Size | Price | Stock | Qty |
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1mg |
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5mg |
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10mg |
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Other Sizes |
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Targets |
NK1 receptor[1]
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ln Vitro |
[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, icv) are equally effective in raising heart rate (HR) and mean arterial blood pressure (MAP), although their time courses are different. Face washing and sniffing are increased dose-dependently by both agonists, but only [Sar9,Met(O2)11]-Substance P causes grooming[1].
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References |
[1]. Cellier E, et al. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28.
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Molecular Formula |
C66H101F3N18O17S
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Molecular Weight |
1507.68
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CAS # |
2828433-10-7
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Related CAS # |
[Sar9,Met(O2)11]-Substance P;110880-55-2
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SMILES |
C(F)(F)(F)C(=O)O.C(N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N)CCS(=O)(=O)C)CC1C=CC=CC=1)CC1C=CC=CC=1)(=O)[C@H](CCCCN)NC([C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(N)=N)=O
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O: 100 mg/mL (66.33 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (33.16 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 0.6633 mL | 3.3164 mL | 6.6327 mL | |
5 mM | 0.1327 mL | 0.6633 mL | 1.3265 mL | |
10 mM | 0.0663 mL | 0.3316 mL | 0.6633 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.