Size | Price | Stock | Qty |
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100mg |
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250mg |
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500mg |
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1g |
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Other Sizes |
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ln Vitro |
6-Aminochrysene inhibits the hydroxylation of aniline, the O-demethylation of p-nitroanisole, and the N-demethylation of aminopyrine in rat liver microsomes. Pretreatment of rats with 6-amino groups in vitro greatly reduced N-demethylation, but dramatically increased hydroxylation and O-demethylation [1].
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ln Vivo |
6-Aminochrysene has a tumor suppressor effect on human breast cancer and inhibits the growth of a variety of solid experimental tumors in vivo [1]. When mice were given 6-amino topically over an extended period of time, they developed benign skin tumors after three months and malignant skin tumors after seven months. Compared to male mice, female mice replied first. When 6-amino was given ventrally as opposed to dorsally, skin cancers were generated more quickly. Following cutaneous application, urinary excretion is around twice as high as following oral treatment [2].
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References |
[1]. Russo R, et al. Effects of 6-aminochrysene on liver microsomal enzyme activity. Xenobiotica. 1976 Apr;6(4):201-5.
[2]. Lambelin G, et al. Carcinogenicity of 6-aminochrysene in mice. Eur J Cancer. 1975 May;11(5):327-34 |
Molecular Formula |
C18H13N
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Molecular Weight |
243.30300
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CAS # |
2642-98-0
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Appearance |
Typically exists as solids (or liquids in special cases) at room temperature
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SMILES |
NC1=C2C=CC=CC2=C3C(C4=CC=CC=C4C=C3)=C1
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL (~411.02 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (8.55 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 4.1102 mL | 20.5508 mL | 41.1015 mL | |
5 mM | 0.8220 mL | 4.1102 mL | 8.2203 mL | |
10 mM | 0.4110 mL | 2.0551 mL | 4.1102 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.