PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.
A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V77919 | Amino-PEG2-CH2CH2-SH hydrochloride | Amino-PEG2-CH2CH2-SH (HCl) is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | ||
V8373 | Amino-PEG2-t-butyl ester | 756525-95-8 | Amino-PEG2-t-butyl ester is a PEG analogue containing an amino group with a t-butyl protected carboxyl group. | |
V82850 | Amino-PEG24-acid | 2563873-76-5 | Amino-PEG24-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V11104 | Amino-PEG3-acid | 784105-33-5 | Amino-PEG3-acid is a PEG analogue containing an amino group with a terminal carboxylic acid. | |
V5760 | Amino-PEG3-alcohol | 6338-55-2 | Amino-PEG3-alcohol is a PEG analogue containing an amino group with a hydroxyl group. | |
V11108 | Amino-PEG3-t-butyl ester | 252881-74-6 | Amino-PEG3-t-butyl ester is a PEG analogue containing an amino group with a t-butyl protected carboxyl group. | |
V11109 | Amino-PEG4-acid | 663921-15-1 | Amino-PEG4-acid is a PEG analogue containing an amino group with a terminal carboxylic acid. | |
V11110 | Amino-PEG4-alcohol | 86770-74-3 | Amino-PEG4-alcohol is a PEG analogue containing an amino group with a hydroxyl group. | |
V77922 | Amino-PEG4-C2-SH hydrochloride | Amino-PEG4-C2-SH HCl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | ||
V5620 | Amino-PEG4-t-butyl ester | 581065-95-4 | Amino-PEG4-t-butyl ester is a PEG analogue containing an amino group with a t-butyl protected carboxyl group. | |
V8602 | Amino-PEG5-alcohol | 34188-11-9 | Amino-PEG5-alcohol is a PEG analogue containing an amino group with a hydroxyl group. | |
V7830 | Amino-PEG6-alcohol | 39160-70-8 | Amino-PEG6-alcohol is a PEG analogue containing an amino group with a hydroxyl group. | |
V77923 | Amino-PEG7-C2-SH hydrochloride | Amino-PEG7-C2-SH HCl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | ||
V82771 | Aminooxy-PEG8-acid | 2055269-60-6 | Aminooxy-PEG8-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V77231 | ATP-PEG8-Biotin | ATP-PEG8-Biotin is a PEG-like linker that binds ATP. | ||
V82774 | AZD9496 deacrylic acid phenol | 2173404-70-9 | AZD9496 deacrylic acid phenol is a fragment of the PROTAC ER Degrader-4 target protein ligand. | |
V82885 | Azide-PEG3-Desthiobiotin | 1426828-06-9 | Azide-PEG3-Desthiobiotin is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
V80255 | Azido-C1-PEG4-C3-NH2 | Azido-C1-PEG4-C3-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | ||
V82919 | Azido-PEG1 | 1517-05-1 | Azido-PEG1 is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
V82742 | Azido-PEG10-azide | 1421783-42-7 | Azido-PEG10-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. |