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Home
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Signaling Pathways
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Metabolic Enzyme/Protease
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MMP
Signaling Pathways
Apoptosis
♦
Bcl-2
(
37
)
♦
p53
(
20
)
♦
Caspase
(
25
)
♦
TNFa
(
20
)
♦
Mdm2
(
22
)
♦
c-RET
(
4
)
♦
IAP
(
9
)
♦
PERK
(
4
)
♦
PD-1/PD-L1
(
15
)
♦
Survivin
(
3
)
♦
Apoptosis
(
89
)
♦
RIP kinase
(
18
)
♦
ROS
(
1
)
♦
Cytohesin
(
1
)
♦
Ras
(
3
)
♦
Thymidylate Synthase
(
4
)
♦
DAPK
(
1
)
♦
ASK
(
1
)
♦
FKBP
(
2
)
♦
Ferroptosis
(
9
)
♦
TRADD
(
1
)
♦
PKD
(
3
)
♦
c-Myc
(
2
)
♦
TNF Receptor
(
2
)
PI3K/Akt/mTOR
♦
PI3K
(
108
)
♦
Akt
(
41
)
♦
mTOR
(
31
)
♦
GSK-3
(
24
)
♦
ATM/ATR
(
3
)
♦
PDK-1
(
4
)
♦
S6 kinase
(
6
)
♦
AMPK
(
19
)
♦
DNA-PK
(
10
)
♦
PTEN
(
3
)
♦
PDPK1
(
3
)
♦
NUDIX
(
3
)
♦
PDHK
(
3
)
♦
PI4K
(
5
)
♦
PP2A
(
1
)
♦
MELK
(
4
)
♦
PIKfyve
(
1
)
Epigenetics
♦
HDAC
(
12
)
♦
HIF
(
7
)
♦
PARP
(
0
)
♦
JAK
(
56
)
♦
Aurora Kinase
(
24
)
♦
Histone Acetyltransferase
(
14
)
♦
Histone Demethylase
(
28
)
♦
Histone Methyltransferase
(
87
)
♦
DNA Methyltransferase
(
14
)
♦
Epigenetic Reader Domain
(
73
)
♦
Sirtuin
(
19
)
♦
Pim
(
6
)
♦
PKC
(
17
)
♦
SMYD
(
1
)
♦
MAT
(
5
)
♦
MicroRNA
(
2
)
♦
AMPK
(
6
)
♦
Protein Arginine Deiminase
(
3
)
♦
EZH1/2
(
1
)
♦
MLL
(
1
)
MAPK
♦
MEK
(
32
)
♦
ERK
(
31
)
♦
Raf
(
30
)
♦
JNK
(
22
)
♦
p38 MAPK
(
34
)
♦
RSK
(
5
)
♦
Mixed Lineage Kinase
(
5
)
♦
KLF
(
4
)
♦
MNK
(
4
)
♦
MAP4K
(
4
)
♦
MAP3K
(
2
)
♦
MK2
(
3
)
Protein Tyrosine Kinase
♦
VEGFR
(
80
)
♦
EGFR
(
65
)
♦
PDGFR
(
25
)
♦
c-MET
(
34
)
♦
HER-2
(
2
)
♦
ALK
(
24
)
♦
FLT3
(
17
)
♦
FGFR
(
29
)
♦
IFG-1R
(
11
)
♦
c-Kit
(
10
)
♦
Tie-2
(
1
)
♦
CSF-1R
(
4
)
♦
TAM Receptor
(
10
)
♦
Trk receptor
(
9
)
♦
c-RET
(
0
)
♦
Axl
(
2
)
♦
Bcr-Abl
(
10
)
♦
Ephrin Receptor
(
2
)
♦
Pyk2
(
1
)
♦
c-Fms
(
8
)
♦
DDR
(
1
)
♦
IGF-1R
(
0
)
♦
HER2
(
2
)
♦
Src
(
14
)
♦
Syk
(
10
)
♦
DYRK
(
5
)
♦
FAK
(
5
)
♦
Btk
(
23
)
♦
Itk
(
2
)
♦
Mertk
(
1
)
♦
RET
(
7
)
♦
SHP2
(
5
)
♦
Insulin Receptor
(
3
)
♦
ROS Kinase
(
1
)
♦
BMX Kinase
(
1
)
♦
Discoidin Domain Receptor
(
2
)
Angiogenesis
♦
VEGFR
(
1
)
♦
EGFR
(
1
)
♦
PDGFR
(
0
)
♦
HIF
(
5
)
♦
HER-2
(
1
)
♦
JAK
(
0
)
♦
FLT3
(
2
)
♦
FGFR
(
0
)
♦
BTK
(
14
)
♦
Syk
(
8
)
♦
FAK
(
8
)
♦
Src
(
9
)
♦
Bcr-Abl
(
11
)
♦
VDA
(
3
)
♦
ALK
(
1
)
♦
5-alpha Reductase
(
1
)
Proteases
♦
Proteasome
(
15
)
♦
Cysteine Protease
(
15
)
♦
Serine Protease
(
9
)
♦
Gamma-secretase
(
10
)
♦
HCV Protease
(
12
)
♦
HIV Protease
(
9
)
♦
MMP
(
10
)
♦
DPP-4
(
15
)
♦
Caspase
(
0
)
♦
Acyltransferase
(
1
)
♦
Tyrosinase
(
1
)
♦
Glutaminase
(
8
)
♦
Thrombin
(
8
)
♦
3C-Like Protease
(
1
)
♦
Neprilysin
(
2
)
NF-kB
♦
NOD1
(
2
)
♦
IκB/IKK
(
28
)
♦
NF-κB
(
59
)
♦
HDAC
(
0
)
♦
ROS
(
1
)
♦
Keap1-Nrf2
(
8
)
Autophagy
♦
Autophagy
(
63
)
♦
LRRK2
(
15
)
♦
ULK
(
6
)
♦
Mitophagy
(
1
)
♦
OGA
(
1
)
JAK/STAT
♦
JAK
(
13
)
♦
STAT
(
13
)
♦
EGFR
(
36
)
♦
Pim
(
14
)
Metabolism
♦
PDE
(
38
)
♦
P450 (e.g. CYP)
(
31
)
♦
PPAR
(
22
)
♦
Phospholipase
(
12
)
♦
DHFR
(
8
)
♦
Dehydrogenase
(
33
)
♦
HSP
(
22
)
♦
Carbonic Anhydrase
(
19
)
♦
MAO
(
5
)
♦
FAAH
(
12
)
♦
CETP
(
4
)
♦
Transferase
(
12
)
♦
HMG-CoA Reductase
(
11
)
♦
Hydroxylase
(
9
)
♦
IDO
(
12
)
♦
Retinoid Receptor
(
9
)
♦
Factor Xa
(
5
)
♦
AhR
(
7
)
♦
Ferroptosis
(
4
)
♦
Casein Kinase
(
14
)
♦
NAMPT
(
7
)
♦
Glucosylceramide Synthase
(
2
)
♦
Aldose Reductase
(
2
)
♦
ATP-citrate lyase
(
1
)
♦
Carbohydrate Metabolism
(
3
)
♦
FXR
(
12
)
♦
IAP
(
1
)
♦
Lipoxygenase
(
11
)
♦
Mitochondrial Metabolism
(
3
)
♦
PCSK9
(
4
)
♦
Phosphorylase
(
2
)
♦
Serine hydrolase
(
1
)
♦
SGK
(
2
)
♦
SCD
(
1
)
♦
Vitamin
(
15
)
♦
Acyltransferase
(
2
)
♦
CAR
(
2
)
♦
ROR
(
6
)
♦
PRMT
(
2
)
♦
PGC-1α
(
2
)
♦
Lipase
(
3
)
♦
OXPHOS
(
3
)
♦
Peroxidases
(
3
)
♦
Phosphatase
(
6
)
♦
Decarboxylase
(
4
)
♦
Prostaglandin Receptor
(
1
)
♦
Serine/threonin kinase
(
6
)
♦
Fatty Acid Synthase
(
6
)
♦
THR
(
4
)
♦
Glutathione
(
1
)
♦
CPT
(
2
)
♦
Acetyl-CoA Carboxylase
(
5
)
♦
AChR
(
2
)
♦
cGAS
(
2
)
♦
CPSase
(
1
)
♦
AdipoR
(
2
)
♦
GLUT
(
2
)
♦
PKM
(
3
)
♦
Mitochondrial pyruvate carrier
(
1
)
♦
ACSS2
(
1
)
♦
FABP
(
1
)
♦
Xanthine Oxidase
(
1
)
♦
Thrombopoietin Receptor
(
1
)
♦
Thioredoxin Reductase
(
1
)
♦
SHIP
(
1
)
Neuronal Signaling
♦
5-HT Receptor
(
5
)
♦
COX
(
42
)
♦
GluR
(
24
)
♦
Adrenergic Receptor
(
11
)
♦
AChR Receptor
(
63
)
♦
Histamine Receptor
(
8
)
♦
Dopamine Receptor
(
9
)
♦
Opioid Receptor
(
5
)
♦
GABA Receptor
(
19
)
♦
P-gp
(
0
)
♦
CaMK
(
12
)
♦
P2 Receptor
(
9
)
♦
OX Receptor
(
1
)
♦
MT Receptor
(
0
)
♦
BACE
(
3
)
♦
Gamma-secretase
(
0
)
♦
Beta Amyloid
(
19
)
♦
Monoamine Oxidase
(
13
)
♦
P2Y Receptor
(
1
)
♦
NMDAR
(
7
)
♦
γ-secretase
(
3
)
♦
Calcium Channel
(
6
)
♦
Serotonin Transporter
(
7
)
♦
Transthyretin (TTR)
(
2
)
♦
Notch
(
8
)
♦
ChE
(
10
)
♦
BChE
(
2
)
♦
Glucosylceramide Synthase
(
3
)
♦
AAK1
(
2
)
♦
Dopamine Transporter
(
4
)
♦
Sigma Receptor
(
15
)
♦
Tau Protein
(
1
)
♦
Beta-secretase
(
6
)
♦
Imidazoline Receptor
(
4
)
♦
Adenosine Kinase
(
2
)
♦
α-synuclein
(
1
)
Ubiquitin
♦
E2 conjugating
(
2
)
♦
p97
(
5
)
♦
E3 Ligase
(
11
)
♦
DUB
(
20
)
♦
Proteasome
(
0
)
♦
E1 Activating
(
5
)
♦
SUMO
(
1
)
Stem Cells/Wnt
♦
Hedgehog/Smoothened ROCK
(
5
)
♦
ROCK
(
0
)
♦
Wnt/beta-catenin
(
30
)
♦
Gamma-secretase
(
0
)
♦
Casein Kinase
(
4
)
♦
TGF–beta/Smad
(
1
)
♦
STAT
(
9
)
♦
JAK
(
0
)
♦
GSK-3
(
2
)
♦
Smo
(
5
)
♦
PKA
(
6
)
♦
Oct
(
3
)
♦
Porcupine
(
3
)
♦
Hippo (MST)
(
2
)
♦
YAP
(
5
)
♦
SFRP
(
1
)
♦
Stemness kinase
(
1
)
DNA Damage
♦
Telomerase
(
3
)
♦
Topoisomerase
(
54
)
♦
DNA/RNA Synthesis
(
115
)
♦
HDAC
(
52
)
♦
ATM/ATR
(
18
)
♦
PARP
(
51
)
♦
Sirtuin
(
7
)
♦
DNA Stain
(
4
)
♦
Nucleoside Antimetabolite/Analog
(
7
)
♦
DNA alkylator
(
10
)
♦
p97
(
3
)
♦
CRISPR/Cas9
(
1
)
♦
SMN
(
1
)
♦
HSP
(
11
)
♦
RNR
(
2
)
♦
OGG1
(
2
)
♦
RAD51
(
4
)
♦
PARG
(
1
)
GPCR & G Protein
♦
cAMP
(
8
)
♦
Adenosine Receptor
(
38
)
♦
Vasopressin Receptor
(
8
)
♦
CXCR
(
35
)
♦
CaSR
(
8
)
♦
PAFR
(
2
)
♦
CGRP Receptor
(
6
)
♦
LPA Receptor
(
2
)
♦
SGLT
(
8
)
♦
S1P Receptor
(
12
)
♦
Endothelin Receptor
(
13
)
♦
Cannabinoid Receptor
(
24
)
♦
5-HT Receptor
(
140
)
♦
Adrenergic Receptor
(
113
)
♦
Histamine Receptor
(
76
)
♦
Dopamine Receptor
(
77
)
♦
Opioid Receptor
(
29
)
♦
Hedgehog/Smoothened ROCK
(
11
)
♦
OX Receptor
(
23
)
♦
MT Receptor
(
2
)
♦
Guanylate Cyclase
(
15
)
♦
LPL Receptor
(
18
)
♦
NPY receptor
(
1
)
♦
Angiotensin Receptor
(
21
)
♦
Free Fatty Acid Receptor
(
10
)
♦
GnRH Receptor
(
10
)
♦
GPR
(
21
)
♦
Leukotriene Receptor
(
8
)
♦
mAChR
(
32
)
♦
Neurotensin Receptor
(
4
)
♦
Prostaglandin Receptor
(
40
)
♦
Sigma Receptor
(
1
)
♦
PAR
(
10
)
♦
CCR
(
21
)
♦
GCGR
(
27
)
♦
GHSR
(
6
)
♦
GPCR19
(
3
)
♦
LTR
(
1
)
♦
mGluR
(
29
)
♦
PKD
(
2
)
♦
Ras
(
22
)
♦
CCK receptor
(
4
)
♦
Melatonin Receptor
(
5
)
♦
Formyl Peptide Receptor
(
2
)
♦
G protein-coupled Bile Acid Receptor
(
2
)
♦
Melanocortin Receptor
(
5
)
♦
Neurokinin Receptor
(
12
)
♦
Oxytocin Receptor
(
3
)
♦
Somatostatin Receptor
(
3
)
♦
Adenylate Cyclase
(
3
)
♦
Bradykinin Receptor
(
3
)
♦
P2Y Receptor
(
7
)
♦
Urotensin Receptor
(
1
)
♦
TSH Receptor
(
2
)
♦
PKG
(
2
)
♦
RGS Protein
(
3
)
♦
Glucagon Receptor
(
2
)
♦
TAAR
(
1
)
♦
Neuropeptide Y Receptor
(
5
)
♦
Motilin Receptor
(
1
)
♦
CRFR
(
3
)
♦
APJ
(
1
)
♦
EBI2
(
1
)
♦
Bombesin Receptor
(
2
)
♦
GPR109A
(
2
)
♦
MRGPR
(
2
)
TGF-beta/Smad
♦
MT Receptor
(
20
)
♦
Bcr-Abl
(
0
)
♦
ROCK
(
23
)
♦
PKC
(
16
)
♦
TGF-β Receptor
(
13
)
♦
TGF-beta/Smad
(
6
)
Cell Cycle
♦
CDK
(
105
)
♦
Rho
(
19
)
♦
PLK
(
19
)
♦
Chk
(
12
)
♦
Aurora Kinase
(
7
)
♦
ROCK
(
8
)
♦
PD-1/PD-L1
(
0
)
♦
c-Myc
(
6
)
♦
Wee1
(
2
)
♦
APC
(
3
)
♦
HSP
(
6
)
♦
Microtubule/Tubulin
(
39
)
♦
HDAC
(
18
)
♦
PPAR
(
24
)
♦
Eukaryotic Initiation Factor
(
5
)
♦
Topoisomerase
(
13
)
♦
Ras
(
5
)
♦
Mps1
(
5
)
♦
Kinesin
(
8
)
♦
PAK
(
5
)
♦
PERK
(
1
)
♦
Antifolate
(
3
)
♦
TOPK
(
5
)
♦
PARP
(
0
)
♦
LIMK
(
5
)
♦
G-quadruplex
(
2
)
♦
PFKFB
(
4
)
♦
BMI-1
(
2
)
♦
Mad2
(
1
)
♦
Nur77
(
2
)
♦
p21
(
1
)
♦
SRPK
(
2
)
Cytoskeletal Signaling
♦
Bcr-Abl
(
1
)
♦
Wnt/beta-catenin
(
10
)
♦
PKC
(
0
)
♦
FAK
(
0
)
♦
HSP
(
3
)
♦
Dynamin
(
3
)
♦
PAK
(
4
)
♦
Integrin
(
28
)
♦
Microtubule Associated
(
26
)
♦
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(
6
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MLCK
(
2
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♦
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5
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Myosin
(
3
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(
1
)
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(
1
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TACC3
(
1
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11
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18
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38
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64
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75
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82
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14
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2
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0
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9
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0
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2
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4
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Apical Sodium-Dependent Bile Acid Transporter
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3
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6
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3
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2
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TRP Channel
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42
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3
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♦
CD markers
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4
)
♦
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(
3
)
♦
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(
37
)
♦
Interleukins
(
1
)
♦
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(
20
)
♦
OAT
(
1
)
♦
SGLT
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9
)
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Monocarboxylate Transporter
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2
)
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Adrenergic Receptor
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1
)
♦
P2X Receptor
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9
)
♦
CRAC Channel
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3
)
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6
)
♦
Piezo Channel
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2
)
♦
Aquaporin
(
2
)
♦
EAAT
(
2
)
♦
NKCC
(
1
)
♦
VDAC
(
4
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♦
NHE
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3
)
♦
URAT1
(
4
)
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Na+/K+ ATPase
(
2
)
♦
Na+/Ca2+ Exchanger
(
2
)
♦
ATP Synthase
(
1
)
♦
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1
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MTP
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2
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1
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0
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7
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49
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23
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27
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6
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9
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2
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2
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3
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3
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1
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0
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2
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2
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35
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1
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1
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0
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PKA
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0
)
♦
Thrombin
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0
)
♦
Liver X receptor
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0
)
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IL Receptor
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0
)
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57
)
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86
)
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17
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156
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47
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2381
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6627
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3584
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21
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New5
(
4520
)
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New6
(
3591
)
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New7
(
3409
)
♦
New8
(
4590
)
♦
New9
(
3614
)
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New10
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1380
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3393
)
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New12
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2495
)
Immunology/Inflammation
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STING
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22
)
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16
)
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Arginase
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3
)
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TLR
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31
)
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IRAK
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9
)
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Reactive Oxygen Species
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33
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ROS
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7
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36
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2
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1
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4
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2
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1
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2
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1
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6
)
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11
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7
)
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8
)
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3
)
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Immunology & Inflammation related
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13
)
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1
)
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10
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1
)
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9
)
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TBK1
(
2
)
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1
)
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(
1
)
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LTR
(
2
)
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AP-1
(
2
)
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NLR
(
4
)
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FLAP
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5
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5
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5
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1
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1
)
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1
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16
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7
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10
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44
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5
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111
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15
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3
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21
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6
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32
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5
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16
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4
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14
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16
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5
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2
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12
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2
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5
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6
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5
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5
)
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1
)
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6
)
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5
)
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28
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8
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1
)
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4
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3
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6
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7
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5
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12
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1
)
♦
FTO
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2
)
♦
DHODH
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1
)
♦
HMGCR
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5
)
♦
FASN
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9
)
♦
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2
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8
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6
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11
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1
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6
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5
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5
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2
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3
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1
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2
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3
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1
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2
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4
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3
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2
)
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1
)
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2
)
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1
)
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5
)
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3
)
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PREP
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2
)
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8
)
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IDH
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5
)
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1
)
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4
)
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ATGL
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1
)
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(
3
)
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1
)
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1
)
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1
)
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1
)
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1
)
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1
)
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1
)
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1
)
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8
)
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44
)
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34
)
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270
)
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16
)
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5
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29
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1
)
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44
)
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16
)
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4
)
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3
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19
)
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2
)
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3
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1
)
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1
)
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6
)
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26
)
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3
)
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8
)
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(
1
)
♦
ERR
(
30
)
♦
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(
6
)
♦
Androgen Receptor
(
14
)
♦
VD/VDR
(
19
)
PROTAC
♦
PROTAC Linkers
(
44
)
♦
E3 Ligase Ligand-Linker Conjugates
(
8
)
♦
Ligands for E3 Ligase
(
11
)
♦
Ligands for Target Protein for PROTAC
(
2
)
♦
ATTECs
(
1
)
♦
Molecular Glues
(
2
)
Unfolded Protein Response
♦
Deubiquitinase
(
4
)
♦
IRE1
(
8
)
♦
PDI
(
1
)
♦
Eukaryotic Initiation Factor
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2
)
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♦
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1
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63
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50
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3
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1
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1
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1
)
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Natural Products 1
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419
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1984
)
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384
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Bulletin Board
Phosphoramidon disodium salt
Catalog No：
V1913
CAS No. (CAS Registry Number)：
164204-38-0
Price：
$0/g
Description: Phosphoramidon disodium salt is a potent metalloendopeptidase inhibitor, which is widely used as a biochemical research tool. Phosphoramidon In porcine aortic endothelial cells, phos...
Edaravone (MCI-186)
Catalog No：
V2065
CAS No. (CAS Registry Number)：
89-25-8
Price：
$0/g
Description: Edaravone (formerly known as Radicut; MCI-186; NCI-C03952; NSC 12; Norantipyrine; Norphenazone; trade name: Radicava) is a novel and potent free radical scavenger that has ...
GW280264X
Catalog No：
V2172
CAS No. (CAS Registry Number)：
866924-39-2
Price：
$0/g
Description: GW280264X is a novel and potent ADAM17 inhibitor.
FT 011
Catalog No：
V2835
CAS No. (CAS Registry Number)：
1001288-58-9
Price：
$0/g
Description: FT011 is a novel potent anti-inflammatory and anti-fibrotic agent that has been reported to attenuate organ damage in diabetic rats with cardiomyopathy and nephropathy. n diabet...
CTS-1027
Catalog No：
V3665
CAS No. (CAS Registry Number)：
193022-04-7
Price：
$0/g
Description: CTS-1027 is a novel, potent small molecule inhibitor of MMPs (matrix metalloproteinase) with IC50s of 0.3 nM, 0.5 nM for MMP2, MMP13, respectively, and has ...
GI254023X
Catalog No：
V4081
CAS No. (CAS Registry Number)：
260264-93-5
Price：
$0/g
Description: GI254023X(also known as GI4023 and SRI028594) is a novel and potent inhibitor ofMMP9 (Matrix Metallopeptidase 9) and ADAM10 (A Disintegrin and Metalloproteinase 10) with...
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