PROTACs

PROTACs related products

Cat No.	Product Name	CAS No.	Product Description
V74715	(4S)-PROTAC SOS1 degrader-1	2913176-81-3	(4S)-PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader.
V83033	(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA	2417370-89-7	(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)-AHPC ligand body and may be utilized in PROTAC studies.
V58319	AD4	2918262-09-4	AD4 is an artemisinin analogue that is a proteolytic targeting chimera (PROTAC) targeting PCLAF.
V67608	ARD-2051	2632305-17-8	ARD-2051 is a potent, orally bioactive, proteolytically targeted chimeric degrader of the androgen receptor (AR).
V83031	Boc-NH-PEG7-acetic acid	141282-29-3	Boc-NH-PEG7-acetic acid is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V3439	BSJ-03-123	2361493-16-3	BSJ-03-123 is a novel, potentcyclin-dependent kinase 6 (CDK6)-selective small-molecule degrader (PROTAC: proteolysis targeting chimera).
V130726	BT-O2C	3055107-34-8	BT-O2C is a highly selective p300 PROTAC degrader.
V83030	Cbz-PEG2-bromide	2100283-00-7	Cbz-PEG2-bromide is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V77160	CCT367766 formic		CCT367766 formic is a potent orally bioactive protein, a third-generation heterofunctional and Cereblon ligand-based pirin-targeted protein degradation probe (PDP, or PROTAC) that can reduce pirin protein expression at low concentrations.
V83041	Dovitinib-RIBOTAC	2759351-68-1	Dovitinib RIBOTAC is a targeted RNA degrader that cleaves precursor-miR-21 with great potency and selectivity.
V3586	Gefitinib-based PROTAC 3	2230821-27-7	Gefitinib-based PROTAC 3 is a novel, potent and selective VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R).
V2185	GMB-475	2490599-18-1	:GMB-475 is a novel and potent degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance.
V75491	GNE-987	2417371-71-0	GNE-987 is a PROTAC linked to a von Hippel-Lindau ligand and a BRD4 ligand.
V60079	GSK215	2743427-26-9	GSK215 is a potent and selective PROTAC adhesion kinase (FAK) degrader, pDC50 The value is 8.4.
V83049	Legumain inhibitor 1	2361157-34-6	Legumain inhibitor 1 is a potent and specific Legumain inhibitor (antagonist) with IC50 of 3.6 nM.
V80843	MS9715		MS9715 is a potent and specific NSD3 PROTAC.
V70220	MS98	2376137-31-2	MS98 is an effective and selective PROTAC AKT degrader.
V74168	NJH-2-056	2858812-69-6	NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) connecting the OTUB1 recruitment factor EN523 and the CFTR chaperone lumacaftor.
V142740	PIN1 ligand-2	2957895-02-0	PIN1 ligand-2 is a PROTAC target protein ligand.
V93845	PROTAC ALK degrader-3		PROTAC ALK degrader-3 (4B) is an orally active PROTACs-based ALK degrader that effectively induces sustained degradation of ALK fusion protein and strong inhibition of downstream pathways in Karpas 299 cells with an IC50 of 119.33 nM.