| Size | Price | |
|---|---|---|
| Other Sizes |
| Targets |
1-Tetradecanol does not have a specific biological receptor target as it is primarily used as a cosmetic ingredient and chemical intermediate. The compound is used in the fabrication of temperature-regulated drug release systems based on phase-change materials. It functions as an emollient and viscous control agent in cosmetics.
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|---|---|
| ln Vitro |
In vitro biological activity of 1-tetradecanol is not typically studied as a primary endpoint, as the compound is primarily a cosmetic ingredient and chemical intermediate. It may be used in drug delivery research. Specific in vitro activity data are not available in the published literature.
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| ln Vivo |
In vivo activity of 1-tetradecanol has not been extensively studied. The compound is primarily used in cosmetic applications and as a chemical intermediate. It has been identified as a major component of essential oil. Animal model studies have not been extensively reported.
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| Enzyme Assay |
1-Tetradecanol is used as a chemical intermediate and cosmetic ingredient. Standard chemical characterization methods such as NMR spectroscopy, mass spectrometry, and chromatography are used to verify its identity and purity. No specific biological assay protocols are relevant for this compound.
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| Cell Assay |
Cell-based studies are not typically performed for 1-tetradecanol, as it is not a bioactive compound. If cytotoxicity screening is conducted, standard cell viability assays using mammalian cell lines may be employed. However, such studies are not routine for this compound.
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| Animal Protocol |
In vivo animal studies are not typically conducted for 1-tetradecanol as a therapeutic compound. The compound is used in cosmetic applications and chemical synthesis. No extensive animal model studies have been reported.
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| ADME/Pharmacokinetics |
Pharmacokinetic properties of 1-tetradecanol have been characterized to some extent. The compound is practically insoluble in water but soluble in organic solvents. It has a melting point of 38.0 to 41.0 °C. Specific PK parameters such as half-life and bioavailability have not been extensively reported.
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| Toxicity/Toxicokinetics |
Toxicological data for 1-tetradecanol are available from safety assessments. The compound is used in cosmetic applications and is considered safe at approved concentrations. It may cause skin or eye irritation in some cases. Standard toxicology studies have been conducted for cosmetic ingredient safety.
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| References | |
| Additional Infomation |
Tetradecanool is a colorless, viscous liquid (when heated) with a slightly alcoholic odor. It solidifies and floats on water. (US Coast Guard, 1999)
Tetradecano-1-ol is a long-chain fatty alcohol formed by replacing the hydroxyl group at the 1-position of tetradecane. It is a plant metabolite, a volatile oil component, and a pheromone. It is a long-chain primary fatty alcohol and also a tetradecanool. 1-Tetradecanool has been reported in Angelica sinensis, Fusarium oxysporum, and other organisms with relevant data. See also: C10-16 alcohols (note moved to); C12-16 alcohols (note moved to); C14-15 alcohols (note moved to)... See more... 1-Tetradecanol is a fatty alcohol used as an ingredient in cosmetic applications such as cold creams. It is also used as an intermediate in the chemical synthesis of other products such as sulfated alcohol. The compound is employed in the fabrication of temperature-regulated drug release systems. No clinical or therapeutic applications have been reported. |
| Molecular Formula |
C14H30O
|
|---|---|
| Molecular Weight |
214.39
|
| Exact Mass |
214.229
|
| CAS # |
112-72-1
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| Related CAS # |
1-Tetradecanol-d29;284474-78-8;1-Tetradecanol-d2;169398-02-1
|
| PubChem CID |
8209
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| Appearance |
White to off-white solid powder
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| Density |
0.8±0.1 g/cm3
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| Boiling Point |
263.2±0.0 °C at 760 mmHg
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| Melting Point |
35-39 °C(lit.)
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| Flash Point |
125.9±4.6 °C
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| Vapour Pressure |
0.0±1.2 mmHg at 25°C
|
| Index of Refraction |
1.445
|
| LogP |
6.19
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
1
|
| Rotatable Bond Count |
12
|
| Heavy Atom Count |
15
|
| Complexity |
102
|
| Defined Atom Stereocenter Count |
0
|
| InChi Key |
HLZKNKRTKFSKGZ-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C14H30O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h15H,2-14H2,1H3
|
| Chemical Name |
tetradecan-1-ol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~100 mg/mL (~466.44 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (11.66 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (11.66 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6644 mL | 23.3220 mL | 46.6440 mL | |
| 5 mM | 0.9329 mL | 4.6644 mL | 9.3288 mL | |
| 10 mM | 0.4664 mL | 2.3322 mL | 4.6644 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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