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Protein Tyrosine Kinase
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VEGFR
Signaling Pathways
Apoptosis
♦
Bcl-2
(
37
)
♦
p53
(
20
)
♦
Caspase
(
25
)
♦
TNFa
(
20
)
♦
Mdm2
(
22
)
♦
c-RET
(
4
)
♦
IAP
(
9
)
♦
PERK
(
4
)
♦
PD-1/PD-L1
(
15
)
♦
Survivin
(
3
)
♦
Apoptosis
(
89
)
♦
RIP kinase
(
18
)
♦
ROS
(
1
)
♦
Cytohesin
(
1
)
♦
Ras
(
3
)
♦
Thymidylate Synthase
(
4
)
♦
DAPK
(
1
)
♦
ASK
(
1
)
♦
FKBP
(
2
)
♦
Ferroptosis
(
9
)
♦
TRADD
(
1
)
♦
PKD
(
3
)
♦
c-Myc
(
2
)
♦
TNF Receptor
(
2
)
PI3K/Akt/mTOR
♦
PI3K
(
108
)
♦
Akt
(
41
)
♦
mTOR
(
31
)
♦
GSK-3
(
24
)
♦
ATM/ATR
(
3
)
♦
PDK-1
(
4
)
♦
S6 kinase
(
6
)
♦
AMPK
(
19
)
♦
DNA-PK
(
10
)
♦
PTEN
(
3
)
♦
PDPK1
(
3
)
♦
NUDIX
(
3
)
♦
PDHK
(
3
)
♦
PI4K
(
5
)
♦
PP2A
(
1
)
♦
MELK
(
4
)
♦
PIKfyve
(
1
)
Epigenetics
♦
HDAC
(
12
)
♦
HIF
(
7
)
♦
PARP
(
0
)
♦
JAK
(
56
)
♦
Aurora Kinase
(
24
)
♦
Histone Acetyltransferase
(
14
)
♦
Histone Demethylase
(
28
)
♦
Histone Methyltransferase
(
87
)
♦
DNA Methyltransferase
(
14
)
♦
Epigenetic Reader Domain
(
73
)
♦
Sirtuin
(
19
)
♦
Pim
(
6
)
♦
PKC
(
17
)
♦
SMYD
(
1
)
♦
MAT
(
5
)
♦
MicroRNA
(
2
)
♦
AMPK
(
6
)
♦
Protein Arginine Deiminase
(
3
)
♦
EZH1/2
(
1
)
♦
MLL
(
1
)
MAPK
♦
MEK
(
32
)
♦
ERK
(
31
)
♦
Raf
(
30
)
♦
JNK
(
22
)
♦
p38 MAPK
(
34
)
♦
RSK
(
5
)
♦
Mixed Lineage Kinase
(
5
)
♦
KLF
(
4
)
♦
MNK
(
4
)
♦
MAP4K
(
4
)
♦
MAP3K
(
2
)
♦
MK2
(
3
)
Protein Tyrosine Kinase
♦
VEGFR
(
80
)
♦
EGFR
(
65
)
♦
PDGFR
(
25
)
♦
c-MET
(
34
)
♦
HER-2
(
2
)
♦
ALK
(
24
)
♦
FLT3
(
17
)
♦
FGFR
(
29
)
♦
IFG-1R
(
11
)
♦
c-Kit
(
10
)
♦
Tie-2
(
1
)
♦
CSF-1R
(
4
)
♦
TAM Receptor
(
10
)
♦
Trk receptor
(
9
)
♦
c-RET
(
0
)
♦
Axl
(
2
)
♦
Bcr-Abl
(
10
)
♦
Ephrin Receptor
(
2
)
♦
Pyk2
(
1
)
♦
c-Fms
(
8
)
♦
DDR
(
1
)
♦
IGF-1R
(
0
)
♦
HER2
(
2
)
♦
Src
(
14
)
♦
Syk
(
10
)
♦
DYRK
(
5
)
♦
FAK
(
5
)
♦
Btk
(
23
)
♦
Itk
(
2
)
♦
Mertk
(
1
)
♦
RET
(
7
)
♦
SHP2
(
5
)
♦
Insulin Receptor
(
3
)
♦
ROS Kinase
(
1
)
♦
BMX Kinase
(
1
)
♦
Discoidin Domain Receptor
(
2
)
Angiogenesis
♦
VEGFR
(
1
)
♦
EGFR
(
1
)
♦
PDGFR
(
0
)
♦
HIF
(
5
)
♦
HER-2
(
1
)
♦
JAK
(
0
)
♦
FLT3
(
2
)
♦
FGFR
(
0
)
♦
BTK
(
14
)
♦
Syk
(
8
)
♦
FAK
(
8
)
♦
Src
(
9
)
♦
Bcr-Abl
(
11
)
♦
VDA
(
3
)
♦
ALK
(
1
)
♦
5-alpha Reductase
(
1
)
Proteases
♦
Proteasome
(
15
)
♦
Cysteine Protease
(
15
)
♦
Serine Protease
(
9
)
♦
Gamma-secretase
(
10
)
♦
HCV Protease
(
12
)
♦
HIV Protease
(
9
)
♦
MMP
(
10
)
♦
DPP-4
(
15
)
♦
Caspase
(
0
)
♦
Acyltransferase
(
1
)
♦
Tyrosinase
(
1
)
♦
Glutaminase
(
8
)
♦
Thrombin
(
8
)
♦
3C-Like Protease
(
1
)
♦
Neprilysin
(
2
)
NF-kB
♦
NOD1
(
2
)
♦
IκB/IKK
(
28
)
♦
NF-κB
(
59
)
♦
HDAC
(
0
)
♦
ROS
(
1
)
♦
Keap1-Nrf2
(
8
)
Autophagy
♦
Autophagy
(
62
)
♦
LRRK2
(
15
)
♦
ULK
(
6
)
♦
Mitophagy
(
1
)
♦
OGA
(
1
)
JAK/STAT
♦
JAK
(
13
)
♦
STAT
(
13
)
♦
EGFR
(
36
)
♦
Pim
(
14
)
Metabolism
♦
PDE
(
38
)
♦
P450 (e.g. CYP)
(
31
)
♦
PPAR
(
22
)
♦
Phospholipase
(
12
)
♦
DHFR
(
8
)
♦
Dehydrogenase
(
33
)
♦
HSP
(
22
)
♦
Carbonic Anhydrase
(
19
)
♦
MAO
(
5
)
♦
FAAH
(
12
)
♦
CETP
(
4
)
♦
Transferase
(
12
)
♦
HMG-CoA Reductase
(
11
)
♦
Hydroxylase
(
9
)
♦
IDO
(
12
)
♦
Retinoid Receptor
(
9
)
♦
Factor Xa
(
5
)
♦
AhR
(
7
)
♦
Ferroptosis
(
4
)
♦
Casein Kinase
(
14
)
♦
NAMPT
(
7
)
♦
Glucosylceramide Synthase
(
2
)
♦
Aldose Reductase
(
2
)
♦
ATP-citrate lyase
(
1
)
♦
Carbohydrate Metabolism
(
3
)
♦
FXR
(
12
)
♦
IAP
(
1
)
♦
Lipoxygenase
(
11
)
♦
Mitochondrial Metabolism
(
3
)
♦
PCSK9
(
4
)
♦
Phosphorylase
(
2
)
♦
Serine hydrolase
(
1
)
♦
SGK
(
2
)
♦
SCD
(
1
)
♦
Vitamin
(
15
)
♦
Acyltransferase
(
2
)
♦
CAR
(
2
)
♦
ROR
(
6
)
♦
PRMT
(
2
)
♦
PGC-1α
(
2
)
♦
Lipase
(
3
)
♦
OXPHOS
(
3
)
♦
Peroxidases
(
3
)
♦
Phosphatase
(
6
)
♦
Decarboxylase
(
4
)
♦
Prostaglandin Receptor
(
1
)
♦
Serine/threonin kinase
(
6
)
♦
Fatty Acid Synthase
(
6
)
♦
THR
(
4
)
♦
Glutathione
(
1
)
♦
CPT
(
2
)
♦
Acetyl-CoA Carboxylase
(
5
)
♦
AChR
(
2
)
♦
cGAS
(
2
)
♦
CPSase
(
1
)
♦
AdipoR
(
2
)
♦
GLUT
(
2
)
♦
PKM
(
3
)
♦
Mitochondrial pyruvate carrier
(
1
)
♦
ACSS2
(
1
)
♦
FABP
(
1
)
♦
Xanthine Oxidase
(
1
)
♦
Thrombopoietin Receptor
(
1
)
♦
Thioredoxin Reductase
(
1
)
♦
SHIP
(
1
)
Neuronal Signaling
♦
5-HT Receptor
(
5
)
♦
COX
(
42
)
♦
GluR
(
24
)
♦
Adrenergic Receptor
(
11
)
♦
AChR Receptor
(
63
)
♦
Histamine Receptor
(
8
)
♦
Dopamine Receptor
(
9
)
♦
Opioid Receptor
(
5
)
♦
GABA Receptor
(
19
)
♦
P-gp
(
0
)
♦
CaMK
(
12
)
♦
P2 Receptor
(
9
)
♦
OX Receptor
(
1
)
♦
MT Receptor
(
0
)
♦
BACE
(
3
)
♦
Gamma-secretase
(
0
)
♦
Beta Amyloid
(
19
)
♦
Monoamine Oxidase
(
13
)
♦
P2Y Receptor
(
1
)
♦
NMDAR
(
7
)
♦
γ-secretase
(
3
)
♦
Calcium Channel
(
6
)
♦
Serotonin Transporter
(
7
)
♦
Transthyretin (TTR)
(
2
)
♦
Notch
(
8
)
♦
ChE
(
10
)
♦
BChE
(
2
)
♦
Glucosylceramide Synthase
(
3
)
♦
AAK1
(
2
)
♦
Dopamine Transporter
(
4
)
♦
Sigma Receptor
(
15
)
♦
Tau Protein
(
1
)
♦
Beta-secretase
(
6
)
♦
Imidazoline Receptor
(
4
)
♦
Adenosine Kinase
(
2
)
♦
α-synuclein
(
1
)
Ubiquitin
♦
E2 conjugating
(
2
)
♦
p97
(
5
)
♦
E3 Ligase
(
11
)
♦
DUB
(
20
)
♦
Proteasome
(
0
)
♦
E1 Activating
(
5
)
♦
SUMO
(
1
)
Stem Cells/Wnt
♦
Hedgehog/Smoothened ROCK
(
5
)
♦
ROCK
(
0
)
♦
Wnt/beta-catenin
(
30
)
♦
Gamma-secretase
(
0
)
♦
Casein Kinase
(
4
)
♦
TGF–beta/Smad
(
1
)
♦
STAT
(
9
)
♦
JAK
(
0
)
♦
GSK-3
(
2
)
♦
Smo
(
5
)
♦
PKA
(
6
)
♦
Oct
(
3
)
♦
Porcupine
(
3
)
♦
Hippo (MST)
(
2
)
♦
YAP
(
5
)
♦
SFRP
(
1
)
♦
Stemness kinase
(
1
)
DNA Damage
♦
Telomerase
(
3
)
♦
Topoisomerase
(
54
)
♦
DNA/RNA Synthesis
(
115
)
♦
HDAC
(
52
)
♦
ATM/ATR
(
18
)
♦
PARP
(
51
)
♦
Sirtuin
(
7
)
♦
DNA Stain
(
4
)
♦
Nucleoside Antimetabolite/Analog
(
7
)
♦
DNA alkylator
(
10
)
♦
p97
(
3
)
♦
CRISPR/Cas9
(
1
)
♦
SMN
(
1
)
♦
HSP
(
11
)
♦
RNR
(
2
)
♦
OGG1
(
2
)
♦
RAD51
(
4
)
♦
PARG
(
1
)
GPCR & G Protein
♦
cAMP
(
8
)
♦
Adenosine Receptor
(
38
)
♦
Vasopressin Receptor
(
8
)
♦
CXCR
(
35
)
♦
CaSR
(
8
)
♦
PAFR
(
2
)
♦
CGRP Receptor
(
6
)
♦
LPA Receptor
(
2
)
♦
SGLT
(
8
)
♦
S1P Receptor
(
12
)
♦
Endothelin Receptor
(
13
)
♦
Cannabinoid Receptor
(
24
)
♦
5-HT Receptor
(
140
)
♦
Adrenergic Receptor
(
113
)
♦
Histamine Receptor
(
76
)
♦
Dopamine Receptor
(
77
)
♦
Opioid Receptor
(
29
)
♦
Hedgehog/Smoothened ROCK
(
11
)
♦
OX Receptor
(
23
)
♦
MT Receptor
(
2
)
♦
Guanylate Cyclase
(
15
)
♦
LPL Receptor
(
18
)
♦
NPY receptor
(
1
)
♦
Angiotensin Receptor
(
21
)
♦
Free Fatty Acid Receptor
(
10
)
♦
GnRH Receptor
(
10
)
♦
GPR
(
21
)
♦
Leukotriene Receptor
(
8
)
♦
mAChR
(
32
)
♦
Neurotensin Receptor
(
4
)
♦
Prostaglandin Receptor
(
40
)
♦
Sigma Receptor
(
1
)
♦
PAR
(
10
)
♦
CCR
(
21
)
♦
GCGR
(
27
)
♦
GHSR
(
6
)
♦
GPCR19
(
3
)
♦
LTR
(
1
)
♦
mGluR
(
29
)
♦
PKD
(
2
)
♦
Ras
(
22
)
♦
CCK receptor
(
4
)
♦
Melatonin Receptor
(
5
)
♦
Formyl Peptide Receptor
(
2
)
♦
G protein-coupled Bile Acid Receptor
(
2
)
♦
Melanocortin Receptor
(
5
)
♦
Neurokinin Receptor
(
12
)
♦
Oxytocin Receptor
(
3
)
♦
Somatostatin Receptor
(
3
)
♦
Adenylate Cyclase
(
3
)
♦
Bradykinin Receptor
(
3
)
♦
P2Y Receptor
(
7
)
♦
Urotensin Receptor
(
1
)
♦
TSH Receptor
(
2
)
♦
PKG
(
2
)
♦
RGS Protein
(
3
)
♦
Glucagon Receptor
(
2
)
♦
TAAR
(
1
)
♦
Neuropeptide Y Receptor
(
5
)
♦
Motilin Receptor
(
1
)
♦
CRFR
(
3
)
♦
APJ
(
1
)
♦
EBI2
(
1
)
♦
Bombesin Receptor
(
2
)
♦
GPR109A
(
2
)
♦
MRGPR
(
2
)
TGF-beta/Smad
♦
MT Receptor
(
20
)
♦
Bcr-Abl
(
0
)
♦
ROCK
(
23
)
♦
PKC
(
16
)
♦
TGF-β Receptor
(
13
)
♦
TGF-beta/Smad
(
6
)
Cell Cycle
♦
CDK
(
105
)
♦
Rho
(
19
)
♦
PLK
(
19
)
♦
Chk
(
12
)
♦
Aurora Kinase
(
7
)
♦
ROCK
(
8
)
♦
PD-1/PD-L1
(
0
)
♦
c-Myc
(
6
)
♦
Wee1
(
2
)
♦
APC
(
3
)
♦
HSP
(
6
)
♦
Microtubule/Tubulin
(
39
)
♦
HDAC
(
18
)
♦
PPAR
(
24
)
♦
Eukaryotic Initiation Factor
(
5
)
♦
Topoisomerase
(
13
)
♦
Ras
(
5
)
♦
Mps1
(
5
)
♦
Kinesin
(
8
)
♦
PAK
(
5
)
♦
PERK
(
1
)
♦
Antifolate
(
3
)
♦
TOPK
(
5
)
♦
PARP
(
0
)
♦
LIMK
(
5
)
♦
G-quadruplex
(
2
)
♦
PFKFB
(
4
)
♦
BMI-1
(
2
)
♦
Mad2
(
1
)
♦
Nur77
(
2
)
♦
p21
(
1
)
♦
SRPK
(
2
)
Cytoskeletal Signaling
♦
Bcr-Abl
(
1
)
♦
Wnt/beta-catenin
(
10
)
♦
PKC
(
0
)
♦
FAK
(
0
)
♦
HSP
(
3
)
♦
Dynamin
(
3
)
♦
PAK
(
4
)
♦
Integrin
(
28
)
♦
Microtubule Associated
(
26
)
♦
Kinesin
(
6
)
♦
MLCK
(
2
)
♦
Gap Junction Protein
(
5
)
♦
Myosin
(
3
)
♦
Cardiac Myosin
(
1
)
♦
Arp2/3 Complex
(
1
)
♦
TACC3
(
1
)
Transmembrane
♦
P-gp
(
11
)
♦
Proton Pump
(
18
)
♦
GABA Receptor
(
38
)
♦
Sodium Channel
(
64
)
♦
Potassium Channel
(
75
)
♦
Calcium Channel
(
82
)
♦
ATPase
(
14
)
♦
CRM1
(
2
)
♦
TRPV
(
0
)
♦
CFTR
(
9
)
♦
OCT
(
0
)
♦
Amino Acid Transporter
(
2
)
♦
Monocarboxylate Transporter
(
4
)
♦
Apical Sodium-Dependent Bile Acid Transporter
(
3
)
♦
Chloride Channel
(
6
)
♦
GlyT
(
3
)
♦
P2 Receptor
(
2
)
♦
TRP Channel
(
42
)
♦
BCRP
(
3
)
♦
CD markers
(
4
)
♦
HCN Channel
(
3
)
♦
iGluR
(
37
)
♦
Interleukins
(
1
)
♦
nAChR
(
20
)
♦
OAT
(
1
)
♦
SGLT
(
9
)
♦
Monocarboxylate Transporter
(
2
)
♦
Adrenergic Receptor
(
1
)
♦
P2X Receptor
(
9
)
♦
CRAC Channel
(
3
)
♦
Monoamine Transporter
(
6
)
♦
Piezo Channel
(
2
)
♦
Aquaporin
(
2
)
♦
EAAT
(
2
)
♦
NKCC
(
1
)
♦
VDAC
(
4
)
♦
NHE
(
3
)
♦
URAT1
(
4
)
♦
Na+/K+ ATPase
(
2
)
♦
Na+/Ca2+ Exchanger
(
2
)
♦
ATP Synthase
(
1
)
♦
Calmodulin
(
1
)
♦
MTP
(
2
)
♦
Na+/HCO3- Cotransporter
(
1
)
Endocrinology & Hormones
♦
Opioid Receptor
(
0
)
♦
Glucocorticoid Receptor
(
7
)
♦
Estrogen/progestogen Receptor
(
49
)
♦
Androgen Receptor
(
23
)
♦
RAAS
(
27
)
♦
Aromatase
(
6
)
♦
GPR
(
9
)
♦
5-alpha Reductase
(
2
)
♦
Adrenergic Receptor
(
2
)
♦
Mineralocorticoid Receptor
(
3
)
♦
ACE
(
3
)
♦
TSH Receptor
(
2
)
♦
THR
(
1
)
Microbiology
♦
HCV Protease
(
0
)
♦
HIV Protease
(
2
)
♦
CCR
(
2
)
♦
Reverse Transcriptase
(
35
)
♦
Integrase
(
1
)
♦
Bacterial
(
13
)
♦
Anti-infection
(
7
)
♦
HSV
(
1
)
♦
Influenza Virus
(
2
)
♦
RSV
(
1
)
♦
β-lactamase
(
1
)
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Antibiotics
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6
)
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Antiviral
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6
)
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Parasite
(
8
)
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11
)
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CMV
(
4
)
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COVID-19
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3
)
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19
)
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37
)
♦
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(
1
)
♦
LOX-1
(
1
)
♦
gp120/CD4
(
1
)
♦
FXR
(
0
)
♦
PKA
(
0
)
♦
Thrombin
(
0
)
♦
Liver X receptor
(
0
)
♦
IL Receptor
(
0
)
♦
Others 1
(
57
)
♦
Others 2
(
86
)
♦
Others 3
(
17
)
♦
Others 4
(
41
)
♦
Others 5
(
39
)
♦
Others 6
(
156
)
♦
Others 7
(
47
)
New Products
♦
New1
(
2381
)
♦
New2
(
6627
)
♦
New3
(
3584
)
♦
New4
(
21
)
♦
New5
(
4520
)
♦
New6
(
3591
)
♦
New7
(
3410
)
♦
New8
(
4590
)
♦
New9
(
3614
)
♦
New10
(
1380
)
♦
New11
(
3393
)
♦
New12
(
2495
)
Immunology/Inflammation
♦
STING
(
22
)
♦
Glucocorticoid Receptor
(
16
)
♦
Arginase
(
3
)
♦
TLR
(
31
)
♦
IRAK
(
9
)
♦
Reactive Oxygen Species
(
33
)
♦
ROS
(
7
)
♦
COX
(
36
)
♦
Prostaglandin Receptor
(
2
)
♦
MIF
(
1
)
♦
Nrf2
(
4
)
♦
AKR1C
(
2
)
♦
Antibiotics
(
1
)
♦
Galectin
(
2
)
♦
IFN
(
1
)
♦
SPHK
(
6
)
♦
Interleukins
(
11
)
♦
NO Synthase
(
7
)
♦
PGE synthase
(
8
)
♦
SIK
(
3
)
♦
Immunology & Inflammation related
(
13
)
♦
PKR
(
1
)
♦
PD-1/PD-L1
(
10
)
♦
NLRP3
(
1
)
♦
Complement System
(
9
)
♦
TBK1
(
2
)
♦
NFAT
(
1
)
♦
cGAS
(
1
)
♦
LTR
(
2
)
♦
AP-1
(
2
)
♦
NLR
(
4
)
♦
FLAP
(
5
)
♦
Aryl Hydrocarbon Receptor
(
5
)
♦
Thrombopoietin Receptor
(
5
)
♦
MALT
(
1
)
♦
MyD88
(
1
)
♦
CD28
(
1
)
ADC Related
♦
ADC Linker
(
16
)
♦
ADC Cytotoxin
(
7
)
♦
Drug-Linker Conjugates for ADC
(
10
)
Metabolic Enzyme/Protease
♦
Phosphodiesterase(PDE)
(
44
)
♦
Aminopeptidase
(
5
)
♦
Endogenous Metabolite
(
111
)
♦
Phospholipase
(
15
)
♦
ALDH
(
3
)
♦
Cytochrome P450
(
21
)
♦
Dipeptidyl Peptidase
(
6
)
♦
Drug Metabolite
(
32
)
♦
Farnesyl Transferase
(
5
)
♦
HIF/HIF Prolyl-Hydroxylase
(
16
)
♦
Lactate Dehydrogenase
(
4
)
♦
Mitochondrial Metabolism
(
14
)
♦
MMP
(
16
)
♦
PAI-1
(
5
)
♦
PDI
(
2
)
♦
RAR/RXR
(
12
)
♦
REV-ERB
(
2
)
♦
ROR
(
5
)
♦
Thrombin
(
6
)
♦
11β-HSD
(
5
)
♦
MAGL
(
5
)
♦
TrxR
(
1
)
♦
Tyrosinase
(
6
)
♦
Glucokinase
(
5
)
♦
Phosphatase
(
28
)
♦
Aldose Reductase
(
8
)
♦
Carbonic Anhydrase
(
1
)
♦
Epoxide Hydrolase
(
4
)
♦
Mineralocorticoid Receptor
(
3
)
♦
ACE
(
6
)
♦
SCD
(
7
)
♦
FXR
(
5
)
♦
LXR
(
12
)
♦
DGK
(
1
)
♦
FTO
(
2
)
♦
DHODH
(
1
)
♦
HMGCR
(
5
)
♦
FASN
(
9
)
♦
Renin
(
2
)
♦
Liposome
(
8
)
♦
NADPH Oxidase
(
6
)
♦
Glucosidase
(
11
)
♦
HIV Protease
(
1
)
♦
Factor Xa
(
6
)
♦
Acyltransferase
(
5
)
♦
Glutathione Peroxidase
(
5
)
♦
Gutathione S-transferase
(
2
)
♦
5 alpha Reductase
(
2
)
♦
Tryptophan Hydroxylase
(
3
)
♦
Procollagen C Proteinase
(
1
)
♦
Dopamine β-hydroxylase
(
2
)
♦
NEDD8-activating Enzyme
(
3
)
♦
Reactive Oxygen Species
(
1
)
♦
Adenosine Deaminase
(
2
)
♦
Acetyl-CoA Carboxylase
(
4
)
♦
ATP Citrate Lyase
(
3
)
♦
IDO
(
2
)
♦
MTHFD
(
1
)
♦
Neprilysin
(
2
)
♦
PHGDH
(
1
)
♦
Proteasome
(
5
)
♦
Ser/Thr Protease
(
3
)
♦
PREP
(
2
)
♦
Elastase
(
8
)
♦
IDH
(
5
)
♦
Adiponectin Receptor
(
1
)
♦
Dihydroorotate Dehydrogenase
(
4
)
♦
ATGL
(
1
)
♦
Cathepsin
(
3
)
♦
FBPase
(
1
)
♦
GSNOR
(
1
)
♦
Ceramidase
(
1
)
♦
Hexokinase
(
1
)
♦
HIV Integrase
(
1
)
♦
Pyruvate Kinase
(
1
)
♦
Xanthine Oxidase
(
1
)
♦
E1/E2/E3 Enzyme
(
1
)
Anti-infection
♦
HSV
(
8
)
♦
Fungal
(
44
)
♦
Influenza Virus
(
34
)
♦
Bacterial
(
270
)
♦
HBV
(
16
)
♦
HCV Protease
(
5
)
♦
HIV
(
29
)
♦
RABV
(
1
)
♦
Parasite
(
44
)
♦
Antibiotic
(
16
)
♦
Reverse Transcriptase
(
4
)
♦
Virus Protease
(
3
)
♦
SARS-CoV
(
19
)
♦
RSV
(
2
)
♦
CMV
(
3
)
♦
Gli
(
1
)
♦
Arenavirus
(
1
)
♦
Enterovirus
(
6
)
♦
HCV
(
26
)
♦
Filovirus
(
3
)
Vitamin D Related/Nuclear Receptor
♦
Progesterone Receptor
(
8
)
♦
Glucocorticoid Receptor
(
1
)
♦
ERR
(
30
)
♦
Thyroid Hormone Receptor
(
6
)
♦
Androgen Receptor
(
14
)
♦
VD/VDR
(
19
)
PROTAC
♦
PROTAC Linkers
(
44
)
♦
E3 Ligase Ligand-Linker Conjugates
(
8
)
♦
Ligands for E3 Ligase
(
11
)
♦
Ligands for Target Protein for PROTAC
(
2
)
♦
ATTECs
(
1
)
♦
Molecular Glues
(
2
)
Unfolded Protein Response
♦
Deubiquitinase
(
4
)
♦
IRE1
(
8
)
♦
PDI
(
1
)
♦
Eukaryotic Initiation Factor
(
2
)
Methylation
♦
NNMT
(
1
)
Product Type
Natural Products
♦
Plants
(
63
)
♦
Disease Research Fields
(
50
)
♦
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(
3
)
♦
Terpenoids
(
1
)
♦
Phenols
(
1
)
♦
Flavonoids
(
1
)
♦
Natural Products 1
(
419
)
Peptides
♦
Peptides 1
(
1984
)
Antibodies
Amino Acids
♦
Amino Acids 1
(
384
)
PROTACs
♦
PROTACs 1
(
50
)
Fine Intermediates/Building Blocks
Others
Bulletin Board
BMS-794833
Catalog No：
V0501
CAS No. (CAS Registry Number)：
1174046-72-0
Price：
$0/g
Description: BMS-794833 (BMS794833; BMS 794833) is an ATP competitive multi-kinase (Met/VEGFR2) inhibitor with potential anticancer activity. It inhibits Met/VEGFR2 with IC50s of 1.7 nM and 15 nM...
Ki8751
Catalog No：
V0502
CAS No. (CAS Registry Number)：
228559-41-9
Price：
$0/g
Description: Ki8751 (Ki-8751), a quinolyloxyphenyl-urea analog, is a novel, cell-permeable and selective inhibitor of VEGFR2 (Flk-1) with potential anticancer activity. I...
Apatinib (Rivoceranib, YN968D1)
Catalog No：
V0503
CAS No. (CAS Registry Number)：
811803-05-1 (free base)
Price：
$0/g
Description: Apatinib (formerly known as Rivoceranib, YN-968D1) is a potent, orally bioavailable, and selective inhibitor of the VEGF (vascular endothelial growth factor receptor) signaling ...
Tivozanib (AV951; KRN-951)
Catalog No：
V0505
CAS No. (CAS Registry Number)：
475108-18-0
Price：
$0/g
Description: Tivozanib (formerly KRN951 or AV-951; brand name Fotivda) is a novel, orally bioavailable, potent and selective inhibitor of VEGFR (vascular endothelial growth factor recep...
Brivanib (BMS-540215)
Catalog No：
V0506
CAS No. (CAS Registry Number)：
649735-46-6
Price：
$0/g
Description: Brivanib (formerly BMS-540215; BMS540215) is a novel, investigational, oral and ATP-competitive inhibitor of VEGFR2 with potential anticancer activity. It inhibi...
Dovitinib (TKI-258, CHIR-258)
Catalog No：
V0507
CAS No. (CAS Registry Number)：
405169-16-6
Price：
$0/g
Description: Dovitinib (formerly TKI258 and CHIR258) is a potent, orally bioavailable and multi-targeted RTK (receptor tyrosine kinase) inhibitor with potential anticancer activity....
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