| Size | Price | |
|---|---|---|
| Other Sizes |
| ADME/Pharmacokinetics |
Absorption, Distribution and Excretion
Dichlorobenzyl alcohol is released almost immediately from the formulation and reaches peak concentration after 3–4 minutes. After 120 minutes, the concentration in saliva is approximately 50% of the administered dose. In preclinical studies, after transdermal administration, 90% of the administered dose of dichlorobenzyl alcohol was eliminated by the kidneys. Following metabolism, dichlorobenzyl alcohol is excreted in the urine. The pharmacokinetic properties of this drug have not been adequately studied. Metabolites/Metabolites Dichlorobenzyl alcohol is metabolized in the liver to hippuric acid. Biological Half-Life The pharmacokinetic properties of this drug have not been adequately studied. |
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| Toxicity/Toxicokinetics |
The pharmacokinetic properties of protein binding have not been fully studied.
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| References |
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| Additional Infomation |
2,4-Dichlorobenzyl alcohol is a benzyl alcohol compound whose structure involves replacing the hydrogen atoms at positions 2 and 4 with chlorine atoms. It is an antibacterial drug. It belongs to the benzyl alcohol and dichlorobenzene classes of compounds. Dichlorobenzyl alcohol is a mild, broad-spectrum antibacterial agent with antibacterial activity against bacteria and viruses that cause oral and throat infections. Health Canada has listed dichlorobenzyl alcohol as an active ingredient in many commercially available over-the-counter medications and classifies it as an anatomical therapeutic chemical. On the other hand, dichlorobenzyl alcohol is listed as an inactive ingredient in approved drugs by the U.S. Food and Drug Administration (FDA).
Drug Indications Dichlorobenzyl alcohol in combination with [DB13908] can be used over-the-counter to relieve symptoms of acute and postoperative sore throat. Mechanism of Action The use of dichlorobenzyl alcohol is related to its antibacterial, antiviral, and local anesthetic properties. The local anesthetic effect of dichlorobenzyl alcohol is thought to be due to a reduction in sodium channel blockade. Mechanism of Action The application of dichlorobenzyl alcohol is related to its antibacterial, antiviral, and local anesthetic properties. The local anesthetic effect of dichlorobenzyl alcohol is believed to be due to a reduction in sodium channel blockade. The antibacterial mechanism of dichlorobenzyl alcohol is not fully understood, but it is generally believed to be related to the denaturation of external proteins and the rearrangement of protein tertiary structures. Pharmacodynamics In vitro studies have shown that the combined use of dichlorobenzyl alcohol and pentocresol can effectively kill various viruses associated with the common cold, resulting in a reduction in viral load. Clinical trials have shown that dichlorobenzyl alcohol tablets can relieve sore throat and difficulty swallowing within 5 minutes of administration. This effect can last up to 2 hours. The relief effect reaches steady state after 45 minutes. |
| Molecular Formula |
C₇H₆CL₂O
|
|---|---|
| Molecular Weight |
177.03
|
| Exact Mass |
175.979
|
| CAS # |
1777-82-8
|
| PubChem CID |
15684
|
| Appearance |
White to off-white solid powder
|
| Density |
1.4±0.1 g/cm3
|
| Boiling Point |
268.4±25.0 °C at 760 mmHg
|
| Melting Point |
55-58 °C(lit.)
|
| Flash Point |
115.0±17.2 °C
|
| Vapour Pressure |
0.0±0.6 mmHg at 25°C
|
| Index of Refraction |
1.583
|
| LogP |
2.24
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
10
|
| Complexity |
108
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
DBHODFSFBXJZNY-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C7H6Cl2O/c8-6-2-1-5(4-10)7(9)3-6/h1-3,10H,4H2
|
| Chemical Name |
(2,4-dichlorophenyl)methanol
|
| Synonyms |
2,4Dichlorobenzyl alcohol; 2,4 Dichlorobenzyl alcohol
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~564.88 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (14.12 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (14.12 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (14.12 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.6488 mL | 28.2438 mL | 56.4876 mL | |
| 5 mM | 1.1298 mL | 5.6488 mL | 11.2975 mL | |
| 10 mM | 0.5649 mL | 2.8244 mL | 5.6488 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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