Ligands for Target Protein for PROTAC

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Ligands for Target Protein for PROTAC

Target proteins are often proteins that may contribute significantly to the development of illnesses through overexpression or accumulation. Numerous PROTACs have been created to destroy kinases (like MEK, KRAS, CDK, and Bcr/Abl), transcription factors (like p53, STAT, RAR, ER, and AR), epigenetic tools (like HDAC and BET bromodomain), and E3 ligases themselves (like MDM2).

Target proteins are often proteins that may contribute significantly to the progression of illnesses through overexpression or accumulation. Numerous PROTACs have been created to destroy E3 ligases including MDM2, MEK, KRAS, CDK, and Bcr/Abl, transcription factors like p53, STAT, RAR, ER, and AR, epigenetic tools like HDAC, and BET bromodomain.

Ligands for Target Protein for PROTAC related products

Cat No.	Product Name	CAS No.	Product Description
V82600	Nonylbenzene-PEG5-OH	20636-48-0	Nonylbenzene-PEG5-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V51750	OICR-9429-N-C2-NH2	2407457-55-8	OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) and may be utilized to prepare PROTAC.
V74086	PD0325901-O-C2-dioxolane	2581116-22-3	PD0325901-O-C2-dioxolane contains the major component of the MEK inhibitor PD0325901.
V76602	PROTAC Bcl-xL ligand-1		PROTAC Bcl-xL ligand-1 is the ligand of Bcl-xL and may be utilized in the preparation /synthesis of PROTAC.
V76597	PROTAC BRD4 ligand-2 hydrochloride		PROTAC BRD4 ligand-2 HCl is a ligand for the target protein BRD4 and may be used in the synthesis/preparation of PROTAC CFT-2718.
V76595	PROTAC CDK9 ligand-1		PROTAC CDK9 ligand-1 is a CDK9 ligand that may be utilized in the preparation /synthesis of PROTAC.
V69152	SI-109	2429877-30-3	SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with anti-tumor activity.
V76501	SMD-3040 TFA		SMD-3040 TFA is a selective SMARCA2 degrader.
V82602	t-Boc-Aminooxy-PEG4-amine	2496687-02-4	t-Boc-Aminooxy-PEG4-amine is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82616	Thalidomide-5-propargyne-NH2 hydrochloride	2490402-62-3	Thalidomide-5-propargyne-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82615	Thalidomide-O-amido-PEG4-propargyl	2496687-00-2	Thalidomide-O-amido-PEG4-propargyl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82607	THP-PEG10-THP	42749-29-1	THP-PEG10-THP is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the PEG category, may be utilized to prepare PROTAC protein degraders.