Immunology/Inflammation

location： Home > Products > Signaling Pathways > Immunology/Inflammation

Signaling Pathways
Apoptosis
- ♦ Bcl-2(19)
- ♦ p53(12)
- ♦ Caspase(17)
- ♦ TNFa(16)
- ♦ Mdm2(17)
- ♦ c-RET(4)
- ♦ IAP(7)
- ♦ PERK(4)
- ♦ PD-1/PD-L1(15)
- ♦ Survivin(1)
- ♦ Apoptosis(27)
- ♦ RIP kinase(7)
- ♦ ROS(1)
- ♦ Cytohesin(1)
- ♦ Ras(1)
- ♦ Thymidylate Synthase(3)
- ♦ DAPK(1)
- ♦ Ferroptosis(1)
- ♦ ASK(1)
- ♦ FKBP(1)
- ♦ Ferroptosis(1)
PI3K/Akt/mTOR
- ♦ PI3K (72)
- ♦ Akt (26)
- ♦ mTOR (25)
- ♦ GSK-3 (18)
- ♦ ATM/ATR (0)
- ♦ PDK-1 (4)
- ♦ S6 kinase (6)
- ♦ AMPK (14)
- ♦ DNA-PK (5)
- ♦ PTEN(1)
- ♦ PDPK1(1)
- ♦ NUDIX(1)
- ♦ PDHK(1)
- ♦ PI4K(1)
- ♦ PP2A(1)
Epigenetics
- ♦ HDAC(6)
- ♦ HIF(7)
- ♦ PARP(0)
- ♦ JAK(40)
- ♦ Aurora Kinase(23)
- ♦ Histone Acetyltransferase (9)
- ♦ Histone Demethylase(15)
- ♦ Histone Methyltransferase (46)
- ♦ DNA Methyltransferase(9)
- ♦ Epigenetic Reader Domain (30)
- ♦ Sirtuin (13)
- ♦ Pim (6)
- ♦ PKC(8)
- ♦ SMYD(1)
- ♦ Methionine Adenosyltransferase(1)
- ♦ MicroRNA(2)
- ♦ AMPK(1)
- ♦ Protein Arginine Deiminase(2)
MAPK
- ♦ MEK(19)
- ♦ ERK(16)
- ♦ Raf(18)
- ♦ JNK(15)
- ♦ p38 MAPK(20)
- ♦ RSK(3)
- ♦ Mixed Lineage Kinase(1)
- ♦ KLF(1)
- ♦ MNK(2)
Protein Tyrosine Kinase
- ♦ VEGFR (58)
- ♦ EGFR (49)
- ♦ PDGFR(17)
- ♦ c-MET (19)
- ♦ HER-2(2)
- ♦ ALK(16)
- ♦ FLT3 (11)
- ♦ FGFR (15)
- ♦ IFG-1R(10)
- ♦ c-Kit(6)
- ♦ Tie-2(1)
- ♦ CSF-1R(3)
- ♦ TAM Receptor (7)
- ♦ Trk receptor(4)
- ♦ c-RET(0)
- ♦ Axl(1)
- ♦ Bcr-Abl(4)
- ♦ Ephrin Receptor(1)
- ♦ Pyk2(1)
- ♦ c-Fms(4)
- ♦ DDR(1)
- ♦ FLT3(0)
- ♦ HER2(1)
- ♦ Src(2)
- ♦ Syk(1)
- ♦ DYRK(3)
- ♦ FAK(1)
Angiogenesis
- ♦ VEGFR (1)
- ♦ EGFR (1)
- ♦ PDGFR (0)
- ♦ HIF (3)
- ♦ HER-2 (0)
- ♦ JAK (0)
- ♦ FLT3 (0)
- ♦ FGFR (0)
- ♦ BTK (10)
- ♦ Syk(6)
- ♦ FAK (8)
- ♦ Src (8)
- ♦ Bcr-Abl (10)
- ♦ VDA (3)
- ♦ ALK(1)
Proteases
- ♦ Proteasome (13)
- ♦ Cysteine Protease (12)
- ♦ Serine Protease(6)
- ♦ Gamma-secretase (10)
- ♦ HCV Protease (5)
- ♦ HIV Protease(7)
- ♦ MMP (7)
- ♦ DPP-4 (9)
- ♦ Caspase (0)
- ♦ Acyltransferase(1)
- ♦ Tyrosinase(1)
- ♦ Glutaminase(2)
- ♦ Thrombin(3)
- ♦ 3C-Like Protease(1)
NF-kB
- ♦ NOD1 (2)
- ♦ IκB/IKK(20)
- ♦ NF-κB(37)
- ♦ HDAC (0)
- ♦ ROS(1)
Autophagy
- ♦ Autophagy (34)
- ♦ LRRK2 (6)
- ♦ ULK(2)
- ♦ Mitophagy(1)
JAK/STAT
- ♦ JAK (2)
- ♦ STAT(5)
- ♦ EGFR (11)
- ♦ Pim (4)
Metabolism
- ♦ PDE (28)
- ♦ P450 (e.g. CYP) (27)
- ♦ PPAR (18)
- ♦ Phospholipase (8)
- ♦ DHFR(6)
- ♦ Dehydrogenase (24)
- ♦ HSP (20)
- ♦ Carbonic Anhydrase (16)
- ♦ MAO (2)
- ♦ FAAH (6)
- ♦ CETP(4)
- ♦ Transferase (10)
- ♦ HMG-CoA Reductase(11)
- ♦ Hydroxylase (8)
- ♦ IDO (7)
- ♦ Retinoid Receptor (8)
- ♦ Factor Xa (5)
- ♦ AhR (3)
- ♦ Ferroptosis(3)
- ♦ Casein Kinase (7)
- ♦ NAMPT (3)
- ♦ Glucosylceramide Synthase(2)
- ♦ Aldose Reductase(1)
- ♦ ATP-citrate lyase(1)
- ♦ Carbohydrate Metabolism(1)
- ♦ FXR(5)
- ♦ IAP(1)
- ♦ Lipoxygenase(5)
- ♦ Mitochondrial Metabolism(1)
- ♦ PCSK9(2)
- ♦ Phosphorylase(1)
- ♦ Serine hydrolase(1)
- ♦ SGK(1)
- ♦ SCD(1)
- ♦ Vitamin(9)
- ♦ Acyltransferase(2)
- ♦ CAR(2)
- ♦ ROR(3)
- ♦ PRMT(1)
- ♦ PGC-1α(1)
- ♦ Lipase(1)
- ♦ OXPHOS(2)
- ♦ Peroxidases(2)
- ♦ Phosphatase(2)
- ♦ Decarboxylase(3)
- ♦ Prostaglandin Receptor(1)
- ♦ Serine/threonin kinase(2)
- ♦ Fatty Acid Synthase(3)
- ♦ THR(2)
- ♦ Glutathione(1)
- ♦ CPT(1)
- ♦ Acetyl-CoA Carboxylase(1)
- ♦ AChR(1)
- ♦ cGAS(1)
Neuronal Signaling
- ♦ 5-HT Receptor (3)
- ♦ COX (41)
- ♦ GluR (20)
- ♦ Adrenergic Receptor(11)
- ♦ AChR Receptor (62)
- ♦ Histamine Receptor (4)
- ♦ Dopamine Receptor (8)
- ♦ Opioid Receptor (3)
- ♦ GABA Receptor (14)
- ♦ P-gp (0)
- ♦ CaMK (10)
- ♦ P2 Receptor (8)
- ♦ OX Receptor (1)
- ♦ MT Receptor (0)
- ♦ BACE (2)
- ♦ Gamma-secretase (0)
- ♦ Beta Amyloid (13)
- ♦ Monoamine Oxidase(5)
- ♦ P2Y Receptor(1)
- ♦ NMDAR(3)
- ♦ γ-secretase(1)
- ♦ Calcium Channel(3)
- ♦ Serotonin Transporter(4)
- ♦ Transthyretin (TTR)(1)
- ♦ Notch(4)
- ♦ ChE(6)
- ♦ BChE(1)
- ♦ Glucosylceramide Synthase(1)
- ♦ AAK1(1)
- ♦ Dopamine Transporter(2)
- ♦ Sigma Receptor(2)
- ♦ Tau Protein(1)
Ubiquitin
- ♦ E2 conjugating (2)
- ♦ p97 (3)
- ♦ E3 Ligase (2)
- ♦ DUB (13)
- ♦ Proteasome (0)
- ♦ E1 Activating(2)
Stem Cells/Wnt
- ♦ Hedgehog/Smoothened ROCK (2)
- ♦ ROCK(0)
- ♦ Wnt/beta-catenin (13)
- ♦ Gamma-secretase (0)
- ♦ Casein Kinase (3)
- ♦ TGF–beta/Smad (1)
- ♦ STAT (9)
- ♦ JAK (0)
- ♦ GSK-3 (1)
- ♦ Smo(2)
- ♦ PKA(1)
- ♦ Oct(2)
- ♦ Porcupine(1)
- ♦ Hippo (MST)(1)
DNA Damage
- ♦ Telomerase(3)
- ♦ Topoisomerase (47)
- ♦ DNA/RNA Synthesis (84)
- ♦ HDAC (41)
- ♦ ATM/ATR (14)
- ♦ PARP (34)
- ♦ Sirtuin (1)
- ♦ DNA Stain(3)
- ♦ Nucleoside Antimetabolite/Analog(2)
- ♦ DNA alkylator(4)
- ♦ p97(1)
- ♦ CRISPR/Cas9(1)
- ♦ SMN(1)
- ♦ HSP(3)
- ♦ RNR(2)
- ♦ OGG1(1)
- ♦ RAD51(1)
GPCR & G Protein
- ♦ cAMP (3)
- ♦ Adenosine Receptor (24)
- ♦ Vasopressin Receptor (7)
- ♦ CXCR (13)
- ♦ CaSR (4)
- ♦ PAFR (2)
- ♦ CGRP Receptor (1)
- ♦ LPA Receptor (2)
- ♦ SGLT (6)
- ♦ S1P Receptor (11)
- ♦ Endothelin Receptor (10)
- ♦ Cannabinoid Receptor (13)
- ♦ 5-HT Receptor (101)
- ♦ Adrenergic Receptor (83)
- ♦ Histamine Receptor (57)
- ♦ Dopamine Receptor (59)
- ♦ Opioid Receptor (17)
- ♦ Hedgehog/Smoothened ROCK (11)
- ♦ OX Receptor (8)
- ♦ MT Receptor (2)
- ♦ Guanylate Cyclase(6)
- ♦ LPL Receptor(10)
- ♦ NPY receptor(1)
- ♦ Angiotensin Receptor(10)
- ♦ Free Fatty Acid Receptor(4)
- ♦ GnRH Receptor(4)
- ♦ GPR(14)
- ♦ Leukotriene Receptor(2)
- ♦ mAChR(16)
- ♦ Neurotensin Receptor(1)
- ♦ Prostaglandin Receptor(11)
- ♦ Sigma Receptor(1)
- ♦ PAR(4)
- ♦ CCR(2)
- ♦ GCGR(8)
- ♦ GHSR(2)
- ♦ GPCR19(2)
- ♦ LTR(1)
- ♦ mGluR(10)
- ♦ PKD(1)
- ♦ Ras(4)
- ♦ CCK receptor(4)
- ♦ Melatonin Receptor(2)
- ♦ Formyl Peptide Receptor(1)
- ♦ G protein-coupled Bile Acid Receptor(1)
- ♦ Melanocortin Receptor(3)
- ♦ Neurokinin Receptor(2)
- ♦ Oxytocin Receptor(1)
- ♦ Somatostatin Receptor(2)
- ♦ Adenylate Cyclase(2)
- ♦ Bradykinin Receptor(2)
- ♦ P2Y Receptor(1)
- ♦ Urotensin Receptor(1)
- ♦ TSH Receptor(1)
- ♦ PKG(1)
TGF-beta/Smad
- ♦ MT Receptor (20)
- ♦ Bcr-Abl (0)
- ♦ ROCK (20)
- ♦ PKC (11)
- ♦ TGF-β Receptor(7)
Cell Cycle
- ♦ CDK (55)
- ♦ Rho (17)
- ♦ PLK (14)
- ♦ Chk (8)
- ♦ Aurora Kinase (0)
- ♦ ROCK (4)
- ♦ PD-1/PD-L1 (0)
- ♦ c-Myc (4)
- ♦ Wee1 (1)
- ♦ APC (2)
- ♦ HSP(3)
- ♦ Microtubule/Tubulin(22)
- ♦ HDAC(5)
- ♦ PPAR(8)
- ♦ Eukaryotic Initiation Factor(1)
- ♦ Topoisomerase(4)
- ♦ Ras(2)
- ♦ Mps1(1)
- ♦ Kinesin(3)
- ♦ PAK(3)
- ♦ PERK(1)
- ♦ Antifolate(2)
- ♦ TOPK(1)
- ♦ PARP(1)
- ♦ LIMK(1)
- ♦ G-quadruplex(1)
Cytoskeletal Signaling
- ♦ Bcr-Abl(1)
- ♦ Wnt/beta-catenin (10)
- ♦ PKC (0)
- ♦ FAK(0)
- ♦ HSP (1)
- ♦ Dynamin (3)
- ♦ PAK (4)
- ♦ Integrin (16)
- ♦ Microtubule Associated(25)
- ♦ Kinesin (6)
- ♦ MLCK(1)
- ♦ Gap Junction Protein(3)
- ♦ Myosin(2)
Transmembrane
- ♦ P-gp (9)
- ♦ Proton Pump (16)
- ♦ GABA Receptor (23)
- ♦ Sodium Channel (43)
- ♦ Potassium Channel (40)
- ♦ Calcium Channel (56)
- ♦ ATPase (10)
- ♦ CRM1 (2)
- ♦ TRPV (0)
- ♦ CFTR (2)
- ♦ OCT (0)
- ♦ Amino Acid Transporter(1)
- ♦ Monocarboxylate Transporter(0)
- ♦ Apical Sodium-Dependent Bile Acid Transporter(1)
- ♦ Chloride Channel(3)
- ♦ GlyT(2)
- ♦ P2 Receptor(2)
- ♦ TRP Channel(19)
- ♦ BCRP(2)
- ♦ CD markers(2)
- ♦ HCN Channel(3)
- ♦ iGluR(12)
- ♦ Interleukins(1)
- ♦ nAChR(6)
- ♦ OAT(1)
- ♦ SGLT(2)
- ♦ Monocarboxylate Transporter(1)
- ♦ Adrenergic Receptor(1)
- ♦ P2X Receptor(1)
- ♦ CRAC Channel(2)
- ♦ Monoamine Transporter(2)
- ♦ Piezo Channel(1)
- ♦ Aquaporin(1)
- ♦ EAAT(1)
Endocrinology & Hormones
- ♦ Opioid Receptor (0)
- ♦ Glucocorticoid Receptor(8)
- ♦ Estrogen/progestogen Receptor (47)
- ♦ Androgen Receptor (18)
- ♦ RAAS (27)
- ♦ Aromatase(6)
- ♦ GPR(8)
- ♦ 5-alpha Reductase (2)
- ♦ Adrenergic Receptor(1)
- ♦ Mineralocorticoid Receptor(2)
- ♦ ACE(3)
- ♦ TSH Receptor(2)
- ♦ THR(1)
Microbiology
- ♦ HCV Protease (1)
- ♦ HIV Protease (2)
- ♦ CCR (2)
- ♦ Reverse Transcriptase(31)
- ♦ Integrase (0)
- ♦ Bacterial(12)
- ♦ Anti-infection(4)
- ♦ HSV(1)
- ♦ Influenza Virus(1)
- ♦ RSV(1)
- ♦ β-lactamase(1)
- ♦ Antibiotics(3)
- ♦ Antiviral(3)
- ♦ Parasite(6)
- ♦ Fungal(7)
- ♦ CMV(3)
- ♦ COVID-19(2)
Others
- ♦ IL Receptor (0)
- ♦ Biochemical Assay Reagents(12)
- ♦ Fluorescent Dye(30)
- ♦ Amino Acid Derivatives(1)
- ♦ gp120/CD4 (2)
- ♦ FXR(4)
- ♦ PKA (2)
- ♦ Thrombin (4)
- ♦ Liver X receptor (3)
- ♦ Others 1(364)
- ♦ Others 2(432)
- ♦ Others 3(332)
- ♦ Others 4(295)
- ♦ Others 5(250)
- ♦ Others 6(572)
- ♦ Others 7(235)
New Products
- ♦ New1(23635)
- ♦ New2(7157)
- ♦ New3(9979)
- ♦ New4(21)
Immunology/Inflammation
- ♦ STING(12)
- ♦ Glucocorticoid Receptor(7)
- ♦ Arginase(3)
- ♦ TLR(9)
- ♦ IRAK(4)
- ♦ Reactive Oxygen Species(13)
- ♦ ROS(4)
- ♦ COX(16)
- ♦ Prostaglandin Receptor(2)
- ♦ MIF(1)
- ♦ Nrf2(3)
- ♦ AKR1C(2)
- ♦ Antibiotics(1)
- ♦ Galectin(2)
- ♦ IFN(1)
- ♦ SPHK(4)
- ♦ Interleukins(4)
- ♦ NO Synthase(4)
- ♦ PGE synthase(4)
- ♦ SIK(1)
- ♦ Immunology & Inflammation related(8)
- ♦ PKR(1)
- ♦ PD-1/PD-L1(2)
- ♦ NLRP3(1)
- ♦ Complement System(2)
ADC Related
- ♦ ADC Linker(7)
- ♦ ADC Cytotoxin(4)
- ♦ Drug-Linker Conjugates for ADC(5)
Metabolic Enzyme/Protease
- ♦ Phosphodiesterase(PDE)(19)
- ♦ Aminopeptidase(2)
- ♦ Endogenous Metabolite(48)
- ♦ Phospholipase(5)
- ♦ ALDH(1)
- ♦ Cytochrome P450(9)
- ♦ Dipeptidyl Peptidase(2)
- ♦ Drug Metabolite(14)
- ♦ Farnesyl Transferase(2)
- ♦ HIF/HIF Prolyl-Hydroxylase(3)
- ♦ Lactate Dehydrogenase(2)
- ♦ Mitochondrial Metabolism(2)
- ♦ MMP(3)
- ♦ PAI-1(1)
- ♦ PDI(2)
- ♦ RAR/RXR(6)
- ♦ REV-ERB(1)
- ♦ ROR(2)
- ♦ Thrombin(3)
- ♦ 11β-HSD(2)
- ♦ MAGL(2)
- ♦ TrxR(1)
- ♦ Tyrosinase(3)
- ♦ Glucokinase(3)
- ♦ Phosphatase(5)
- ♦ Aldose Reductase(4)
- ♦ Carbonic Anhydrase(1)
- ♦ Epoxide Hydrolase(2)
- ♦ Mineralocorticoid Receptor(1)
- ♦ SCD(1)
- ♦ ACE(4)
- ♦ FXR(2)
- ♦ LXR(1)
- ♦ DGK(1)
- ♦ FTO(1)
- ♦ DHODH(1)
- ♦ HMGCR(1)
- ♦ FASN(4)
- ♦ Renin(2)
- ♦ Liposome(4)
- ♦ NADPH Oxidase(2)
- ♦ Glucosidase(4)
- ♦ HIV Protease(1)
- ♦ Factor Xa(1)
- ♦ Acyltransferase(1)
- ♦ Glutathione Peroxidase(1)
- ♦ Gutathione S-transferase(0)
- ♦ 5 alpha Reductase(1)
- ♦ Tryptophan Hydroxylase(1)
- ♦ Procollagen C Proteinase(1)
- ♦ Dopamine β-hydroxylase(1)
- ♦ NEDD8-activating Enzyme(1)
- ♦ Reactive Oxygen Species(1)
Anti-infection
- ♦ HSV(3)
- ♦ Fungal(20)
- ♦ Influenza Virus(17)
- ♦ Bacterial(117)
- ♦ HBV(6)
- ♦ HCV Protease(7)
- ♦ HIV(12)
- ♦ RABV(1)
- ♦ Parasite(12)
- ♦ Antibiotic(7)
- ♦ Reverse Transcriptase(2)
- ♦ Virus Protease(1)
- ♦ SARS-CoV(5)
- ♦ RSV(1)
Vitamin D Related/Nuclear Receptor
- ♦ Progesterone Receptor(7)
- ♦ Glucocorticoid Receptor(1)
- ♦ ERR(15)
- ♦ Thyroid Hormone Receptor(5)
- ♦ Androgen Receptor(3)
- ♦ VD/VDR(8)
PROTAC
- ♦ PROTAC Linkers(40)
- ♦ E3 Ligase Ligand-Linker Conjugates(8)
Unfolded Protein Response
- ♦ Deubiquitinase(1)
- ♦ IRE1(2)
- ♦ PDI(1)
- ♦ Eukaryotic Initiation Factor(1)

Product Type
Natural Products
- ♦ Natural Products 1(443)
Peptides
- ♦ Peptides 1(1969)
Antibodies
Amino Acids
- ♦ Amino Acids 1(384)
PROTACs
- ♦ PROTACs 1(33)
Fine Intermediates/Building Blocks
Others

Bulletin Board

SR-717 lithium

Catalog No： V2205

CAS No. (CAS Registry Number)： 2375421-09-1

Price： $0/g

Description: SR-717 lithium is a novel, potent and non-nucleotide STING (stimulator of interferon genes) agonist with anticancer activities. It has EC50 values of 2.1 μM and 2.2 μM in ISG-T...

BEC HCl

Catalog No： V5730

CAS No. (CAS Registry Number)： 222638-67-7

Price： $0/g

Description: BEC HCl is a novel and potent Arginase II inhibitor.

SM-324405

Catalog No： V5846

CAS No. (CAS Registry Number)： 677773-91-0

Price： $0/g

Description: SM-324405 (SM324405; SM 324405) is a novel and potent TLR7 (toll-like receptor 7) agonist designed by introducing the antedrug concept with reduced systemic activity. Toll-like rec...

IRAK-IN-6

Catalog No： V6791

CAS No. (CAS Registry Number)： 1042672-97-8

Price： $0/g

Description: IRAK-IN-6, formerly known as IRAK inhibitor 6, is an interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor. IRAK-4 is reported to be essential for the activation of the intracellu...

Numidargistat 2HCl (CB1158, INCB01158)

Catalog No： V7270

CAS No. (CAS Registry Number)： 2095732-06-0 (free base)

Price： $0/g

Description: Numidargistat 2HCl (CB-1158 B, INCB-01158; INCB001158) is a novel, potent and orally bioavailable immunomodulating agent acting as an arginase inhibitor with IC50s of 86 nM and 296 nM fo...

ATF6-activator-147 (AA147)

Catalog No： V7475

CAS No. (CAS Registry Number)： 393121-74-9

Price： $0/g

Description: AA147 is an ATF6 simulator. It acts as a prodrug that preferentially triggers ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modif...

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