| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
| Targets |
2,6-Dichloroquinone-4-chloroimide is a chemical reagent and does not have a biological target. It is used in analytical chemistry to detect the presence of phenols and amines through colorimetric reactions. It reacts with these compounds to produce colored products.
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|---|---|
| ln Vitro |
2,6-Dichloroquinone-4-chloroimide is used in vitro as a reagent in spot tests and as a chromatographic spray reagent. It is used to detect phenols, antioxidants, and some primary and secondary amines on silica gel chromatographic plates. It reacts with these compounds to form colored spots.
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| ln Vivo |
2,6-Dichloroquinone-4-chloroimide is not used in vivo. Its applications are limited to in vitro analytical chemistry.
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| Enzyme Assay |
In vitro, the reagent is used as a spray reagent on thin-layer chromatography (TLC) plates. After developing the TLC plate, it is sprayed with a solution of 2,6-Dichloroquinone-4-chloroimide. The presence of phenols or amines is indicated by the formation of colored spots.
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| Cell Assay |
2,6-Dichloroquinone-4-chloroimide is not used in cell-based assays. Its use is restricted to analytical chemistry applications.
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| Animal Protocol |
2,6-Dichloroquinone-4-chloroimide is not used in in vivo animal experiments. Its use is restricted to in vitro applications.
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| ADME/Pharmacokinetics |
2,6-Dichloroquinone-4-chloroimide has a molecular weight of 210.44 and formula C6H2Cl3NO. It is a yellow crystalline solid. It is soluble in organic solvents such as ether and chloroform, and in ethanol and dilute alkaline solutions, but insoluble in water. Melting point: 180-182°C. Purity: 99%.
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| Toxicity/Toxicokinetics |
2,6-Dichloroquinone-4-chloroimide is toxic. The LD50 (mouse, intraperitoneal) is 20 mg/kg. It may decompose upon heating and is explosive. It is a skin, eye, and respiratory irritant. It is for research use only.
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| References |
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| Additional Infomation |
2,6-Dichloroquinone-4-chloroimide is also known as Gibbs Reagent. It is used as a spot test and chromatographic spray reagent for phenols and amines.
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| Molecular Formula |
C6H2NOCL3
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|---|---|
| Molecular Weight |
210.44518
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| Exact Mass |
208.92
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| CAS # |
101-38-2
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| PubChem CID |
7556
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| Appearance |
Light yellow to brown solid powder
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| Density |
1.6±0.1 g/cm3
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| Boiling Point |
262.3±50.0 °C at 760 mmHg
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| Melting Point |
65-67 °C(lit.)
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| Flash Point |
104.3±19.3 °C
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| Vapour Pressure |
0.0±0.5 mmHg at 25°C
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| Index of Refraction |
1.612
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| LogP |
1.64
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
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| Rotatable Bond Count |
0
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| Heavy Atom Count |
11
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| Complexity |
266
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
YHUMTHWQGWPJOQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C6H2Cl3NO/c7-4-1-3(10-9)2-5(8)6(4)11/h1-2H
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| Chemical Name |
2,6-dichloro-4-chloroiminocyclohexa-2,5-dien-1-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~475.17 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (11.88 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.7517 mL | 23.7586 mL | 47.5172 mL | |
| 5 mM | 0.9503 mL | 4.7517 mL | 9.5034 mL | |
| 10 mM | 0.4752 mL | 2.3759 mL | 4.7517 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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