White blood cells (leukocytes), which are a subset of cytokines (secreted proteins and signaling molecules), were the first to be observed to express interleukins. Interleukins are crucial for the immune system's proper operation, and there have been rare cases of their deficiency that have all been associated with autoimmune disorders or immune deficiencies. Helper CD4 T lymphocytes, along with monocytes, macrophages, and endothelial cells, produce the majority of interleukins. They support the growth and differentiation of hematopoietic cells, including T and B lymphocytes. The development of spatial memories in mice has also been linked to interleukin receptors on astrocytes in the hippocampus.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V106428 | Efarindodekin alfa | Efarindodekin alfa is a fusion protein targeting IL12RB2. | |
|
V134913 | Efbalropendekin alfa | 2736449-62-8 | Efbalropendekin alfa is an IL-15/IL-15 receptor α complex fused with a heterodimeric Fc domain (IL15/IL15Rα-Fc). |
|
V134915 | Efdelikofusp alfa | 2922216-49-5 | Efdelikofusp alfa is a bispecific Fc fusion protein. |
|
V101422 | Efercoleukin alfa | Efercoleukin alfa is an anti-IL2 monoclonal antibody. | |
|
V75000 | Efmarodocokin alfa | 2247840-74-8 | Efmarodocokin alfa is a fusion protein of human IL-22 and the crystallizable fragment of IgG4. |
|
V119783 | Efpixileukin alfa | 2996895-52-2 | Efpixileukin alfa is a fusion protein formed by fusing a human IL-2 variant and a human immunoglobulin G1 (IgG1) Fc fragment at the C-terminus. |
|
V134918 | Eftezirleukin alfa | 3055295-61-6 | Eftezirleukin alfa is a human immunoglobulin G4 (IgG4) Fc fragment. |
|
V134919 | Efzilonkofusp alfa | 2922216-50-8 | Efzilonkofusp alfa is a bispecific Fc fusion protein. |
|
V134981 | EGFR-IN-200 | 3102899-89-5 | EGFR-IN-200 is an inhibitor targeting EGFR, TNF-α, and the IL-6/GP130 complex, exhibiting potent inhibitory activity against human EGFR (IC50=0.03 μM), TNF-α (IC50=3.1 μM), and the IL-6/GP130 complex (IC50=1.6 μM). |
|
V134986 | EGFR-IN-206 | EGFR-IN-206 is an orally effective EGFR inhibitor. | |
|
V105041 | EGR-1-IN-3 | 1700655-93-1 | EGR-1-IN-3 (Compound 36) is an early growth response 1 (EGR-1)-DNA binding disruptor. |
|
V74885 | Elubricin tosylate (SB-656933 tosylate) | 960495-43-6 | Elubbrixin tosylate (SB-656933 tosylate) is a specific, competitive, reversible and orally bioactive CXCR2 antagonist and IL-8 receptor antagonist. |
|
V135078 | ENDO12 | ENDO12 is an inhibitor of the Munc13-4-STX7 protein complex with a Kd value of 2.7 µM for STX7. | |
|
V135134 | ENx-108A | ENx-108A is a human IgG4 monoclonal antibody (mAb) that targets IL-11. | |
|
V135155 | Ephemeranthol A | 135545-86-7 | Ephemeranthol A is a phenanthrene compound with anticancer and anti-inflammatory activities. |
|
V135518 | F8-IL-4 | F8-IL-4 is an immune cytokine that targets IL-4. | |
|
V135807 | FB-825 | FB-825 is a human monoclonal antibody (mAb) that targets IGH. | |
|
V135806 | FB704A | FB704A is a humanized monoclonal anti-IL-6 antibody. | |
|
V119844 | Felcorekibart | 3036134-89-8 | Felcorekibart is a humanized IgG1κ antibody that targets TSLP, with a corresponding isotype control being the human IgG1 kappa isotype control. |
|
V135952 | Firsekibart | 2981430-39-9 | Firsekibart is an IgG4-λ2 monoclonal antibody that targets human interleukin-1β (IL-1β). |
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