White blood cells (leukocytes), which are a subset of cytokines (secreted proteins and signaling molecules), were the first to be observed to express interleukins. Interleukins are crucial for the immune system's proper operation, and there have been rare cases of their deficiency that have all been associated with autoimmune disorders or immune deficiencies. Helper CD4 T lymphocytes, along with monocytes, macrophages, and endothelial cells, produce the majority of interleukins. They support the growth and differentiation of hematopoietic cells, including T and B lymphocytes. The development of spatial memories in mice has also been linked to interleukin receptors on astrocytes in the hippocampus.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V86878 | Docosahexaenoyl serotonin | 283601-58-1 | Docosahexaenoyl serotonin (DHA-5-HT) is an endogenous n-3 fatty acid-serotonin conjugate. |
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V86882 | Donzakimig | Donzakimig is a monoclonal antibody against IL13/IL22/ALB. | |
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V106428 | Efarindodekin alfa | Efarindodekin alfa is a fusion protein targeting IL12RB2. | |
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V101422 | Efercoleukin alfa | Efercoleukin alfa is an anti-IL2 monoclonal antibody. | |
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V74991 | Efineptakin alfa (NT-17) | 2026634-47-7 | Efineptakin alfa (NT-17) is a long-acting recombinant human IL-7. |
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V75000 | Efmarodocokin alfa | 2247840-74-8 | Efmarodocokin alfa is a fusion protein of human IL-22 and the crystallizable fragment of IgG4. |
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V105041 | EGR-1-IN-3 | 1700655-93-1 | EGR-1-IN-3 (Compound 36) is an early growth response 1 (EGR-1)-DNA binding disruptor. |
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V74885 | Elubricin tosylate (SB-656933 tosylate) | 960495-43-6 | Elubbrixin tosylate (SB-656933 tosylate) is a specific, competitive, reversible and orally bioactive CXCR2 antagonist and IL-8 receptor antagonist. |
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V104305 | FKK6 | 2238839-34-2 | FKK6 is a selective agonist of the pregnane X receptor (PXR) with an EC50 of 1.2 µM. |
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V101420 | Galvokimig | Galvokimig is a monoclonal antibody targeting IL13/IL17A/ALB/IL17B. | |
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V74990 | Goflikicept (RPH 104) | 2416984-26-2 | Goflikicept (RPH 104) is a hybrid protein that selectively binds and inactivates circulating IL-1ß and IL-1α. |
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V93756 | GP130 modulator-1 | 2375779-31-8 | GP130 modulator-1 (Compound A33) is a modulator of the GP130 signaling pathway. |
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V106197 | HB-107 | 135154-02-8 | HB-107 is a peptide with wound repair properties that can promote keratinocyte proliferation, increase leukocyte infiltration in the wound, and stimulate cultured endothelial cells to secrete interleukin 8 (IL-8). It is expected to be used in the study of wound healing and inflammation. |
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V75013 | Hedycoronen A | 1383441-73-3 | Hedycoronen A exhibits inhibitory effect on the production of IL-6, IL-12 p40 and TNF-α in LPS-stimulated BMDC, with IC50s of 9.1 μM, 5.6 μM and 46.0 μM, respectively. |
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V87630 | Hidrosmin | 115960-14-0 | Hidrosmin is a flavonoid and a derivative of diosmin. |
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V75032 | IL-17 modulator 1 | 2446803-85-4 | IL-17 modulator 1 is an orally bioactive, highly efficient small molecule IL-17 modulator, found in patent WO 2020127685. |
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V74965 | IL-17 modulator 1 disodium | 2446803-91-2 | IL-17 modulator 1 (disodium) is an orally bioactive, highly efficient small molecule IL-17 modulator, found in patent WO 2020127685. |
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V75010 | IL-17 modulator 2 | 1449208-36-9 | IL-17 modulator 2 (compound 159) is an orally bioactive modulator of IL-17. |
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V74961 | IL-17 modulator 3 | 2467731-88-8 | IL-17 modulator 3 is an IL-17 modulator (US20200247785A1). |
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V74982 | IL-17 modulator 4 sulfate | 2446806-90-0 | IL-17 modulator 4 sulfate is a precursor to IL-17 modulator 1. |
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