|
V2967
|
PF-05089771 |
1235403-62-9 |
PF-05089771 (PF05089771) is a potent and subtype selective NaV1.7 inhibitor (IC50 = 11 nM) and Nav1.8voltage-gated sodium channelblocker with the potential to be used in the treatment of chronic neuropathic pain. |
|
V0522
|
Semaxanib (SU-5416) |
204005-46-9 |
Semaxanib (also known as SU5416) is a novel, potent and selective VEGFR (Flk-1/KDR) inhibitor with potential anticancer activity. |
|
V0729
|
Ritonavir (ABT-538; Norvir) |
155213-67-5 |
Ritonavir (previously known as ABT-538; A-84538; RTV; ABT538, trade name: Norvir) is a L-valine derivative and potent inhibitor of HIV-1 protease used to treat HIV infection and AIDS. It is widely used as a booster for other protease inhibitors/PIs such as lopinavir, and makes them work better. |
|
V0024
|
Belnacasan (VX765) |
273404-37-8 |
Belnacasan (also known as VX-765) is a novel, potent, selective and orally bioactive prodrug of VRT-043198 which is a potent and selective inhibitor of caspase-1 withKi values of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. |
|
V0411
|
(+)-JQ1 |
1268524-70-4 |
(+)-JQ1 is a novel, potent and highly specific BET (Bromodomain and extra terminal domain) bromodomain inhibitor with antineoplastic activity. |
|
V0390
|
EPZ015666 (GSK3235025) |
1616391-65-1 |
EPZ015666 (GSK-3235025), an analog ofEPZ-015866, is a potent, selective and orally bioavailable inhibitor of PRMT5 (protein arginine methyltransferase) with antineoplastic activity. |
|
V0572
|
Imatinib Mesylate (STI571; Gleevec; Glivec) |
220127-57-1 |
Imatinib Mesylate (also known as STI571 mesylate; trade names: Gleevec or Glivec), the mesylate salt of imatinib, is an orally bioavailable,potent,multi-kinase inhibitor of v-Abl, c-Kit and PDGFR with potential antitumor activity. |
|
V0035
|
Pomalidomide (CC4047 or actimid) |
19171-19-8 |
Pomalidomide (formerly also known as CC-4047 or actimid), an analog of thalidomide, is a potent andorally bioavailable immunomodulatory molecule with antineoplastic activity. |
|
V0415
|
Apabetalone (RVX-08, RVX-000222) |
1044870-39-4 |
Apabetalone (also known as RVX-208, RVX000222) is a novel and potent inhibitor of BET (Bromodomain and Extra-Terminal) bromodomain (BD) with potential anti-inflammatory activity and the potential to be used in the treatment of cardiovascular diseases. |
|
V0503
|
Apatinib (Rivoceranib, YN968D1) |
811803-05-1 |
Apatinib (formerly known as Rivoceranib,YN-968D1) is a potent, orally bioavailable, and selective inhibitor of the VEGF (vascular endothelial growth factor receptor) signaling pathway withpotential antiangiogenic and antineoplastic activities. |
|
V0174
|
Rapamycin (Sirolimus; AY22989) |
53123-88-9 |
Rapamycin (also known as Sirolimus; AY-22989), a natural macrocyclic lactone isolated from the bacterium Streptomyces hygroscopicus, is a specific and potent mTOR inhibitor with IC50 of ~0.1 nM in HEK293 cells. |