| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
The primary targets of 2-Methoxybenzaldehyde include bacterial and fungal pathogens. The compound exhibits antibacterial and antifungal activity, making it effective against various microbial pathogens. It is extracted from cinnamon essential oil and has been characterized for its antimicrobial properties. The compound does not have a defined receptor target but exerts its effects through direct antimicrobial mechanisms.
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|---|---|
| ln Vitro |
In vitro, 2-Methoxybenzaldehyde demonstrates antibacterial and antifungal activity. As a compound extracted from cinnamon essential oil, it has been characterized for its antimicrobial properties. The antimicrobial activity is concentration-dependent and has been demonstrated in standard microbiological assays. The compound's activity is attributed to its ability to disrupt microbial cell membranes and inhibit microbial growth.
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| ln Vivo |
In vivo activity of 2-Methoxybenzaldehyde has not been extensively characterized. As a natural product with antimicrobial effects, it has potential for protecting against microbial infections. However, detailed in vivo pharmacokinetic and pharmacodynamic studies are limited. The compound is primarily studied for its antimicrobial properties in vitro.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays for 2-Methoxybenzaldehyde typically involve antimicrobial susceptibility testing. Bacterial and fungal strains are cultured in appropriate media and treated with serial dilutions of the compound. The minimum inhibitory concentration (MIC) is determined after 24-48 hours of incubation at 37°C using the broth microdilution method. Cell viability is assessed by measuring optical density at 600 nm or by colony counting on agar plates.
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| Cell Assay |
In vitro cellular assays for 2-Methoxybenzaldehyde involve testing its antimicrobial activity against bacterial and fungal pathogens. Microbial cultures are grown in appropriate media and treated with serial dilutions of 2-Methoxybenzaldehyde (0.1-1000 µg/mL). After 24-48 hours of incubation, the optical density is measured to determine microbial growth inhibition. The minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) are calculated from the dose-response curves.
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| Animal Protocol |
In vivo animal studies for 2-Methoxybenzaldehyde are limited, as the compound is primarily studied in vitro. For antimicrobial efficacy testing, animal models of infection could be used. Animals would be treated with 2-Methoxybenzaldehyde via oral or topical administration, and microbial burden in target tissues would be assessed. However, detailed in vivo protocols are not well established in the available literature.
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| ADME/Pharmacokinetics |
The pharmacokinetic properties of 2-Methoxybenzaldehyde include a molecular weight of 136.15 and a molecular formula of C₈H₈O₂. The compound appears as a colorless to light yellow powder with a purity of ≥98%. It is intended for research use only and has not been approved for clinical use. Detailed pharmacokinetic parameters such as half-life, oral bioavailability, and tissue distribution are not well characterized in the available literature.
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| Toxicity/Toxicokinetics |
The toxicity profile of 2-Methoxybenzaldehyde has not been extensively characterized. As a natural product, it is generally considered to have low toxicity. Standard toxicity studies would include assessment of acute oral toxicity, dermal irritation, and repeated-dose toxicity in animal models. The compound is intended for research use only and is not approved for clinical use.
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| References |
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| Additional Infomation |
2-Methoxybenzaldehyde is a carbonyl compound.
2-Methoxybenzaldehyde (CAS 135-02-4) has a molecular formula of C₈H₈O₂ and a molecular weight of 136.15. It is extracted from cinnamon essential oil and has antibacterial and antifungal activity. The compound appears as a colorless to light yellow powder with a purity of ≥98%. It is intended for research use only and is not approved for clinical use. |
| Molecular Formula |
C8H8O2
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|---|---|
| Molecular Weight |
136.15
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| Exact Mass |
136.052
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| CAS # |
135-02-4
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| Related CAS # |
2-Methoxybenzaldehyde-d3;56248-49-8
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| PubChem CID |
8658
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| Appearance |
Colorless to light yellow <34°C powder,>40°C liquid
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
243.5±0.0 °C at 760 mmHg
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| Melting Point |
34-40 °C(lit.)
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| Flash Point |
117.8±0.0 °C
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| Vapour Pressure |
0.0±0.4 mmHg at 25°C
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| Index of Refraction |
1.547
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| LogP |
1.72
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| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
10
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| Complexity |
112
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
O(C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])=O
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| InChi Key |
PKZJLOCLABXVMC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H8O2/c1-10-8-5-3-2-4-7(8)6-9/h2-6H,1H3
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| Chemical Name |
2-methoxybenzaldehyde
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 100 mg/mL (734.48 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (18.36 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (18.36 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (18.36 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.3448 mL | 36.7242 mL | 73.4484 mL | |
| 5 mM | 1.4690 mL | 7.3448 mL | 14.6897 mL | |
| 10 mM | 0.7345 mL | 3.6724 mL | 7.3448 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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