Size | Price | Stock | Qty |
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1mg |
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5mg |
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Other Sizes |
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Targets |
LPA1 Receptor 2.7 nM (IC50)
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ln Vitro |
The LPA1-B103 and Vector-B103 cells exhibit 0.1~10000 μM of VT107, which inhibits Ca2+ mobilization[1]. ONO-9780307 interacts to an orthosteric location in LPA1 and is employed to solve the crystal structure of that protein[1].
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References |
[1]. Mizuno H, et al. Lysophospholipid G protein-coupled receptor binding parameters as determined by backscattering interferometry. J Lipid Res. 2019;60(1):212-217.
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Molecular Formula |
C30H35NO7
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Molecular Weight |
521.60
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CAS # |
856691-44-6
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SMILES |
COC1=C(C)C(OC)=CC([C@H]([C@@](CN2C=C(C(OC)=O)C(=C2)CC(O)=O)([H])CC2CC3C(=CC=CC=3)C2)C)=C1
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: 100 mg/mL (191.72 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 5 mg/mL (9.59 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.9172 mL | 9.5859 mL | 19.1718 mL | |
5 mM | 0.3834 mL | 1.9172 mL | 3.8344 mL | |
10 mM | 0.1917 mL | 0.9586 mL | 1.9172 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.