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| Other Sizes |
| Targets |
2,6-Dichlorodiphenylamine targets Candida albicans, exhibiting antifungal activity against this pathogen. As a structural analog of diclofenac sodium, it may also interact with cyclooxygenase (COX) enzymes, although its primary reported activity is antifungal. The compound's mechanism of action against C. albicans involves disruption of fungal cell growth.
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| ln Vitro |
2,6-Dichlorodiphenylamine demonstrates in vitro anti-Candida albicans activity. Its activity is typically assessed in antifungal susceptibility assays against C. albicans cultures. The compound's activity is concentration-dependent, and minimum inhibitory concentration (MIC) values can be determined from dose-response curves.
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| ln Vivo |
In vivo activity of 2,6-dichlorodiphenylamine has not been extensively documented. Its in vitro anti-Candida albicans activity suggests potential for in vivo efficacy in models of Candida infection. Further in vivo studies are needed to evaluate its pharmacokinetic properties, antifungal efficacy, and safety profile.
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| Enzyme Assay |
In vitro enzyme assays for 2,6-dichlorodiphenylamine are not typically performed, as the compound's primary reported activity is antifungal rather than enzyme inhibition. Its activity against C. albicans is assessed using standard antifungal susceptibility assays, where the compound's ability to inhibit fungal growth is measured.
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| Cell Assay |
In vitro cellular assays for 2,6-dichlorodiphenylamine involve culturing Candida albicans cells in the presence of varying concentrations of the compound. Antifungal activity is assessed by measuring inhibition of growth using optical density measurements or colony counting. Minimum inhibitory concentration (MIC) values are determined as the lowest concentration that inhibits visible fungal growth.
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| Animal Protocol |
In vivo animal experiments for 2,6-dichlorodiphenylamine are not extensively documented. If used in animal models of Candida infection, typical protocols would involve administering the compound to infected animals and evaluating efficacy by measuring fungal load in tissues or clinical outcomes. Further studies are needed to characterize its in vivo activity.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for 2,6-dichlorodiphenylamine are limited. As a structural analog of diclofenac sodium, its absorption, distribution, metabolism, and excretion properties may be similar to those of diclofenac. However, comprehensive pharmacokinetic studies have not been reported. The compound is intended for research use only.
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| Toxicity/Toxicokinetics |
Toxicological data for 2,6-dichlorodiphenylamine are limited. As a research compound, comprehensive toxicological studies have not been reported. The compound is intended for research use only and is not for human therapeutic application. Standard laboratory safety precautions should be followed when handling this compound.
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| References | |
| Additional Infomation |
2,6-Dichlorodiphenylamine (2,6-Dichloro-N-phenylaniline) (CAS#: 15307-93-4) has the molecular formula C12H9Cl2N and a molecular weight of 238.11. It is a structural analog of diclofenac sodium and has anti-Candida albicans activity. Diclofenac sodium is a potent, non-selective anti-inflammatory agent and COX inhibitor. The compound is for research use only.
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| Molecular Formula |
C12H9CL2N
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|---|---|
| Molecular Weight |
238.11
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| Exact Mass |
237.011
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| CAS # |
15307-93-4
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| PubChem CID |
84867
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| Appearance |
Off-white to yellow solid powder
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| Density |
1.3±0.1 g/cm3
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| Boiling Point |
309.8±32.0 °C at 760 mmHg
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| Melting Point |
50-53 °C(lit.)
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| Flash Point |
141.2±25.1 °C
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| Vapour Pressure |
0.0±0.7 mmHg at 25°C
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| Index of Refraction |
1.650
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| LogP |
4.77
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
15
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| Complexity |
182
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| Defined Atom Stereocenter Count |
0
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| SMILES |
ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1
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| InChi Key |
HDUUZPLYVVQTKN-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C12H9Cl2N/c13-10-7-4-8-11(14)12(10)15-9-5-2-1-3-6-9/h1-8,15H
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| Chemical Name |
2,6-dichloro-N-phenylaniline
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 100 mg/mL (419.97 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (10.50 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.50 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.1997 mL | 20.9987 mL | 41.9974 mL | |
| 5 mM | 0.8399 mL | 4.1997 mL | 8.3995 mL | |
| 10 mM | 0.4200 mL | 2.0999 mL | 4.1997 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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