| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
2-Aminoquinoline does not have a well-defined specific pharmacological target. As a fragment molecule, it serves as an important scaffold for medicinal chemistry and drug discovery. It is used for molecular linking, expansion, and modification in the design of new pharmaceutical compounds.
|
|---|---|
| ln Vitro |
In vitro, 2-Aminoquinoline is used as a research chemical and scaffold for drug discovery. It serves as a building block for the synthesis of various bioactive compounds. Its quinoline core is found in many natural products and pharmaceuticals.
|
| ln Vivo |
In vivo data for 2-Aminoquinoline are limited in the available literature. As a research chemical and scaffold, it is primarily used in medicinal chemistry and drug discovery rather than as a therapeutic agent itself.
|
| Enzyme Assay |
2-Aminoquinoline is a fragment molecule that can be used in various biochemical assays for drug discovery. Its physicochemical properties, including pKa (3.43 at 20°C) and solubility, can be characterized. It can be used in binding studies to identify new drug candidates.
|
| Cell Assay |
In vitro cell experiments with 2-Aminoquinoline are limited as it is primarily used as a synthetic intermediate. It can be used in cell-based assays to evaluate the activity of compounds derived from it.
|
| Animal Protocol |
In vivo animal studies with 2-Aminoquinoline are limited as it is primarily used as a research chemical and scaffold. It is not typically administered as a therapeutic agent in animal models.
|
| ADME/Pharmacokinetics |
2-Aminoquinoline has a molecular weight of 144.17 and a molecular formula of C₉H₈N₂. It has a melting point of 127-132°C and is stable under normal temperatures and pressures. It is soluble in water.
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| Toxicity/Toxicokinetics |
2-Aminoquinoline is considered safe for research use at typical concentrations. As a research chemical, it is intended for laboratory use only and not for human consumption. The compound should be handled under standard laboratory safety practices.
|
| References | |
| Additional Infomation |
1,2-Dihydroquinoline-2-imine is an aminoquinoline. It has been reported that 2-aminoquinoline exists in Leucopaxillus albissimus, and relevant data are available for reference.
2-Aminoquinoline is a fragment molecule with CAS number 580-22-3. It serves as an important scaffold for molecular linking, expansion, and modification in drug discovery. It is used for the design and screening of novel drug candidates and in drug synthesis. |
| Molecular Formula |
C9H8N2
|
|---|---|
| Molecular Weight |
144.1732
|
| Exact Mass |
144.068
|
| CAS # |
580-22-3
|
| PubChem CID |
11379
|
| Appearance |
Off-white to light yellow solid powder
|
| Density |
1.2±0.1 g/cm3
|
| Boiling Point |
304.9±15.0 °C at 760 mmHg
|
| Melting Point |
125 °C
|
| Flash Point |
163.6±7.6 °C
|
| Vapour Pressure |
0.0±0.6 mmHg at 25°C
|
| Index of Refraction |
1.708
|
| LogP |
1.73
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
0
|
| Heavy Atom Count |
11
|
| Complexity |
136
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
GCMNJUJAKQGROZ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C9H8N2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H,(H2,10,11)
|
| Chemical Name |
quinolin-2-amine
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~693.63 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (17.34 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (17.34 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (17.34 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.9363 mL | 34.6813 mL | 69.3626 mL | |
| 5 mM | 1.3873 mL | 6.9363 mL | 13.8725 mL | |
| 10 mM | 0.6936 mL | 3.4681 mL | 6.9363 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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