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Signaling Pathways
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PLK
Signaling Pathways
Apoptosis
♦
Bcl-2
(
11
)
♦
p53
(
11
)
♦
Caspase
(
10
)
♦
TNFa
(
4
)
♦
Mdm2
(
14
)
♦
c-RET
(
4
)
♦
IAP
(
6
)
♦
PERK
(
4
)
♦
PD-1/PD-L1
(
11
)
♦
Survivin
(
1
)
PI3K/Akt/mTOR
♦
PI3K
(
61
)
♦
Akt
(
18
)
♦
mTOR
(
21
)
♦
GSK-3
(
15
)
♦
ATM/ATR
(
0
)
♦
PDK-1
(
4
)
♦
S6 kinase
(
6
)
♦
AMPK
(
8
)
♦
DNA-PK
(
3
)
Epigenetics
♦
HDAC
(
0
)
♦
HIF
(
8
)
♦
PARP
(
0
)
♦
JAK
(
34
)
♦
Aurora Kinase
(
23
)
♦
Histone Acetyltransferase
(
5
)
♦
Histone Demethylase
(
9
)
♦
Histone Methyltransferase
(
26
)
♦
DNA Methyltransferase
(
8
)
♦
Epigenetic Reader Domain
(
19
)
♦
Sirtuin
(
11
)
♦
Pim
(
6
)
MAPK
♦
MEK
(
18
)
♦
ERK
(
8
)
♦
Raf
(
15
)
♦
JNK
(
7
)
♦
p38 MAPK
(
13
)
Protein Tyrosine Kinase
♦
VEGFR
(
46
)
♦
EGFR
(
39
)
♦
PDGFR
(
11
)
♦
c-MET
(
14
)
♦
HER-2
(
2
)
♦
ALK
(
10
)
♦
FLT3
(
8
)
♦
FGFR
(
10
)
♦
IFG-1R
(
8
)
♦
c-Kit
(
3
)
♦
Tie-2
(
1
)
♦
CSF-1R
(
2
)
♦
TAM Receptor
(
6
)
♦
Trk receptor
(
3
)
♦
c-RET
(
0
)
Angiogenesis
♦
VEGFR
(
0
)
♦
EGFR
(
0
)
♦
PDGFR
(
0
)
♦
HIF
(
0
)
♦
HER-2
(
0
)
♦
JAK
(
0
)
♦
FLT3
(
0
)
♦
FGFR
(
0
)
♦
BTK
(
7
)
♦
Syk
(
6
)
♦
FAK
(
8
)
♦
Src
(
8
)
♦
Bcr-Abl
(
10
)
♦
VDA
(
3
)
Proteases
♦
Proteasome
(
13
)
♦
Cysteine Protease
(
11
)
♦
Serine Protease
(
5
)
♦
Gamma-secretase
(
10
)
♦
HCV Protease
(
5
)
♦
HIV Protease
(
7
)
♦
MMP
(
6
)
♦
DPP-4
(
8
)
♦
Caspase
(
0
)
NF-kB
♦
NOD1
(
2
)
♦
IκB/IKK
(
14
)
♦
NF-κB
(
6
)
♦
HDAC
(
0
)
Autophagy
♦
Autophagy
(
20
)
♦
LRRK2
(
5
)
JAK/STAT
♦
JAK
(
0
)
♦
STAT
(
0
)
♦
EGFR
(
0
)
♦
Pim
(
0
)
Metabolism
♦
PDE
(
26
)
♦
P450 (e.g. CYP)
(
24
)
♦
PPAR
(
16
)
♦
Phospholipase
(
7
)
♦
DHFR
(
5
)
♦
Dehydrogenase
(
20
)
♦
HSP
(
20
)
♦
Carbonic Anhydrase
(
16
)
♦
MAO
(
0
)
♦
FAAH
(
5
)
♦
CETP
(
4
)
♦
Transferase
(
8
)
♦
HMG-CoA Reductase
(
11
)
♦
Hydroxylase
(
8
)
♦
IDO
(
4
)
♦
Retinoid Receptor
(
5
)
♦
Factor Xa
(
4
)
♦
AhR
(
3
)
♦
Ferroptosis
(
3
)
♦
Casein Kinase
(
3
)
♦
NAMPT
(
3
)
Neuronal Signaling
♦
5-HT Receptor
(
0
)
♦
COX
(
40
)
♦
GluR
(
16
)
♦
Adrenergic Receptor
(
0
)
♦
AChR Receptor
(
47
)
♦
Histamine Receptor
(
0
)
♦
Dopamine Receptor
(
0
)
♦
Opioid Receptor
(
0
)
♦
GABA Receptor
(
0
)
♦
P-gp
(
0
)
♦
CaMK
(
8
)
♦
P2 Receptor
(
7
)
♦
OX Receptor
(
0
)
♦
MT Receptor
(
0
)
♦
BACE
(
2
)
♦
Gamma-secretase
(
0
)
♦
Beta Amyloid
(
1
)
Ubiquitin
♦
E2 conjugating
(
1
)
♦
p97
(
3
)
♦
E3 Ligase
(
0
)
♦
DUB
(
8
)
♦
Proteasome
(
0
)
Stem Cells/Wnt
♦
Hedgehog/Smoothened ROCK
(
0
)
♦
ROCK
(
0
)
♦
Wnt/beta-catenin
(
0
)
♦
Gamma-secretase
(
0
)
♦
Casein Kinase
(
0
)
♦
TGF–beta/Smad
(
0
)
♦
STAT
(
9
)
♦
JAK
(
0
)
♦
GSK-3
(
0
)
DNA Damage
♦
Telomerase
(
2
)
♦
Topoisomerase
(
36
)
♦
DNA/RNA Synthesis
(
65
)
♦
HDAC
(
38
)
♦
ATM/ATR
(
14
)
♦
PARP
(
27
)
♦
Sirtuin
(
0
)
GPCR & G Protein
♦
cAMP
(
1
)
♦
Adenosine Receptor
(
4
)
♦
Vasopressin Receptor
(
3
)
♦
CXCR
(
3
)
♦
CaSR
(
2
)
♦
PAFR
(
2
)
♦
CGRP Receptor
(
1
)
♦
LPA Receptor
(
2
)
♦
SGLT
(
4
)
♦
S1P Receptor
(
6
)
♦
Endothelin Receptor
(
7
)
♦
Cannabinoid Receptor
(
7
)
♦
5-HT Receptor
(
63
)
♦
Adrenergic Receptor
(
65
)
♦
Histamine Receptor
(
41
)
♦
Dopamine Receptor
(
28
)
♦
Opioid Receptor
(
9
)
♦
Hedgehog/Smoothened ROCK
(
11
)
♦
OX Receptor
(
7
)
♦
MT Receptor
(
2
)
TGF-beta/Smad
♦
MT Receptor
(
20
)
♦
Bcr-Abl
(
0
)
♦
ROCK
(
20
)
♦
PKC
(
9
)
Cell Cycle
♦
CDK
(
36
)
♦
Rho
(
13
)
♦
PLK
(
10
)
♦
Chk
(
6
)
♦
Aurora Kinase
(
0
)
♦
ROCK
(
0
)
♦
PD-1/PD-L1
(
0
)
♦
c-Myc
(
2
)
♦
Wee1
(
1
)
♦
APC
(
1
)
Cytoskeletal Signaling
♦
Bcr-Abl
(
1
)
♦
Wnt/beta-catenin
(
10
)
♦
PKC
(
1
)
♦
FAK
(
0
)
♦
HSP
(
0
)
♦
Dynamin
(
3
)
♦
PAK
(
3
)
♦
Integrin
(
8
)
♦
Microtubule Associated
(
24
)
♦
Kinesin
(
6
)
Transmembrane
♦
P-gp
(
6
)
♦
Proton Pump
(
10
)
♦
GABA Receptor
(
11
)
♦
Sodium Channel
(
27
)
♦
Potassium Channel
(
16
)
♦
Calcium Channel
(
29
)
♦
ATPase
(
0
)
♦
CRM1
(
1
)
♦
TRPV
(
0
)
♦
CFTR
(
0
)
♦
OCT
(
0
)
Endocrinology & Hormones
♦
Opioid Receptor
(
0
)
♦
Glucocorticoid Receptor
(
5
)
♦
Estrogen/progestogen Receptor
(
34
)
♦
Androgen Receptor
(
13
)
♦
RAAS
(
27
)
♦
Aromatase
(
5
)
♦
GPR
(
5
)
♦
5-alpha Reductase
(
2
)
Microbiology
♦
HCV Protease
(
0
)
♦
HIV Protease
(
0
)
♦
CCR
(
1
)
♦
Reverse Transcriptase
(
26
)
♦
Integrase
(
0
)
Others
♦
gp120/CD4
(
2
)
♦
FXR
(
4
)
♦
PKA
(
2
)
♦
Thrombin
(
4
)
♦
Liver X receptor
(
3
)
♦
IL Receptor
(
0
)
♦
Others 1
(
355
)
♦
Others 2
(
434
)
♦
Others 3
(
339
)
♦
Others 4
(
300
)
♦
Others 5
(
249
)
♦
Others 6
(
191
)
♦
Others 7
(
231
)
New Products
♦
New1
(
28819
)
♦
New2
(
3408
)
♦
New3
(
861
)
Product Type
Natural Products
♦
Natural Products 1
(
444
)
Peptides
♦
Peptides 1
(
2000
)
Antibodies
Amino Acids
♦
Amino Acids 1
(
389
)
PROTACs
♦
PROTACs 1
(
42
)
Fine Intermediates/Building Blocks
Others
BI 2536
Catalog No：
V1573
CAS No. (CAS Registry Number)：
755038-02-9
Price：
$0/g
Description: BI2536 is a novel and potent small molecule dual PLK1 and BRD4 inhibitor with IC50s of 0.83 and 25 nM, respectively in a cell-free assay. BI-2536 suppresses IFNB (encoding IFN-β) gen...
Volasertib (BI 6727)
Catalog No：
V1574
CAS No. (CAS Registry Number)：
755038-65-4
Price：
$0/g
Description: Volasertib (formerly also known as BI 6727) is a novel and highly potent dihydropteridinone Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selec...
Rigosertib sodium (ON-01910)
Catalog No：
V1575
CAS No. (CAS Registry Number)：
1225497-78-8
Price：
$0/g
Description: Rigosertib sodium (formerly also known as ON-01910), the sodium salt of Rigosertib, is a novel, potent and non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assa...
GSK461364
Catalog No：
V1576
CAS No. (CAS Registry Number)：
929095-18-1
Price：
$0/g
Description: GSK-461364 is a novel, potent, selective, reversible and ATP-competitive small molecule Polo-like kinase 1 (PLK1) inhibitor with a Ki value of 2.2 nM. GSK-46...
HMN-214
Catalog No：
V1577
CAS No. (CAS Registry Number)：
173529-46-9
Price：
$0/g
Description: HMN-214 is a potent and orally active prodrug of HMN-176, which alters the cellular spatial orientation of Plk1. HMN-214 is a stilbene derivative that interferes with the subcellular spat...
MLN0905
Catalog No：
V1578
CAS No. (CAS Registry Number)：
1228960-69-7
Price：
$0/g
Description: MLN0905 is a novel, potent and selective small-molecule inhibitor of PLK1 with IC50 of 2 nM. MLN0905 inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell...
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Products
Signaling Pathways
Product Type
About Us
About us
QC & QA
Services
Custom Organic Synthesis
Custom Peptide Synthesis
Analytical Service
Tools
Distributors
Contact Us
Contact Us
Order Info
How to Order
Safe Shopping
Shipping Policy
Return Policy
Customer Service
Terms & Conditions
Private Policy
Get a W-9 Form
Sitemap
Frequently Asked Questions
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