of 2-chloropyridin-4-yl)methylamine hydrochloride derivative. The IC50 of 2-chloropyridine)-4-yl)methanamine hydrochloride in the human whole blood LOXL2 assay was 1.45 μM and 126 nM in the absence of saline protein. The selectivity of 2-chloropyridin-4-yl) methylamine hydrochloride for LOXL2+BSA (IC50=190 nM) is 31 times higher than that of LOX+BSA (IC50=5.91μM). When tested at 30 μM against a panel of strong LTQ AO enzymes (MAO-A, MAO-B, and SSAO), LOXL2-IN-1 was found to be inactive. Different CYP enzymes (CYP 3A4, 2C9, and 2D6) can be inhibited by 2-chloropyridin-4-yl methylamine hydrochloride, with a maximal IC50 surpassing 30 μM [1].
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References |
[1]. Hutchinson JH, et al. Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS Med Chem Lett. 2017 Mar 1;8(4):423-427.
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Molecular Formula |
C6H8CL2N2
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Molecular Weight |
179.0471
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CAS # |
916210-98-5
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SMILES |
ClC1C([H])=C(C([H])=C([H])N=1)C([H])([H])N([H])[H].Cl[H]
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ≥ 50 mg/mL (~279.25 mM)
DMSO : ≥ 33 mg/mL (~184.31 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (558.50 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 5.5850 mL | 27.9252 mL | 55.8503 mL | |
5 mM | 1.1170 mL | 5.5850 mL | 11.1701 mL | |
10 mM | 0.5585 mL | 2.7925 mL | 5.5850 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.