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| Other Sizes |
| Targets |
2-Amino-1-phenylethanol targets the sympathetic nervous system. As a structural analog of noradrenaline, it may interact with adrenergic receptors, mimicking the effects of endogenous catecholamines. Its vasoconstrictor activity is consistent with alpha-adrenergic receptor agonism, leading to the constriction of blood vessels and reduction of blood flow in topical applications.
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| ln Vitro |
In vitro, 2-Amino-1-phenylethanol has been reported to exist in various organisms and is a simple amine found in the brain. As a structural analog of noradrenaline, it may exhibit sympathomimetic activity, including vasoconstriction. Its in vitro activities are characteristic of compounds that interact with the sympathetic nervous system.
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| ln Vivo |
In vivo, 2-Amino-1-phenylethanol is used as a topical vasoconstrictor. It may regulate sympathetic nerve function. When applied topically, it constricts blood vessels, reducing local blood flow and edema. Its systemic effects are limited due to its topical route of administration.
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| Enzyme Assay |
In vitro assays for 2-Amino-1-phenylethanol are conducted to evaluate its vasoconstrictor activity. Isolated blood vessels (e.g., rat aorta) are used to assess contractile responses to the compound. Tissues are mounted in organ baths and exposed to varying concentrations of the compound (typically 0.1 µM to 1 mM). Isometric tension is measured to determine the potency and efficacy of vasoconstriction.
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| Cell Assay |
2-Amino-1-phenylethanol is not typically used in mammalian cell-based assays. Cytotoxicity assays may be conducted in relevant cell lines to assess potential toxicity.
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| Animal Protocol |
In vivo animal studies for 2-Amino-1-phenylethanol are limited, as it is primarily used as a topical vasoconstrictor. Studies would involve topical application to assess local vasoconstrictor effects in animal models.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 2-Amino-1-phenylethanol are limited. The compound has a molecular weight of 137.18 and a molecular formula of C₈H₁₁NO. As a small, polar molecule, it is expected to be absorbed following topical application and may undergo metabolism via monoamine oxidase and other enzymes.
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| Toxicity/Toxicokinetics |
2-Amino-1-phenylethanol is used as a topical vasoconstrictor and is generally well-tolerated at recommended concentrations. Overuse may lead to local tissue ischemia or rebound vasodilation. Standard safety precautions apply.
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| References | |
| Additional Infomation |
Phenylethanolamine is the simplest member of the phenylethanolamine class of compounds. It is a structure of 2-aminoethanol with a phenyl substituent at the 1-position and is the parent compound of the phenylethanolamine class. It is a human metabolite and the conjugate base of phenylethanolamine. 2-Hydroxyphenethylamine is a metabolite found or produced in Escherichia coli (K12 strain, MG1655 strain). 2-Amino-1-phenylethanol has been reported to exist in patchouli, honeybees, and other organisms with relevant data. It is a simple amine found in the brain and may regulate sympathetic nerve function. Its derivatives are adrenergic agonists and antagonists. It is also used in the chemical industry.
2-Amino-1-phenylethanol (phenylethanolamine) is a structural analog of noradrenaline used as a topical vasoconstrictor. It has a molecular weight of 137.18 and formula C₈H₁₁NO. It is not a major pharmaceutical drug. |
| Molecular Formula |
C8H11NO
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|---|---|
| Molecular Weight |
137.1790
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| Exact Mass |
137.084
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| CAS # |
7568-93-6
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| PubChem CID |
1000
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| Appearance |
White to yellow solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
286.9±13.0 °C at 760 mmHg
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| Melting Point |
56-58 °C(lit.)
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| Flash Point |
151.4±10.5 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.600
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| LogP |
0.82
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
10
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| Complexity |
89.3
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
ULSIYEODSMZIPX-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H11NO/c9-6-8(10)7-4-2-1-3-5-7/h1-5,8,10H,6,9H2
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| Chemical Name |
2-amino-1-phenylethanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~728.97 mM)
H2O : < 0.1 mg/mL |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (18.22 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (18.22 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (18.22 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.2897 mL | 36.4485 mL | 72.8969 mL | |
| 5 mM | 1.4579 mL | 7.2897 mL | 14.5794 mL | |
| 10 mM | 0.7290 mL | 3.6448 mL | 7.2897 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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