Size | Price | Stock | Qty |
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50mg |
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100mg |
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250mg |
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500mg |
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Other Sizes |
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Gamma-glutamylcysteine (amma-Glu-Cys) is a substrate for biosynthesis of L-glutathione by glutathione synthetase. It is a dipeptide acting as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). It can also increase anti-inflammatory cytokines such as IL-10 and reduce pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β).
ln Vitro |
The antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) were activated when 200 μM gamma-glutamylcysteine was co-treated with Aβ40 oligomers. This also led to a considerable rise in total antioxidant levels (TAC) and GSH, as well as a decrease in the GSSG/GSH ratio. Additionally, gamma-glutamylcysteine reduces the levels of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), increases the anti-inflammatory cytokine IL-10, and attenuates alterations in metalloproteinase activity in astrocytes treated with oligomeric Aβ40[1].
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References |
[1]. Braidy N, et al. The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes. Front Aging Neurosci. 2019 Aug 8;11:177.
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Molecular Formula |
C8H14N2O5S
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Molecular Weight |
250.2722
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CAS # |
636-58-8
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SMILES |
S([H])C([H])([H])[C@@]([H])(C(=O)O[H])N([H])C(C([H])([H])C([H])([H])[C@@]([H])(C(=O)O[H])N([H])[H])=O
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ~100 mg/mL (~399.57 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (399.57 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.9957 mL | 19.9784 mL | 39.9568 mL | |
5 mM | 0.7991 mL | 3.9957 mL | 7.9914 mL | |
10 mM | 0.3996 mL | 1.9978 mL | 3.9957 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.