A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.
E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V82575 | PROTAC BRD9 Degrader-3 | 2633632-05-8 | PROTAC BRD9 Degrader-3 is a BRD9 bifunctional degrader for cancer research. | |
V82554 | PROTAC CDK9 degrader-4 | 2411021-01-5 | PROTAC CDK9 degrader-4 is a highly efficient, transcriptionally targeted CDK9 degrader. | |
V82528 | PROTAC IRAK4 ligand-3 | 2434848-46-9 | PROTAC IRAK4 ligand-3 is the ligand of PROTAC IRAK4 degrader-7 . | |
V82579 | PROTAC TTK degrader-2 | 2953426-48-5 | PROTAC TTK degrader-2 is a potent TTK (threonine tyrosine kinase) PROTAC degrader with DC50s of 3.1 and 12.4 nM in COLO-205 and HCT-116 cells, respectively. | |
V82568 | S-acetyl-PEG4-amine | 1404111-71-2 | S-acetyl-PEG4-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V82562 | SCO-PEG4-COOH | 2141976-27-2 | SCO-PEG4-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category. | |
V82577 | SCO-PEG8-COOH | 2143968-79-8 | SCO-PEG8-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category. | |
V82582 | t-Butyl acetate-PEG3-CH2COOH | 1442466-57-0 | t-Butyl acetate-PEG3-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V82551 | Thalidomide-4-NH-PEG1-COOH TFA | 2140807-20-9 | Thalidomide-4-NH-PEG1-COOH TFA is a conjugate of E3 ligase ligand and linker consisting of Thalidomide and NH-PEG3-NH-Boc. | |
V82574 | Thalidomide-4-NH-PEG1-NH2 TFA | 2490499-21-1 | Thalidomide-4-NH-PEG1-NH2 TFA is an E3 ligase (e.g. CRBN) ligand-linker conjugate consisting of Thalidomide nd NH-PEG3-NH-Boc. | |
V82576 | Thalidomide-4-NH-PEG2-COO(t-Bu) | 2140807-16-3 | Thalidomide-4-NH-PEG2-COO(t-Bu) is a t-Bu modified Thalidomide, which could be utilized as Cereblon ligand to recruit CRBN protein. | |
V76438 | Thalidomide-4-O-C10-NH2 hydrochloride | Thalidomide-4-O-C10-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76437 | Thalidomide-4-O-C11-NH2 hydrochloride | Thalidomide-4-O-C11-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76436 | Thalidomide-4-O-C12-NH2 hydrochloride | Thalidomide-4-O-C12-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V81567 | Thalidomide-4-O-C13-NH2 hydrochloride | Thalidomide-4-O-C13-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76435 | Thalidomide-4-O-C14-NH2 hydrochloride | Thalidomide-4-O-C14-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V76434 | Thalidomide-4-O-C7-NH2 hydrochloride | Thalidomide-4-O-C7-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN proteins. | ||
V81568 | Thalidomide-4-O-C9-NH2 hydrochloride | Thalidomide-4-O-C9-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein. | ||
V82549 | Thalidomide-5-methyl | 40313-92-6 | Thalidomide-5-methyl is a Thalidomide-based CRBN ligand used for CRBN protein recruitment. | |
V82522 | Thalidomide-5-NH-CH2-COO(t-Bu) | 2412056-28-9 | Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide , which could be utilized as Cereblon ligand to recruit CRBN protein. |