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Purity: ≥98%
Curcumol is a selective, potent, naturally occuring and pure monomer isolated from Rhizoma Curcumaeis with potential antitumor activities. It shows potent in vitro antiproliferative activity and high in vivo antitumor efficacy.vAs an inducer of apoptosis, curcumol induced cell death in human lung adenocarcinoma (ASTC-a-1) cells by inducing G(2)/M phase arrest, nuclear fragmentation, phosphatidylserine externalization and a rapid translocation of Bax from cytosol into mitochondria. Curcumol also benefits rheumatoid arthritis treatment through suppressing the fibroblast-like synoviocytes (FLS) proliferation and DNA synthesis.
| ln Vitro |
The principal substance isolated from turmeric root is called curcumin ((-)-Curcumol). By downregulating CDKL3, curcumin inhibits the growth of cholangiocarcinoma cells [2]. Curcumin uses reactive oxygen species and the Akt/GSK3β/cyclin D1 pathway to cause cell cycle arrest in colon cancer cells [3]. Through JNK1/2 and Akt-dependent NF-κB signaling pathways, curcumin inhibits MMP-9 and hence prevents breast cancer cells from metastasizing [4].
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| ln Vivo |
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| References |
[1]. Wei W, et al. Curcumol: From Plant Roots to Cancer Roots. Int J Biol Sci. 2019;15(8):1600-1609. Published 2019 Jun 4.
[2]. Zhang J, et al. Curcumol Exerts Anticancer Effect in Cholangiocarcinoma Cells via Down-Regulating CDKL3. Front Physiol. 2018;9:234. Published 2018 Mar 20. [3]. Wang J, et al. Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway. J Ethnopharmacol. 2018;210:1-9. [4]. Ning L, et al. Curcumol Suppresses Breast Cancer Cell Metastasis by Inhibiting MMP-9 Via JNK1/2 and Akt-Dependent NF-κB Signaling Pathways. Integr Cancer Ther. 2016;15(2):216-225. |
| Molecular Formula |
C15H24O2
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| Molecular Weight |
236.35
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| CAS # |
4871-97-0
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| Related CAS # |
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| SMILES |
O1[C@@]2(C([H])([H])C(=C([H])[H])[C@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])[C@]13C([H])([H])[C@@]2([H])C([H])(C([H])([H])[H])C([H])([H])[H])O[H]
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| InChi Key |
QRMPRVXWPCLVNI-YYFQZIEXSA-N
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| InChi Code |
InChI=1S/C15H24O2/c1-9(2)13-8-14-11(4)5-6-12(14)10(3)7-15(13,16)17-14/h9,11-13,16H,3,5-8H2,1-2,4H3/t11-,12-,13-,14-,15+/m0/s1
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| Chemical Name |
(3S,3aS,5S,6R,8aS)-Octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (10.58 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2310 mL | 21.1551 mL | 42.3101 mL | |
| 5 mM | 0.8462 mL | 4.2310 mL | 8.4620 mL | |
| 10 mM | 0.4231 mL | 2.1155 mL | 4.2310 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT00475683 | Completed | Other: Mouth wash Dietary Supplement: Curcumol |
Chemotherapy Induced Mucositis | Hadassah Medical Organization | January 2009 | Phase 3 |
Curcumol inhibited p-Jak2 protein expression of FLS, and the STAT1 and STAT3 protein expression in FLS from patients with RA was not inhibited by curcumol.Evid Based Complement Alternat Med.2012;2012:746426. |
Inhibitory effect of different concentration curcumol on FLS proliferation in patients with RA.Evid Based Complement Alternat Med.2012;2012:746426. |
Curcumol inhibited STAT1 DNA-binding activity in FLS from patients with RA.Evid Based Complement Alternat Med.2012;2012:746426. |
Inhibitory effect of different concentration curcumol on FLS DNA synthesis in patients with RA. |
Curcumol inhibited STAT3 DNA-binding activity in FLS from patients with RA. |
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