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Purity: ≥98%
ADT-OH is a analogue of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. ADT-OH significantly reduced tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells in the in vitro glucose-oxygen deprivation (OGD) model. Last but not least, ADT-OH enhanced functional outcomes in mice given MCAO and tPA infusion. H2S donors may have prevented the Akt-VEGF-MMP9 cascade from increasing tPA-induced cerebral hemorrhage. Giving out H2S donors could be a novel way to increase the safety of tPA after a stroke.
| Molecular Formula |
C9H6OS3
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|---|---|
| Molecular Weight |
226.326
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| Exact Mass |
225.9581
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| Elemental Analysis |
C, 47.76; H, 2.67; O, 7.07; S, 42.50
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| CAS # |
18274-81-2
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| Related CAS # |
18274-81-2
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| Appearance |
Yellow solid powder
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| SMILES |
C1=CC(=CC=C1C2=CC(=S)SS2)O
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| InChi Key |
IWBBKLMHAILHAR-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C9H6OS3/c10-7-3-1-6(2-4-7)8-5-9(11)13-12-8/h1-5,10H
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| Chemical Name |
5-(4-hydroxyphenyl)dithiole-3-thione
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| Synonyms |
Desmethylanethol trithione ACS1; ADT-OH
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 45~125 mg/mL (198.8~552.3 mM)
Ethanol: ~12 mg/mL (~53.0 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (9.19 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (9.19 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.4183 mL | 22.0916 mL | 44.1833 mL | |
| 5 mM | 0.8837 mL | 4.4183 mL | 8.8367 mL | |
| 10 mM | 0.4418 mL | 2.2092 mL | 4.4183 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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