| Size | Price | Stock | Qty |
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| 1mg |
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| 5mg |
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| 10mg |
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| Other Sizes |
2-Chlorohexadecanoic acid is a novel inflammatory lipid mediator that interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.
| ln Vitro |
2-Chlorohexadecanoic acid (2-ClHA; 10 μM; 4, 6 h) caused eIF2α phosphorylation to begin 4 hours after treatment, although the overall amount of eIF2α did not alter during the incubation of hCMEC/D3 cells. The eIF2α target gene ATF4 can be expressed more when 2-chlorohexadecanoic acid is present [1]. When cells were treated with 2-chlorohexadecanoic acid (25 µM) for 30 minutes, the FRET ratio signal of ERAT decreased by 40%, indicating a considerable decrease in [ATP]ER [1].
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| References |
| Molecular Formula |
C16H31CLO2
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|---|---|
| Molecular Weight |
290.869144678116
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| Exact Mass |
290.201
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| CAS # |
19117-92-1
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| Related CAS # |
2-Chlorohexadecanoic acid; 19117-92-1
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| PubChem CID |
11087559
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| Appearance |
White to off-white solid
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| LogP |
5.769
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
14
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| Heavy Atom Count |
19
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| Complexity |
207
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| Defined Atom Stereocenter Count |
0
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| SMILES |
CCCCCCCCCCCCCCC(C(=O)O)Cl
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| InChi Key |
LDQUHRSWFMWRNG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H31ClO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(17)16(18)19/h15H,2-14H2,1H3,(H,18,19)
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| Chemical Name |
2-chlorohexadecanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~20 mg/mL (~68.8 mM; with ultrasonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2 mg/mL (6.88 mM) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Clear solution; with ultrasonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (20.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2 mg/mL (6.88 mM) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (20.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4380 mL | 17.1898 mL | 34.3796 mL | |
| 5 mM | 0.6876 mL | 3.4380 mL | 6.8759 mL | |
| 10 mM | 0.3438 mL | 1.7190 mL | 3.4380 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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