| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
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Purity: ≥98%
ɑ-Tocopherolquinone (Vitamin E Quinone), a vitamin E oxidation product with antioxidant activities, was an investigational drug in phase II clinical trials for the treatment of inherited mitochondrial respiratory chain diseases, however this research has been discontinued. It has also been used for the treatment of Frederich's ataxia and MEILAS syndrome.
| References |
: Generation of superoxide and singlet oxygen from a-tocopherolquinone and analogues ANA G CRISOSTOMO, RAPHAEL B MORENO, SUPPIAH NAVARATNAM, JAMES A WILKINSON, ROGER H BISBY Free Radic Res. Author manuscript; available in PMC 2007 Nov 19.Published in final edited form as: Free Radic Res. 2007 Jun; 41(6): 730–737. doi: 10.1080/10715760701324075 PMCID: PMC2080821
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| Molecular Formula |
C29H50O3
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|---|---|
| Molecular Weight |
446.7055
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| Exact Mass |
446.376
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| CAS # |
7559-04-8
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| PubChem CID |
2734086
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| Appearance |
Light yellow to yellow liquid
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| Density |
0.9±0.1 g/cm3
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| Boiling Point |
535.8±29.0 °C at 760 mmHg
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| Flash Point |
291.9±20.8 °C
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| Vapour Pressure |
0.0±3.2 mmHg at 25°C
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| Index of Refraction |
1.486
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| LogP |
10.42
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
15
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| Heavy Atom Count |
32
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| Complexity |
697
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| Defined Atom Stereocenter Count |
3
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| SMILES |
O([H])[C@@](C([H])([H])[H])(C([H])([H])C([H])([H])C1C(C(C([H])([H])[H])=C(C([H])([H])[H])C(C=1C([H])([H])[H])=O)=O)C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
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| InChi Key |
LTVDFSLWFKLJDQ-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C29H50O3/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8,32)19-17-26-25(7)27(30)23(5)24(6)28(26)31/h20-22,32H,9-19H2,1-8H3
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| Chemical Name |
ɑ-2-(3-Hydroxy-3,7,11,15-tetramethylhexadecyl)-3,5,6-trimethyl-p-benzoquinone
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| Synonyms |
EPIA 000 A 0001 EPI A 0001 EPIA 0001A-0001 EPI-A-0001 EPIA-0001 A 0001 EPI A 0001 Vitamin E Quinone (D-form) D-α-Tocopherylquinone,
Tocopherylquinone
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~111.93 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.60 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (5.60 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.60 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2386 mL | 11.1929 mL | 22.3859 mL | |
| 5 mM | 0.4477 mL | 2.2386 mL | 4.4772 mL | |
| 10 mM | 0.2239 mL | 1.1193 mL | 2.2386 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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