Among the thiazide diuretics is chlorthalidone. Peak serum concentrations are attained 2–6 hours after oral dosing. Chlorthalidone has a half-life of roughly 42 (range 29–55) hours, which can increase to 45–60 hours after repeated administration. The half-life of chlorthalidone, however, differs greatly amongst people. The kidneys eliminate chlorthalidone unaltered. Chlorthalidone's natriuretic impact peaks at 18 hours and lasts for more than 48 hours. When chlorthalidone dosages were compared, it was found that 25 mg per day was nearly as efficacious as higher doses while carrying a lower risk of hypokalemia [1]. Magnesium hydroxide did not prevent the recurrence of calcium oxalate stones, whereas chlorthalidone did. Analyze if magnesium hydroxide or chlorthalidone is more successful at preventing the recurrence of kidney stones caused by calcium oxalate. There was a double-blind randomized assignment design, and the daily dose was either 25 or 50 mg. 1,300 or 650 mg of chlorthalidone. One of the two options: magnesium hydroxide or a similar placebo. All groups experienced a significant decrease in stone incidents when compared to pre-treatment levels. Throughout the experiment, the groups receiving low- and high-dose magnesium hydroxide demonstrated a reduction in stones of 73.9% and 62.3%, respectively (p less than 0.001 and less than 0.01), while the placebo group had 56.1% fewer stones than expected (p less than 0.01). 0.01). Treatment with chlorthalidone reduced expected rates by 90.1%, and the effects of both dosages were comparable. Chlorthalidone outperformed magnesium hydroxide or placebo when comparing treatments (p less than 0.01). The significant decreases in stone events observed in cases of placebo or inactive treatment highlight the favorable treatment bias that arises from using historical controls, and also highlight the necessity of using suitable experimental design [2].

[1]. Barrios V, et al. Which thiazide to choose as add-on therapy for hypertension? Integr Blood Press Control. 2014 Jul 30;7:35-47.
[2]. Ettinger B, et al. Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol. 1988 Apr;139(4):679-84.

C14H11CLN2O4S

338.76

77-36-1

Chlorthalidone-d4;1794941-44-8

C1=CC=C2C(=C1)C(=O)NC2(C3=CC(=C(C=C3)Cl)S(=O)(=O)N)O

JIVPVXMEBJLZRO-UHFFFAOYSA-N

InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)

2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide

Thalitone Chlorthalidone Chlorphthalidolone Phthalamodine OxodolineChlortalidone Phthalamudine Hygroton Phthalamudine

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

DMSO : ≥ 41 mg/mL (~121.03 mM)

Solubility in Formulation 1: ≥ 2.08 mg/mL (6.14 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.

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Solubility in Formulation 2: ≥ 2.08 mg/mL (6.14 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.

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 (Please use freshly prepared in vivo formulations for optimal results.)