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Purity: ≥98%
Famciclovir (also known as BRL 42810) is a guanine class of antiviral drug used for the treatment of various herpesvirus infections, such as herpes zoster (shingles). It is also indicated for treatment of recurrent episodes of herpes simplex in HIV patients. It is a prodrug form of penciclovir with improved oral bioavailability.
| ln Vitro |
By deacetylation, famciclovir metabolizes into BRL 42359, which oxidizes to penciclovir[3].
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|---|---|
| ln Vivo |
Necrotic hepatitis mice can be effectively cured by famciclovir (50–400 mg/kg; p.o. three times per day for a total of 10 doses)[1].
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| Animal Protocol |
Animal Model: Four- to five-week-old Balb/c mice with HSV-1 infection[1]
Dosage: 50, 100, 200 and 400 mg/kg Administration: Oral gavage; 50-400 mg/kg per day divided into three doses given every 8 h; for total 10 doses Result: significantly decreased the daily incidence of hepatitis when administered at a dose of 50 mg/kg; however, the treatment group receiving doses of 50 and 100 mg/kg was unable to isolate the infectious virus. |
| References |
| Molecular Formula |
C14H19N5O4
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|---|---|
| Molecular Weight |
321.33176
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| Exact Mass |
321.14
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| Elemental Analysis |
C, 52.33; H, 5.96; N, 21.79; O, 19.92
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| CAS # |
104227-87-4
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| Related CAS # |
Famciclovir-d4;1020719-42-9
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| Appearance |
Solid powder
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| SMILES |
CC(OCC(COC(C)=O)CCN1C=NC2=CN=C(N)N=C12)=O
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| InChi Key |
GGXKWVWZWMLJEH-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
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| Chemical Name |
[2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate
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| Synonyms |
Famvir, BRL-42810; BRL42810; BRL 42810
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : 64~100 mg/mL ( 199.16~311.21 mM )
Water : 64 mg/mL Ethanol : ~48 mg/mL |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.78 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.78 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.78 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 120 mg/mL (373.45 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1121 mL | 15.5603 mL | 31.1207 mL | |
| 5 mM | 0.6224 mL | 3.1121 mL | 6.2241 mL | |
| 10 mM | 0.3112 mL | 1.5560 mL | 3.1121 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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