Ligands for E3 Ligase

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Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V82593	Fmoc-NH-PEG3-amide-CH2OCH2COOH	489427-26-1	Fmoc-NH-PEG3-amide-CH2OCH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82598	Fmoc-NH-PEG5-C2-NH2	2093277-71-3	Fmoc-NH-PEG5-C2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82540	Fmoc-Val-Phe-Boc	258879-48-0	Fmoc-Val-Phe-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and a maleimide-GGFG peptide linker.
V82559	Folate-MS432	2769735-56-8	Folate-MS432 is a PROTAC that degrades MEKs in cancer/tumor cells in a folate receptor-dependent manner.
V82541	Hexaethylene glycol dimethyl ether	1072-40-8	Hexaethylene glycol dimethyl ether is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82561	HO-PEG5-CH2COOH	52026-48-9	HO-PEG5-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V79818	HOXB7 8–25 (MDM2 32-46)		HOXB7 8–25 (MDM2 32–46) is an MDM2-derived peptide epitope that elicits antigen-specific and tumor-reactive CD4+ T cell responses.
V80546	LCL-PEG3-N3		LCL-PEG3-N3 is a decoy oligonucleotide E3 ligase ligand that may be utilized to develop chimeric molecules LCL-ER(dec) to degrade estrogen receptors.
V80547	LCL-PEG3-N3 hydrochloride		LCL-PEG3-N3 ( HCl) is a decoy oligonucleotide E3 ligase ligand that may be utilized to develop chimeric molecules LCL-ER(dec) to degrade estrogen receptors.
V3396	Lenalidomide (Revlimid, CC5013)	191732-72-6	Lenalidomide(Revlimid, CC-5013) is a derivative of thalidomide approved in the United States in 2005 for the treatment for myeloma and blood disorders called myelodysplastic syndromes.
V33447	Lenalidomide hydrochloride	1243329-97-6	Lenalidomide HCl (formerly CC-5013; CC 5013; IMiD1; trade name Revlimid),the hydrochloride salt ofLenalidomide, is a derivative of thalidomide approved for use in the United States since 2005 in the treatment for myeloma and blood disorders called myelodysplastic syndromes.
V80239	Lenalidomide sodium (lenalidomide sodium; CC-5013 sodium)		Lenalidomide (sodium) is an analogue of Thalidomide and an orally bioactive immunomodulator that acts like a molecular glue.
V40200	Lenalidomide-OH	1416990-08-3	Lenalidomide-OH, a hydroxylated analog of Lenalidomide which is a cereblon (CRBN) ligand usedfor E3 ubiquitin ligase, can be used as a E3 ligase ligand in PROTACs for the recruitment of CRBN protein.
V82587	m-PEG3-S-PEG1-C2-Boc	2365419-97-0	m-PEG3-S-PEG1-C2-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82571	m-PEG5-Propyne	1101668-41-0	m-PEG5-Propyne is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82536	Mal-amido-PEG24-acid	2171095-70-6	Mal-amido-PEG24-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82591	Mal-amido-PEG9-NHS ester	2575631-92-2	Mal-amido-PEG9-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82531	Mal-PEG2-NHS	329364-72-9	Mal-PEG2-NHS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82532	Methyl-PEG3-bromide	72593-77-2	Methyl-PEG3-bromide is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82586	Methyltetrazine-PEG4-amine hydrochloride	2656478-51-0	Methyltetrazine-PEG4-amine ( HCl) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.