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    Catalog No: V0714
    CAS No. (CAS Registry Number): 208255-80-5
    Description: DAPT (also known as GSI-IX) is a novel, potent and selective γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT has important pharmacologic...
    Catalog No: V0715
    CAS No. (CAS Registry Number): 847925-91-1
    Description: RO4929097 (also known as RO04929097) is a novel, potent and orally bioavailable small molecule inhibitor of the γ-secretase (gamma secretase--GS) with IC50 of 4 nM in a cell-free assay. I...
    Catalog No: V0716
    CAS No. (CAS Registry Number): 425386-60-3
    Description: Semagacestat (also known as LY450139 or LY4501) is a novel and potent γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, it also inhibits Notch signali...
    Catalog No: V0717
    CAS No. (CAS Registry Number): 471905-41-6
    Description: MK0752 is a novel, potent and synthetic small molecule inhibitor of γ-secretase. It reduces Aβ40 production with IC50 of 5 nM and has potential antineoplastic activity. Inhibition of ...
    Catalog No: V0718
    CAS No. (CAS Registry Number): 1146699-66-2
    Description: Avagacestat (formerly known as BMS-708163) is a potent, selective, orally bioactive γ -secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, it demonstrated a 193-fol...
    Catalog No: V0719
    CAS No. (CAS Registry Number): 292632-98-5
    Description: L-685,458 (also known as L685458) is a novel, specific, potent, and selective inhibitor of A ß PP γ-secretase activity with Ki of 17 nM. It shows more than 5...
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