| Size | Price | Stock | Qty |
|---|---|---|---|
| 25g |
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| Other Sizes |
| Targets |
1-Methylpyrrolidine does not have a specific biological target. As a chemical intermediate and base, it is not typically evaluated for receptor binding or enzyme inhibition. Its primary use is in organic synthesis, where it serves as a reagent or a precursor to other compounds.
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|---|---|
| ln Vitro |
1-Methylpyrrolidine is a cyclic amine used as a building block in organic synthesis. It is a precursor to various pharmaceuticals and agrochemicals. It also acts as a base and a nucleophilic catalyst in organic reactions. Its activity is chemical, not pharmacological.
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| ln Vivo |
No in vivo activity data are documented for 1-Methylpyrrolidine in the provided sources. As a chemical intermediate, it is not evaluated for pharmacological effects in animal models. Its safety and toxicity have been assessed for industrial handling, but it is not a therapeutic agent.
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| Enzyme Assay |
In vitro assays are not typically performed for 1-Methylpyrrolidine, as it is a chemical reagent rather than a drug. Its purity and identity can be confirmed by GC, NMR, and MS. Its properties as a base and nucleophile can be assessed in chemical reactions.
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| Cell Assay |
In vitro cell-based assays are not typically performed for 1-Methylpyrrolidine. As a chemical reagent, its primary use is in organic synthesis. Its effects on cell viability or metabolism are not standard assays for this compound.
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| Animal Protocol |
In vivo animal studies are not typically conducted for 1-Methylpyrrolidine. As a chemical intermediate, its safety has been assessed for industrial handling. These studies may involve administering the compound to rodents for toxicity testing, but such details are not provided in the sources.
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| ADME/Pharmacokinetics |
1-Methylpyrrolidine has a molecular weight of 85.15 and a molecular formula of C5H11N. It is a colorless liquid with a boiling point of 80-81°C. It is miscible with water and most organic solvents. It is flammable and should be stored in a cool, well-ventilated area away from ignition sources.
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| Toxicity/Toxicokinetics |
1-Methylpyrrolidine is a corrosive and flammable liquid. It can cause severe skin burns and eye damage. It is harmful if swallowed, inhaled, or absorbed through the skin. Appropriate personal protective equipment (gloves, safety goggles, lab coat) should be worn when handling this compound. It should be used in a fume hood.
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| Additional Infomation |
Reports indicate that 1-methylpyrrolidine has been found in Arisarum vulgare and tomato (Solanum lycopersicum), and relevant data are available for reference.
1-Methylpyrrolidine is also known as N-methylpyrrolidine. It is a cyclic amine used as a building block in organic synthesis and as a precursor to pharmaceuticals and agrochemicals. It is also used as a base and a nucleophilic catalyst. It is for research use only. |
| Molecular Formula |
C5H11N
|
|---|---|
| Molecular Weight |
85.14
|
| Exact Mass |
85.089
|
| CAS # |
120-94-5
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| Related CAS # |
1-Methylpyrrolidine-d8;131857-29-9;1-Methylpyrrolidine-d3;77422-30-1
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| PubChem CID |
8454
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| Appearance |
Colorless to light yellow liquid（Density：0.819 g/cm3 ）
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| Density |
0.819
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| Boiling Point |
82.1±3.0 °C at 760 mmHg
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| Melting Point |
-90 °C
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| Flash Point |
-21.7±0.0 °C
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| Vapour Pressure |
79.6±0.1 mmHg at 25°C
|
| Index of Refraction |
1.448
|
| LogP |
0.76
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| Hydrogen Bond Donor Count |
0
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
0
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| Heavy Atom Count |
6
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| Complexity |
37.2
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
CN1CCCC1
|
| InChi Key |
AVFZOVWCLRSYKC-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C5H11N/c1-6-4-2-3-5-6/h2-5H2,1H3
|
| Chemical Name |
1-methylpyrrolidine
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~1174.40 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (29.36 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (29.36 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (29.36 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 11.7454 mL | 58.7268 mL | 117.4536 mL | |
| 5 mM | 2.3491 mL | 11.7454 mL | 23.4907 mL | |
| 10 mM | 1.1745 mL | 5.8727 mL | 11.7454 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
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