| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
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| 5mg |
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| 10mg |
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| 25mg |
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| 100mg | |||
| Other Sizes |
| Targets |
Specific molecular targets of 17-Hydroxyisolathyrol are not well characterized. As a diterpene, it may interact with cellular signaling pathways, but precise targets remain under investigation.
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|---|---|
| ln Vitro |
In vitro studies on this compound are limited. Diterpenes from Euphorbia species generally exhibit cytotoxic, anti-inflammatory, and antimicrobial activities. Specific data for 17-Hydroxyisolathyrol are scarce.
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| ln Vivo |
In vivo data are limited. Further studies are needed to evaluate the pharmacological effects and therapeutic potential of this compound.
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| Enzyme Assay |
Receptor binding or enzyme assays for this specific compound are not established. Studies on Euphorbia diterpenes typically use cell-based assays to assess biological activity.
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| Cell Assay |
Cancer cell lines or other cell types are cultured and treated with 17-Hydroxyisolathyrol. Cell viability and other parameters are measured to assess its biological activity. Published data are limited.
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| Animal Protocol |
Animal studies for this specific compound have not been reported. Further research is needed to establish in vivo efficacy.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties are not characterized. As a diterpene, it is expected to have poor oral bioavailability. Further studies are needed.
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| Toxicity/Toxicokinetics |
Specific toxicity data are not available. Euphorbia diterpenes can be toxic and irritant. Caution should be exercised when handling this compound. Comprehensive toxicological studies are lacking.
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| References | |
| Additional Infomation |
17-Hydroxyisolathyrol is a research compound with no clinical trial or regulatory approval status. Very little information is available on this compound, and it remains a subject of natural product isolation and characterization research.
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| Molecular Formula |
C20H30O5
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|---|---|
| Molecular Weight |
350.4492
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| Exact Mass |
350.209
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| CAS # |
93551-00-9
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| PubChem CID |
127256191
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
556.2±50.0 °C at 760 mmHg
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| Flash Point |
304.2±26.6 °C
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| Vapour Pressure |
0.0±3.4 mmHg at 25°C
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| Index of Refraction |
1.564
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| LogP |
1.9
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
25
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| Complexity |
634
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC1CC2(C(C1O)C(/C(=C\CC3C(C3(C)C)/C=C(\C2=O)/C)/CO)O)O
|
| InChi Key |
XKXYJTIBKZGIPR-YDYNUCMUSA-N
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| InChi Code |
InChI=1S/C20H30O5/c1-10-7-14-13(19(14,3)4)6-5-12(9-21)17(23)15-16(22)11(2)8-20(15,25)18(10)24/h5,7,11,13-17,21-23,25H,6,8-9H2,1-4H3/b10-7-,12-5-
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| Chemical Name |
(3Z,9Z)-1,11,13-trihydroxy-10-(hydroxymethyl)-3,6,6,14-tetramethyltricyclo[10.3.0.05,7]pentadeca-3,9-dien-2-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~285.35 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.13 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.13 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.13 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8535 mL | 14.2674 mL | 28.5347 mL | |
| 5 mM | 0.5707 mL | 2.8535 mL | 5.7069 mL | |
| 10 mM | 0.2853 mL | 1.4267 mL | 2.8535 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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