| Size | Price | |
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| Other Sizes |
| Targets |
The primary targets of 2-Ethyl-6-methylphenol include bacterial pathogens and insects. The compound exhibits insecticidal and bactericidal activities. It is extracted from the oncogenic neutral subfraction of cigarette smoke condensate and has been characterized for its antimicrobial and insecticidal properties. The compound does not have a defined receptor target but exerts its effects through direct antimicrobial and insecticidal mechanisms.
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| ln Vitro |
In vitro, 2-Ethyl-6-methylphenol demonstrates insecticidal and bactericidal activities. As an alkylphenol extracted from cigarette smoke condensate, it has been characterized for its antimicrobial and insecticidal properties. The activities are concentration-dependent and have been demonstrated in standard bioassays. The compound's mechanism of action is attributed to its ability to disrupt cell membranes and interfere with microbial and insect physiology.
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| ln Vivo |
In vivo activity of 2-Ethyl-6-methylphenol has not been extensively characterized. As a natural product with insecticidal and bactericidal effects, it has potential for protecting against microbial infections and insect pests. However, detailed in vivo pharmacokinetic and pharmacodynamic studies are limited. The compound is primarily studied for its antimicrobial and insecticidal properties in vitro.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays for 2-Ethyl-6-methylphenol typically involve antimicrobial and insecticidal activity testing. Bacterial strains and insect models are treated with serial dilutions of the compound. The minimum inhibitory concentration (MIC) for bacteria and the lethal concentration (LC₅₀) for insects are determined. The compound demonstrates concentration-dependent antimicrobial and insecticidal activity.
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| Cell Assay |
In vitro cellular assays for 2-Ethyl-6-methylphenol involve testing its antimicrobial activity against bacterial pathogens. Bacterial cultures are grown in appropriate media and treated with serial dilutions of 2-Ethyl-6-methylphenol (0.1-1000 µg/mL). After 24 hours of incubation, the optical density at 600 nm is measured to determine bacterial growth inhibition. The minimum inhibitory concentration (MIC) is calculated from the dose-response curves.
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| Animal Protocol |
In vivo animal studies for 2-Ethyl-6-methylphenol are limited, as the compound is primarily studied in vitro. For insecticidal efficacy testing, insect models (e.g., mosquitoes, agricultural pests) could be used. Insects would be exposed to 2-Ethyl-6-methylphenol at various concentrations, and mortality rates would be assessed. However, detailed in vivo protocols are not well established in the available literature.
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| ADME/Pharmacokinetics |
The pharmacokinetic properties of 2-Ethyl-6-methylphenol include a molecular weight of 136.19 and a molecular formula of C₉H₁₂O. The compound is intended for research use only and has not been approved for clinical use. Detailed pharmacokinetic parameters such as half-life, oral bioavailability, and tissue distribution are not well characterized in the available literature.
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| Toxicity/Toxicokinetics |
The toxicity profile of 2-Ethyl-6-methylphenol has not been extensively characterized. As an alkylphenol, it may have moderate toxicity. Standard toxicity studies would include assessment of acute oral toxicity, dermal irritation, and repeated-dose toxicity in animal models. The compound is intended for research use only and is not approved for clinical use.
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| References |
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| Additional Infomation |
6-Ethyl-o-cresol is a type of hydroxytoluene.
2-Ethyl-6-methylphenol (CAS 1687-64-5) has a molecular formula of C₉H₁₂O and a molecular weight of 136.19. It is an alkylphenol extracted from the oncogenic neutral subfraction of cigarette smoke condensate and exhibits insecticidal and bactericidal activities. It is intended for research use only and is not approved for clinical use. |
| Molecular Formula |
C9H12O
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|---|---|
| Molecular Weight |
136.19
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| Exact Mass |
136.089
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| CAS # |
1687-64-5
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| Related CAS # |
25750-50-9
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| PubChem CID |
519333
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| Appearance |
Light yellow to yellow liquid
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| Density |
0.994g/cm3
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| Boiling Point |
209.8ºC at 760mmHg
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| Flash Point |
90.7ºC
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| Vapour Pressure |
0.137mmHg at 25°C
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| Index of Refraction |
1.531
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| LogP |
2.263
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
1
|
| Heavy Atom Count |
10
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| Complexity |
101
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O([H])C1=C(C([H])([H])[H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])[H]
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| InChi Key |
CIRRFAQIWQFQSS-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H12O/c1-3-8-6-4-5-7(2)9(8)10/h4-6,10H,3H2,1-2H3
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| Chemical Name |
2-ethyl-6-methylphenol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 100 mg/mL (734.27 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (18.36 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (18.36 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (18.36 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.3427 mL | 36.7134 mL | 73.4268 mL | |
| 5 mM | 1.4685 mL | 7.3427 mL | 14.6854 mL | |
| 10 mM | 0.7343 mL | 3.6713 mL | 7.3427 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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