| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| Other Sizes |
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| ln Vitro |
5-Ethynyl-2'-deoxyuridine (EdU) staining is a quick, accurate, and repeatable technique for examining the proliferation of cells in the central nervous system [1].
|
|---|---|
| ln Vivo |
Two-month-old female mice's dentate gyrus showed a little increase in the amount of 5-Ethynyl-2'-deoxyuridine (EdU; one intraperitoneal injection of EdU at 10, 20, 50, 100, or 200 mg/kg)-positive cells [1].
|
| Animal Protocol |
Animal/Disease Models: Two month old female mice[1]
Doses: 10, 20, 50, 100 or 200 mg/kg Route of Administration: Single injection; intraperitoneally; 4 hrs (hours) after EdU injection, brains were processed for EdU staining. Experimental Results: EdU positive cell Numbers slightly increased in a dose-dependent manner both in control and running mice. |
| References |
|
| Molecular Formula |
C11H12N2O5
|
|---|---|
| Molecular Weight |
252.22338
|
| Exact Mass |
252.075
|
| CAS # |
61135-33-9
|
| PubChem CID |
472172
|
| Appearance |
White to yellow solid powder
|
| Density |
1.55g/cm3
|
| Melting Point |
199 °C
|
| Index of Refraction |
1.644
|
| LogP |
-1.3
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
18
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| Complexity |
463
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| Defined Atom Stereocenter Count |
3
|
| SMILES |
C#CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O
|
| InChi Key |
CDEURGJCGCHYFH-DJLDLDEBSA-N
|
| InChi Code |
InChI=1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h1,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s1
|
| Chemical Name |
5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~198.24 mM)
H2O : ~25 mg/mL (~99.12 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 4 mg/mL (15.86 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9648 mL | 19.8240 mL | 39.6479 mL | |
| 5 mM | 0.7930 mL | 3.9648 mL | 7.9296 mL | |
| 10 mM | 0.3965 mL | 1.9824 mL | 3.9648 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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