| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
With IC50 values of 100–200 nM, CT52923 inhibits PDGFRs and stem cell factor receptors[1]. According to an experiment for cell migration, CT52923 (0.01-30 μM; 24 h) inhibits the migration of smooth muscle cells or fibroblast ischemia caused by growth factor stimulation [1].
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|---|---|
| ln Vivo |
CT52923 (cervical; 5, 15, 30 and 50 mg/kg; twice daily) significantly inhibits intimal neogenesis after carotid artery injury [1].
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| Cell Assay |
Cell Migration Assay [1]
Cell Types: Rat A10 smooth muscle cells Tested Concentrations: 0.01-30 μM Incubation Duration: 24 h Experimental Results: Inhibits cell migration induced by PDGF, IC50 is 64 nM. 64 and 280 nM[1]. |
| Animal Protocol |
Animal/Disease Models: Rat carotid balloon angioplasty model [1].
Doses: 5, 15, 30 and 50 mg/kg Route of Administration: po (oral gavage); twice (two times) daily Experimental Results: Inhibition of PDGF-mediated vascular injury response. |
| References |
[1]. J C Yu, et al. Efficacy of the novel selective platelet-derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following vascular injury. J Pharmacol Exp Ther. 2001 Sep;298(3):1172-8.
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| Molecular Formula |
C23H25N5O4S
|
|---|---|
| Molecular Weight |
467.544
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| Exact Mass |
467.16
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| Elemental Analysis |
C, 59.09; H, 5.39; N, 14.98; O, 13.69; S, 6.86
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| CAS # |
205256-55-9
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| SMILES |
S=C(N1CCN(CC1)C2=C3C=C(OC)C(OC)=CC3=NC=N2)NCC4=CC=C5OCOC5=C4
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| InChi Key |
ORRFUYVNMZSYIC-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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| Chemical Name |
N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carbothioamide
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| Synonyms |
CT52923; CT-52923; CT 52923; KN734; KN-734; KN 734;
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~106.94 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.35 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1389 mL | 10.6943 mL | 21.3885 mL | |
| 5 mM | 0.4278 mL | 2.1389 mL | 4.2777 mL | |
| 10 mM | 0.2139 mL | 1.0694 mL | 2.1389 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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