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Carbonic Anhydrase
Signaling Pathways
Apoptosis
♦
Bcl-2
(
11
)
♦
p53
(
11
)
♦
Caspase
(
10
)
♦
TNFa
(
4
)
♦
Mdm2
(
14
)
♦
c-RET
(
4
)
♦
IAP
(
6
)
♦
PERK
(
4
)
♦
PD-1/PD-L1
(
11
)
♦
Survivin
(
1
)
PI3K/Akt/mTOR
♦
PI3K
(
62
)
♦
Akt
(
18
)
♦
mTOR
(
21
)
♦
GSK-3
(
17
)
♦
ATM/ATR
(
0
)
♦
PDK-1
(
4
)
♦
S6 kinase
(
6
)
♦
AMPK
(
8
)
♦
DNA-PK
(
3
)
Epigenetics
♦
HDAC
(
2
)
♦
HIF
(
8
)
♦
PARP
(
0
)
♦
JAK
(
33
)
♦
Aurora Kinase
(
23
)
♦
Histone Acetyltransferase
(
6
)
♦
Histone Demethylase
(
9
)
♦
Histone Methyltransferase
(
26
)
♦
DNA Methyltransferase
(
8
)
♦
Epigenetic Reader Domain
(
19
)
♦
Sirtuin
(
11
)
♦
Pim
(
6
)
MAPK
♦
MEK
(
18
)
♦
ERK
(
8
)
♦
Raf
(
15
)
♦
JNK
(
7
)
♦
p38 MAPK
(
13
)
Protein Tyrosine Kinase
♦
VEGFR
(
46
)
♦
EGFR
(
40
)
♦
PDGFR
(
11
)
♦
c-MET
(
14
)
♦
HER-2
(
2
)
♦
ALK
(
10
)
♦
FLT3
(
8
)
♦
FGFR
(
10
)
♦
IFG-1R
(
8
)
♦
c-Kit
(
3
)
♦
Tie-2
(
1
)
♦
CSF-1R
(
2
)
♦
TAM Receptor
(
6
)
♦
Trk receptor
(
3
)
♦
c-RET
(
0
)
Angiogenesis
♦
VEGFR
(
1
)
♦
EGFR
(
0
)
♦
PDGFR
(
0
)
♦
HIF
(
0
)
♦
HER-2
(
0
)
♦
JAK
(
0
)
♦
FLT3
(
0
)
♦
FGFR
(
0
)
♦
BTK
(
7
)
♦
Syk
(
6
)
♦
FAK
(
8
)
♦
Src
(
8
)
♦
Bcr-Abl
(
10
)
♦
VDA
(
3
)
Proteases
♦
Proteasome
(
13
)
♦
Cysteine Protease
(
11
)
♦
Serine Protease
(
5
)
♦
Gamma-secretase
(
10
)
♦
HCV Protease
(
5
)
♦
HIV Protease
(
7
)
♦
MMP
(
6
)
♦
DPP-4
(
8
)
♦
Caspase
(
0
)
NF-kB
♦
NOD1
(
2
)
♦
IκB/IKK
(
14
)
♦
NF-κB
(
6
)
♦
HDAC
(
0
)
Autophagy
♦
Autophagy
(
20
)
♦
LRRK2
(
5
)
JAK/STAT
♦
JAK
(
1
)
♦
STAT
(
0
)
♦
EGFR
(
0
)
♦
Pim
(
0
)
Metabolism
♦
PDE
(
26
)
♦
P450 (e.g. CYP)
(
24
)
♦
PPAR
(
16
)
♦
Phospholipase
(
7
)
♦
DHFR
(
5
)
♦
Dehydrogenase
(
19
)
♦
HSP
(
20
)
♦
Carbonic Anhydrase
(
16
)
♦
MAO
(
0
)
♦
FAAH
(
5
)
♦
CETP
(
4
)
♦
Transferase
(
8
)
♦
HMG-CoA Reductase
(
11
)
♦
Hydroxylase
(
8
)
♦
IDO
(
4
)
♦
Retinoid Receptor
(
5
)
♦
Factor Xa
(
4
)
♦
AhR
(
3
)
♦
Ferroptosis
(
3
)
♦
Casein Kinase
(
4
)
♦
NAMPT
(
3
)
Neuronal Signaling
♦
5-HT Receptor
(
0
)
♦
COX
(
40
)
♦
GluR
(
16
)
♦
Adrenergic Receptor
(
0
)
♦
AChR Receptor
(
47
)
♦
Histamine Receptor
(
0
)
♦
Dopamine Receptor
(
0
)
♦
Opioid Receptor
(
0
)
♦
GABA Receptor
(
0
)
♦
P-gp
(
0
)
♦
CaMK
(
8
)
♦
P2 Receptor
(
7
)
♦
OX Receptor
(
0
)
♦
MT Receptor
(
0
)
♦
BACE
(
2
)
♦
Gamma-secretase
(
0
)
♦
Beta Amyloid
(
1
)
Ubiquitin
♦
E2 conjugating
(
1
)
♦
p97
(
3
)
♦
E3 Ligase
(
0
)
♦
DUB
(
8
)
♦
Proteasome
(
0
)
Stem Cells/Wnt
♦
Hedgehog/Smoothened ROCK
(
0
)
♦
ROCK
(
0
)
♦
Wnt/beta-catenin
(
0
)
♦
Gamma-secretase
(
0
)
♦
Casein Kinase
(
0
)
♦
TGF–beta/Smad
(
0
)
♦
STAT
(
9
)
♦
JAK
(
0
)
♦
GSK-3
(
0
)
DNA Damage
♦
Telomerase
(
2
)
♦
Topoisomerase
(
36
)
♦
DNA/RNA Synthesis
(
65
)
♦
HDAC
(
38
)
♦
ATM/ATR
(
14
)
♦
PARP
(
28
)
♦
Sirtuin
(
0
)
GPCR & G Protein
♦
cAMP
(
1
)
♦
Adenosine Receptor
(
4
)
♦
Vasopressin Receptor
(
3
)
♦
CXCR
(
3
)
♦
CaSR
(
2
)
♦
PAFR
(
2
)
♦
CGRP Receptor
(
1
)
♦
LPA Receptor
(
2
)
♦
SGLT
(
4
)
♦
S1P Receptor
(
7
)
♦
Endothelin Receptor
(
7
)
♦
Cannabinoid Receptor
(
7
)
♦
5-HT Receptor
(
63
)
♦
Adrenergic Receptor
(
65
)
♦
Histamine Receptor
(
41
)
♦
Dopamine Receptor
(
28
)
♦
Opioid Receptor
(
9
)
♦
Hedgehog/Smoothened ROCK
(
11
)
♦
OX Receptor
(
7
)
♦
MT Receptor
(
2
)
TGF-beta/Smad
♦
MT Receptor
(
20
)
♦
Bcr-Abl
(
0
)
♦
ROCK
(
20
)
♦
PKC
(
9
)
Cell Cycle
♦
CDK
(
38
)
♦
Rho
(
13
)
♦
PLK
(
10
)
♦
Chk
(
6
)
♦
Aurora Kinase
(
0
)
♦
ROCK
(
0
)
♦
PD-1/PD-L1
(
0
)
♦
c-Myc
(
2
)
♦
Wee1
(
1
)
♦
APC
(
1
)
Cytoskeletal Signaling
♦
Bcr-Abl
(
1
)
♦
Wnt/beta-catenin
(
10
)
♦
PKC
(
1
)
♦
FAK
(
0
)
♦
HSP
(
0
)
♦
Dynamin
(
3
)
♦
PAK
(
3
)
♦
Integrin
(
8
)
♦
Microtubule Associated
(
24
)
♦
Kinesin
(
6
)
Transmembrane
♦
P-gp
(
6
)
♦
Proton Pump
(
10
)
♦
GABA Receptor
(
11
)
♦
Sodium Channel
(
27
)
♦
Potassium Channel
(
16
)
♦
Calcium Channel
(
33
)
♦
ATPase
(
0
)
♦
CRM1
(
1
)
♦
TRPV
(
0
)
♦
CFTR
(
0
)
♦
OCT
(
0
)
Endocrinology & Hormones
♦
Opioid Receptor
(
0
)
♦
Glucocorticoid Receptor
(
5
)
♦
Estrogen/progestogen Receptor
(
34
)
♦
Androgen Receptor
(
13
)
♦
RAAS
(
27
)
♦
Aromatase
(
5
)
♦
GPR
(
5
)
♦
5-alpha Reductase
(
2
)
Microbiology
♦
HCV Protease
(
0
)
♦
HIV Protease
(
0
)
♦
CCR
(
1
)
♦
Reverse Transcriptase
(
27
)
♦
Integrase
(
0
)
Others
♦
gp120/CD4
(
2
)
♦
FXR
(
4
)
♦
PKA
(
2
)
♦
Thrombin
(
4
)
♦
Liver X receptor
(
3
)
♦
IL Receptor
(
0
)
♦
Others 1
(
359
)
♦
Others 2
(
433
)
♦
Others 3
(
331
)
♦
Others 4
(
296
)
♦
Others 5
(
250
)
♦
Others 6
(
287
)
♦
Others 7
(
229
)
New Products
♦
New1
(
29103
)
♦
New2
(
383
)
♦
New3
(
862
)
Product Type
Natural Products
♦
Natural Products 1
(
444
)
Peptides
♦
Peptides 1
(
1998
)
Antibodies
Amino Acids
♦
Amino Acids 1
(
389
)
PROTACs
♦
PROTACs 1
(
40
)
Fine Intermediates/Building Blocks
Others
Dorzolamide HCl
Catalog No：
V0893
CAS No. (CAS Registry Number)：
130693-82-2
Price：
$0/g
Description: Dorzolamide HCl (also known as MK-507, or L-671152 HCl; L671152; MK507; trade name Trusopt) is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 ...
Topiramate
Catalog No：
V0894
CAS No. (CAS Registry Number)：
97240-79-4
Price：
$0/g
Description: Topiramate (also known as MCN 4853, RWJ 17021) is a novel, potent, anticonvulsant (antiepilepsy) drug and is a mutil-targeted inhibitor that has been r...
U-104
Catalog No：
V0895
CAS No. (CAS Registry Number)：
178606-66-1
Price：
$0/g
Description: U-104 (also known as MST-104, SLC-0111 and NSC 213841) is a novel and potent inhibitor of transmembrane carbonic anhydrase (CA) with Ki of 45.1 nM and 4.5 nM for CA IX and CA XII, re...
Tioxolone
Catalog No：
V0896
CAS No. (CAS Registry Number)：
4991-65-5
Price：
$0/g
Description: Tioxolone is a potent metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 NM. Tioxolone is reported to possess cytostatic, antipsoriatic, antibacterial and anti-mycotic propertie...
Methocarbamol
Catalog No：
V0897
CAS No. (CAS Registry Number)：
532-03-6
Price：
$0/g
Description: Methocarbamol (formerly also known as AHR 85) is a potent carbonic anhydrase inhibitor, and is used as a central muscle relaxant to treat skeletal muscle spasms. This compound i...
Brinzolamide
Catalog No：
V0898
CAS No. (CAS Registry Number)：
138890-62-7
Price：
$0/g
Description: Brinzolamide (formerly also known as AL-4862) is a highly potent and selective carbonic anhydrase II inhibitor with IC50 of 3.19 nM. References: Surv Ophthalmol. 2000 ...
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Signaling Pathways
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Services
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Contact Us
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