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|---|---|---|
| Other Sizes |
| Targets |
2,6-Dimethylhydroquinone does not have a well-defined pharmacological target, as it is primarily a chemical intermediate and metabolite. It has antioxidant and redox-active properties, suggesting it may interact with reactive oxygen species and redox-sensitive signaling pathways. However, its specific molecular targets have not been fully characterized. It is not used as a therapeutic agent.
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|---|---|
| ln Vitro |
2,6-Dimethylhydroquinone demonstrates in vitro antioxidant activity due to its redox-active properties. It can scavenge free radicals and protect cells from oxidative stress. The compound's hydroquinone structure is characteristic of many antioxidants. However, detailed in vitro activity data, including EC50 values for antioxidant activity, are limited. It is primarily used as a chemical intermediate in organic synthesis.
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| ln Vivo |
In vivo activity of 2,6-Dimethylhydroquinone is related to its role as an endogenous metabolite. It is metabolized by the body and excreted. The compound's antioxidant properties suggest it may have beneficial effects in vivo, but comprehensive in vivo studies evaluating its pharmacokinetic properties, efficacy, and safety are limited. It is not used therapeutically.
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| Enzyme Assay |
In vitro enzyme/receptor binding experiments for 2,6-Dimethylhydroquinone are not typical, as it is a chemical intermediate rather than a pharmacologically active compound. Studies may involve measuring its antioxidant activity using assays such as DPPH radical scavenging or ABTS assays. Its chemical properties are characterized using standard analytical methods such as HPLC and mass spectrometry. The compound is also used as a reference standard in analytical chemistry.
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| Cell Assay |
In vitro cellular experiments for 2,6-Dimethylhydroquinone typically involve studying its antioxidant effects on cell lines. Cells are treated with the compound, and markers of oxidative stress, such as reactive oxygen species levels or lipid peroxidation, are measured. The compound's effects on cell viability and proliferation are also assessed. Cytotoxicity assays are performed to ensure that the observed effects are not due to cell death.
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| Animal Protocol |
In vivo animal experiments for 2,6-Dimethylhydroquinone are not typical, as it is a chemical intermediate rather than a drug candidate. Studies may involve administering the compound to animals to study its metabolism or its antioxidant effects. However, comprehensive in vivo studies evaluating its pharmacokinetic properties are limited. The compound's antioxidant properties warrant further investigation in animal models.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of 2,6-Dimethylhydroquinone have not been extensively characterized. With a molecular weight of 138.17, the compound is expected to have moderate lipophilicity. It has a melting point of 154°C and a boiling point of 193.57°C (rough estimate). Detailed pharmacokinetic studies are limited. The compound's physicochemical properties are typical of hydroquinones.
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| Toxicity/Toxicokinetics |
Toxicological data for 2,6-Dimethylhydroquinone are limited. As a hydroquinone, it may cause skin and eye irritation and may be harmful if ingested. The compound should be handled with care, and standard safety protocols for handling phenols and hydroquinones should be followed, including the use of personal protective equipment and working in a well-ventilated area. The toxicological properties of this substance have not been fully investigated.
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| Additional Infomation |
2,6-Dimethyl-1,4-benzenediol is a hydroquinone compound. It has been reported that 2,6-dimethylhydroquinone has been detected in Macrococculus pomiferus, and relevant data are available for reference.
2,6-Dimethylhydroquinone is a research chemical that has not entered clinical trials or received regulatory approval for therapeutic use. It is primarily used as a chemical intermediate in organic synthesis, material chemistry, and biomedical research. The compound is also an endogenous metabolite and has antioxidant and redox-active properties. It is also known as 2,6-dimethyl-1,4-benzenediol. Further research is needed to explore its potential therapeutic applications. |
| Molecular Formula |
C₈H₁₀O₂
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|---|---|
| Molecular Weight |
138.16
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| Exact Mass |
138.068
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| CAS # |
654-42-2
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| PubChem CID |
69560
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| Appearance |
Off-white to light brown solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
284.6±35.0 °C at 760 mmHg
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| Melting Point |
154°C
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| Flash Point |
141.1±20.5 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.582
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| LogP |
1.56
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
10
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| Complexity |
102
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
SGWZVZZVXOJRAQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C8H10O2/c1-5-3-7(9)4-6(2)8(5)10/h3-4,9-10H,1-2H3
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| Chemical Name |
2,6-dimethylbenzene-1,4-diol
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| Synonyms |
2,6Dimethylhydroquinone; 2,6 Dimethylhydroquinone
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~25 mg/mL (~180.95 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (18.09 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (18.09 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (18.09 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 7.2380 mL | 36.1899 mL | 72.3798 mL | |
| 5 mM | 1.4476 mL | 7.2380 mL | 14.4760 mL | |
| 10 mM | 0.7238 mL | 3.6190 mL | 7.2380 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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