| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| Other Sizes |
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| ln Vitro |
It was discovered that acrylavine is a powerful MCT4 dye that inhibits the binding of basigin to MCT4. Numerous astroblastoma neurosphere cell lines exhibit considerable growth and self-renewal inhibition when exposed to acrylamide [1]. Acriflavine, which inhibits the matrix and CML cell proliferation, is equivalent to HIF-1. It may reduce CML cells' capacity to produce stem cells [2].
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|---|---|
| ln Vivo |
Acriflavine has the ability to prevent VEGF expression and the development of blood vessels in tumors [1]. Acriflavine inhibited the growth of animal models and the upkeep of LSCs in mouse tumor CML models [2]. In mouse tumor models, acriflavine slows the growth of tumors. When sunitinib and arciflavine are taken together, there is a considerable reduction in the expression of TGF-β and vascular endothelial growth factor, as well as a reduction in tumor blood vessels. This leads to an increase in tumor medial wall and cell inflammation [3].
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| References |
[1]. Voss DM, et al. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017 Jun 27;7(1):4292.
[2]. Cheloni G, et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood. 2017 Jun 2. pii: blood-2016-10-745588. [3]. Yin T, et al. HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model. Oncol Res. 2014;22(3):139-45 |
| Molecular Formula |
C14H14N3.CL.C13H11N3
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|---|---|
| Molecular Weight |
468.9895
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| CAS # |
8048-52-0
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| Related CAS # |
Acriflavine hydrochloride;69235-50-3
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| SMILES |
NC(C=C1)=CC(C1=C2)=NC3=C2C=CC(N)=C3.NC(C=C4)=CC(C4=C5)=[N+](C)C6=C5C=CC(N)=C6.[Cl-]
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ≥ 25 mg/mL (~96.25 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2 mg/mL (7.70 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1322 mL | 10.6612 mL | 21.3224 mL | |
| 5 mM | 0.4264 mL | 2.1322 mL | 4.2645 mL | |
| 10 mM | 0.2132 mL | 1.0661 mL | 2.1322 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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