DHFR - InvivoChem

location： Home > Products > Signaling Pathways > Metabolism > DHFR

Signaling Pathways
Apoptosis
- ♦ Bcl-2(11)
- ♦ p53(11)
- ♦ Caspase(10)
- ♦ TNFa(4)
- ♦ Mdm2(14)
- ♦ c-RET(4)
- ♦ IAP(6)
- ♦ PERK(4)
- ♦ PD-1/PD-L1(11)
- ♦ Survivin(1)
PI3K/Akt/mTOR
- ♦ PI3K (61)
- ♦ Akt (18)
- ♦ mTOR (21)
- ♦ GSK-3 (15)
- ♦ ATM/ATR (0)
- ♦ PDK-1 (4)
- ♦ S6 kinase (6)
- ♦ AMPK (8)
- ♦ DNA-PK (3)
Epigenetics
- ♦ HDAC(0)
- ♦ HIF(8)
- ♦ PARP(0)
- ♦ JAK(34)
- ♦ Aurora Kinase(23)
- ♦ Histone Acetyltransferase (5)
- ♦ Histone Demethylase(9)
- ♦ Histone Methyltransferase (26)
- ♦ DNA Methyltransferase(8)
- ♦ Epigenetic Reader Domain (19)
- ♦ Sirtuin (11)
- ♦ Pim (6)
MAPK
- ♦ MEK(18)
- ♦ ERK(8)
- ♦ Raf(15)
- ♦ JNK(7)
- ♦ p38 MAPK(13)
Protein Tyrosine Kinase
- ♦ VEGFR (46)
- ♦ EGFR (39)
- ♦ PDGFR(11)
- ♦ c-MET (14)
- ♦ HER-2(2)
- ♦ ALK(10)
- ♦ FLT3 (8)
- ♦ FGFR (10)
- ♦ IFG-1R(8)
- ♦ c-Kit(3)
- ♦ Tie-2(1)
- ♦ CSF-1R(2)
- ♦ TAM Receptor (6)
- ♦ Trk receptor(3)
- ♦ c-RET(0)
Angiogenesis
- ♦ VEGFR (0)
- ♦ EGFR (0)
- ♦ PDGFR (0)
- ♦ HIF (0)
- ♦ HER-2 (0)
- ♦ JAK (0)
- ♦ FLT3 (0)
- ♦ FGFR (0)
- ♦ BTK (7)
- ♦ Syk(6)
- ♦ FAK (8)
- ♦ Src (8)
- ♦ Bcr-Abl (10)
- ♦ VDA (3)
Proteases
- ♦ Proteasome (13)
- ♦ Cysteine Protease (11)
- ♦ Serine Protease(5)
- ♦ Gamma-secretase (10)
- ♦ HCV Protease (5)
- ♦ HIV Protease(7)
- ♦ MMP (6)
- ♦ DPP-4 (8)
- ♦ Caspase (0)
NF-kB
- ♦ NOD1 (2)
- ♦ IκB/IKK(14)
- ♦ NF-κB(6)
- ♦ HDAC (0)
Autophagy
- ♦ Autophagy (20)
- ♦ LRRK2 (5)
JAK/STAT
- ♦ JAK (0)
- ♦ STAT(0)
- ♦ EGFR (0)
- ♦ Pim (0)
Metabolism
- ♦ PDE (26)
- ♦ P450 (e.g. CYP) (24)
- ♦ PPAR (16)
- ♦ Phospholipase (7)
- ♦ DHFR(5)
- ♦ Dehydrogenase (20)
- ♦ HSP (20)
- ♦ Carbonic Anhydrase (16)
- ♦ MAO (0)
- ♦ FAAH (5)
- ♦ CETP(4)
- ♦ Transferase (8)
- ♦ HMG-CoA Reductase(11)
- ♦ Hydroxylase (8)
- ♦ IDO (4)
- ♦ Retinoid Receptor (5)
- ♦ Factor Xa (4)
- ♦ AhR (3)
- ♦ Ferroptosis(3)
- ♦ Casein Kinase (3)
- ♦ NAMPT (3)
Neuronal Signaling
- ♦ 5-HT Receptor (0)
- ♦ COX (40)
- ♦ GluR (16)
- ♦ Adrenergic Receptor(0)
- ♦ AChR Receptor (47)
- ♦ Histamine Receptor (0)
- ♦ Dopamine Receptor (0)
- ♦ Opioid Receptor (0)
- ♦ GABA Receptor (0)
- ♦ P-gp (0)
- ♦ CaMK (8)
- ♦ P2 Receptor (7)
- ♦ OX Receptor (0)
- ♦ MT Receptor (0)
- ♦ BACE (2)
- ♦ Gamma-secretase (0)
- ♦ Beta Amyloid (1)
Ubiquitin
- ♦ E2 conjugating (1)
- ♦ p97 (3)
- ♦ E3 Ligase (0)
- ♦ DUB (8)
- ♦ Proteasome (0)
Stem Cells/Wnt
- ♦ Hedgehog/Smoothened ROCK (0)
- ♦ ROCK(0)
- ♦ Wnt/beta-catenin (0)
- ♦ Gamma-secretase (0)
- ♦ Casein Kinase (0)
- ♦ TGF–beta/Smad (0)
- ♦ STAT (9)
- ♦ JAK (0)
- ♦ GSK-3 (0)
DNA Damage
- ♦ Telomerase(2)
- ♦ Topoisomerase (36)
- ♦ DNA/RNA Synthesis (65)
- ♦ HDAC (38)
- ♦ ATM/ATR (14)
- ♦ PARP (27)
- ♦ Sirtuin (0)
GPCR & G Protein
- ♦ cAMP (1)
- ♦ Adenosine Receptor (4)
- ♦ Vasopressin Receptor (3)
- ♦ CXCR (3)
- ♦ CaSR (2)
- ♦ PAFR (2)
- ♦ CGRP Receptor (1)
- ♦ LPA Receptor (2)
- ♦ SGLT (4)
- ♦ S1P Receptor (6)
- ♦ Endothelin Receptor (7)
- ♦ Cannabinoid Receptor (7)
- ♦ 5-HT Receptor (63)
- ♦ Adrenergic Receptor (65)
- ♦ Histamine Receptor (41)
- ♦ Dopamine Receptor (28)
- ♦ Opioid Receptor (9)
- ♦ Hedgehog/Smoothened ROCK (11)
- ♦ OX Receptor (7)
- ♦ MT Receptor (2)
TGF-beta/Smad
- ♦ MT Receptor (20)
- ♦ Bcr-Abl (0)
- ♦ ROCK (20)
- ♦ PKC (9)
Cell Cycle
- ♦ CDK (36)
- ♦ Rho (13)
- ♦ PLK (10)
- ♦ Chk (6)
- ♦ Aurora Kinase (0)
- ♦ ROCK (0)
- ♦ PD-1/PD-L1 (0)
- ♦ c-Myc (2)
- ♦ Wee1 (1)
- ♦ APC (1)
Cytoskeletal Signaling
- ♦ Bcr-Abl(1)
- ♦ Wnt/beta-catenin (10)
- ♦ PKC (1)
- ♦ FAK(0)
- ♦ HSP (0)
- ♦ Dynamin (3)
- ♦ PAK (3)
- ♦ Integrin (8)
- ♦ Microtubule Associated(24)
- ♦ Kinesin (6)
Transmembrane
- ♦ P-gp (6)
- ♦ Proton Pump (10)
- ♦ GABA Receptor (11)
- ♦ Sodium Channel (27)
- ♦ Potassium Channel (16)
- ♦ Calcium Channel (29)
- ♦ ATPase (0)
- ♦ CRM1 (1)
- ♦ TRPV (0)
- ♦ CFTR (0)
- ♦ OCT (0)
Endocrinology & Hormones
- ♦ Opioid Receptor (0)
- ♦ Glucocorticoid Receptor(5)
- ♦ Estrogen/progestogen Receptor (34)
- ♦ Androgen Receptor (13)
- ♦ RAAS (27)
- ♦ Aromatase(5)
- ♦ GPR(5)
- ♦ 5-alpha Reductase (2)
Microbiology
- ♦ HCV Protease (0)
- ♦ HIV Protease (0)
- ♦ CCR (1)
- ♦ Reverse Transcriptase(26)
- ♦ Integrase (0)
Others
- ♦ gp120/CD4 (2)
- ♦ FXR(4)
- ♦ PKA (2)
- ♦ Thrombin (4)
- ♦ Liver X receptor (3)
- ♦ IL Receptor (0)
- ♦ Others 1(355)
- ♦ Others 2(434)
- ♦ Others 3(339)
- ♦ Others 4(300)
- ♦ Others 5(249)
- ♦ Others 6(191)
- ♦ Others 7(231)
New Products
- ♦ New1(28819)
- ♦ New2(3408)
- ♦ New3(861)

Product Type
Natural Products
- ♦ Natural Products 1(444)
Peptides
- ♦ Peptides 1(2000)
Antibodies
Amino Acids
- ♦ Amino Acids 1(389)
PROTACs
- ♦ PROTACs 1(42)
Fine Intermediates/Building Blocks
Others

Catalog No： V0847

CAS No. (CAS Registry Number)： 59-05-2

Price： $0/g

Description: Methotrexate (also known as NCI-C04671) is an antimetabolite and antifolate drug, which acts by inhibiting the metabolism of folic acid in activated peripheral T cells. Methotrexate ...

Pralatrexate (racemic)

Catalog No： V0848

CAS No. (CAS Registry Number)： 146464-95-1

Price： $0/g

Description: Pralatrexate (also known as Folotyn), an antifolate which is structurally a folate analog, is a potent inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced fol...

Pyrimethamine

Catalog No： V0849

CAS No. (CAS Registry Number)： 58-14-0

Price： $0/g

Description: Pyrimethamine (Pirimecidan; Pirimetamin; RP 4753) is a potent dihydrofolate reductase (DHFR) inhibitor which is used as an antimalarial and antiprotozoal drug. Py...

Sulfameter

Catalog No： V0850

CAS No. (CAS Registry Number)： 651-06-9

Price： $0/g

Description: Sulfameter (Bayrena; Sulfametoxydiazine; 5-Methoxysulfadiazine) is a long-acting sulfonamide antibacterial agent used as a leprostatic agent and to treat urinary tract infections. Sulfona...

Pemetrexed Disodium Hydrate

Catalog No： V0851

CAS No. (CAS Registry Number)： 357166-30-4

Price： $0/g

Description: Pemetrexed Disodium Hydrate, the disodium salt of a synthetic pyrimidine-based antifolate, is a novel antifolate and antimetabolite anticancer drug for TS, DHFR and GARFT with Ki of 1.3 n...

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