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| Other Sizes |
| Targets |
The primary target of 1-Naphthalenemethanol is bacterial pathogens. It exhibits antibacterial activity against various bacterial strains. The compound does not have a defined enzymatic or receptor target but exerts its effects through direct antimicrobial mechanisms. As a natural product extracted from Annona senegalensis, its antibacterial activity has been characterized in microbiological studies. The exact mechanism of action is not fully elucidated but is attributed to its lipophilic nature and ability to disrupt bacterial cell membranes.
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| ln Vitro |
In vitro, 1-Naphthalenemethanol demonstrates antibacterial activity against various bacterial strains. Antibacterial assays have shown that the compound effectively inhibits bacterial growth. The compound is extracted from the root bark of Annona senegalensis and has been characterized for its antimicrobial effects. The antibacterial activity is concentration-dependent and has been demonstrated in standard microbiological assays. The compound's activity is attributed to its ability to interact with bacterial cell membranes.
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| ln Vivo |
In vivo activity of 1-Naphthalenemethanol has not been extensively characterized. The compound is primarily studied for its antibacterial properties in vitro. As a natural product, it has been identified in the roots of Annona senegalensis, but detailed in vivo pharmacokinetic and pharmacodynamic studies in animal models are limited. Further in vivo studies would be needed to fully characterize its therapeutic potential and systemic effects.
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| Enzyme Assay |
In vitro enzyme/receptor binding assays for 1-Naphthalenemethanol typically involve antibacterial susceptibility testing. Bacterial strains (e.g., Staphylococcus aureus, Escherichia coli) are cultured in appropriate media and treated with serial dilutions of the compound. The minimum inhibitory concentration (MIC) is determined after 16-24 hours of incubation at 37°C using the broth microdilution method. Cell viability is assessed by measuring optical density at 600 nm or by colony counting on agar plates. The compound demonstrates concentration-dependent antibacterial activity.
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| Cell Assay |
In vitro cellular assays for 1-Naphthalenemethanol involve antibacterial activity testing against various bacterial strains. Bacterial cultures are grown in Mueller-Hinton broth and treated with serial dilutions of the compound (ranging from 0.1 to 1000 µg/mL). After 24 hours of incubation at 37°C, the optical density at 600 nm is measured to determine bacterial growth inhibition. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) are calculated from the dose-response curves. The compound shows concentration-dependent antibacterial activity.
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| Animal Protocol |
In vivo animal studies for 1-Naphthalenemethanol are limited, as the compound is primarily a natural product with antibacterial properties. For antibacterial efficacy testing, animal models of bacterial infection (e.g., murine septicemia models) could be used. Animals would be treated with the compound via oral or intraperitoneal administration at various doses, and survival rates or bacterial burden in target organs would be assessed. However, detailed in vivo protocols are not well established for this compound, and most studies have focused on in vitro characterization.
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| ADME/Pharmacokinetics |
Metabolism / Metabolites
1-Naphthylethanol is a known metabolite of 1-naphthaldehyde in the human body. The pharmacokinetic properties of 1-Naphthalenemethanol include a molecular weight of 158.20 and a molecular formula of C₁₁H₁₀O. It is soluble in DMSO at 100 mg/mL (632.11 mM). For in vivo formulations, solubility in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% saline has been demonstrated at ≥2.5 mg/mL (15.80 mM). The compound is stable as a powder at -20°C for 3 years and at 4°C for 2 years. In solvent, it is stable at -80°C for 6 months and at -20°C for 1 month. |
| Toxicity/Toxicokinetics |
The toxicity profile of 1-Naphthalenemethanol has not been extensively characterized. As a natural product extracted from plant sources, it is generally considered to have low toxicity. Standard toxicity studies would include assessment of acute oral toxicity, dermal irritation, and repeated-dose toxicity in animal models. The compound is intended for research use only and has not been approved for clinical use. Further toxicological studies would be needed to fully establish its safety profile for therapeutic applications.
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| References | |
| Additional Infomation |
(1-Naphthyl)methanol is a naphthylmethanol, whose structure is that one hydrogen atom on the methyl group in the methanol molecule is replaced by a naphth-1-yl group. It is a mouse metabolite. 1-Hydroxymethylnaphthalene is a metabolite found or produced in Escherichia coli (K12 strain, MG1655 strain). There are reports that ginger contains 1-naphthylmethanol, and relevant data are available for reference.
1-Naphthalenemethanol (CAS 4780-79-4) has a molecular formula of C₁₁H₁₀O and a molecular weight of 158.20. The compound appears as an off-white to yellow solid powder with a purity of ≥98%. It is a natural compound with antibacterial effects found in the roots of Annona senegalensis. It is a photolysis product of 1-naphthaleneacetic acid and is used in research applications. The compound is intended for research use only and is not approved for clinical use. |
| Molecular Formula |
C11H10O
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|---|---|
| Molecular Weight |
158.20
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| Exact Mass |
158.073
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| CAS # |
4780-79-4
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| PubChem CID |
20908
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| Appearance |
Off-white to yellow solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
303.6±0.0 °C at 760 mmHg
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| Melting Point |
61-63 °C(lit.)
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| Flash Point |
154.0±15.1 °C
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| Vapour Pressure |
0.0±0.6 mmHg at 25°C
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| Index of Refraction |
1.657
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| LogP |
2.27
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
12
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| Complexity |
144
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
PBLNHHSDYFYZNC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C11H10O/c12-8-10-6-3-5-9-4-1-2-7-11(9)10/h1-7,12H,8H2
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| Chemical Name |
naphthalen-1-ylmethanol
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 100 mg/mL (632.11 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (15.80 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (15.80 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (15.80 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.3211 mL | 31.6056 mL | 63.2111 mL | |
| 5 mM | 1.2642 mL | 6.3211 mL | 12.6422 mL | |
| 10 mM | 0.6321 mL | 3.1606 mL | 6.3211 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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