| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
|
||
| 10mg |
|
||
| 50mg |
|
||
| 100mg |
|
||
| Other Sizes |
|
1-Cyclohexyl-3-dodecyl urea (NCND; CDU; N-Cyclohexyl-N-dodecyl urea) is a novel and potent epoxide hydrolas (sEH) inhibitor with the ability to lower blood pressure in angiotensin II (Ang II) hypertension.
| ln Vivo |
1-Cyclohexyl-3-dodecylurea (CDU; N-cyclohexyl-N-dodecylurea; NCND) (ip; 3 mg/day; 4 days) decreased the Systolic blood pressure by 30 mmHg, but in animals with normotension or Ang II hypertension, maize oil vehicle had no effect on blood pressure [1].
|
|---|---|
| Animal Protocol |
Animal/Disease Models: Male SD (SD (Sprague-Dawley)) rat[1]
Doses: 3mg/day Route of Administration: intraperitoneal (ip) injection; 4-day Experimental Results: Antihypertensive properties. |
| References |
| Molecular Formula |
C₁₉H₃₈N₂O
|
|---|---|
| Molecular Weight |
310.52
|
| Exact Mass |
310.298
|
| CAS # |
402939-18-8
|
| PubChem CID |
4437430
|
| Appearance |
White to off-white solid powder
|
| LogP |
6.134
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
12
|
| Heavy Atom Count |
22
|
| Complexity |
262
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
POEWFBSYPFIYSK-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C19H38N2O/c1-2-3-4-5-6-7-8-9-10-14-17-20-19(22)21-18-15-12-11-13-16-18/h18H,2-17H2,1H3,(H2,20,21,22)
|
| Chemical Name |
1-cyclohexyl-3-dodecylurea
|
| Synonyms |
NCNDCDU1Cyclohexyl3 dodecyl urea 1 Cyclohexyl 3 dodecyl urea
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
Ethanol : ~16.67 mg/mL (~53.68 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.67 mg/mL (5.38 mM) (saturation unknown) in 10% EtOH + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear EtOH + stock solution to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2204 mL | 16.1020 mL | 32.2040 mL | |
| 5 mM | 0.6441 mL | 3.2204 mL | 6.4408 mL | |
| 10 mM | 0.3220 mL | 1.6102 mL | 3.2204 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
