White blood cells (leukocytes), which are a subset of cytokines (secreted proteins and signaling molecules), were the first to be observed to express interleukins. Interleukins are crucial for the immune system's proper operation, and there have been rare cases of their deficiency that have all been associated with autoimmune disorders or immune deficiencies. Helper CD4 T lymphocytes, along with monocytes, macrophages, and endothelial cells, produce the majority of interleukins. They support the growth and differentiation of hematopoietic cells, including T and B lymphocytes. The development of spatial memories in mice has also been linked to interleukin receptors on astrocytes in the hippocampus.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V78048 | Anti-neuroinflammation agent 1 | 2968412-77-1 | Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that modulates the polarization of BV2 microglia from the M1 to M2 phenotype. |
|
V106370 | Anti-Rat IL-4 Antibody (OX-81) | Anti-rat IL-4 antibody (OX-81) is an antibody inhibitor against rat IL-4. | |
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V75020 | BAA473 | 27240-87-5 | BAA473 is a bile acid analogue and a potent pyranoid inflammasome activator that induces IL-18 secretion by activating the inflammasome in myeloid and intestinal epithelial cells. |
|
V102547 | Bengamide B | 104947-69-5 | Bengamide B is an inhibitor of NF-κB with IC50 of 85 nM. |
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V86880 | Bizaxofusp | Bizaxofusp is an anti-IL4R monoclonal antibody. | |
|
V106210 | BMP-4 | 1629625-47-3 | BMP-4 is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. In mouse chondrocytes and macrophages, BMP-4 inhibits the expression of inflammatory proteins such as iNOS, COX2, IFN, IL6, etc. in a dose-dependent manner by regulating the iNOS-IFN-IL6 signaling pathway, thereby effectively inhibiting inflammation and alleviating various arthritis symptoms. |
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V67806 | BMS-986251 | 2460133-35-9 | BMS-986251 is an orally bioactive, selective RORγt inverse agonist/activator with EC50 of 12 nM for RORγt GAL4. |
|
V99824 | BRD5075 | BRD5075 is a potent GPR65 activator. | |
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V102668 | C6 D-Threo Ceramide (d18:1/6:0) | 189894-79-9 | C6 D-threoceramide (d18:1/6:0) is a bioactive sphingolipid and cell-permeable ceramide analog. |
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V119623 | Camtarkibart | 3031358-44-5 | Camtarkibart is a humanized anti-IL4R IgG4κ antibody with immunomodulatory activity. |
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V75051 | Casdozokitug (SRF-388) | 2643331-37-5 | Casdozokitug (SRF-388) is an IgG1κ antibody targeting IL27. |
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V74942 | CC-90002 | 2085844-54-6 | CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). |
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V78806 | Citrullinated LL-37 2cit | Citrullinated LL-37 2cit is a citrullinated LL-37 peptide. | |
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V120017 | CSL-360 | CSL-360 is a chimeric, uncoupled IgG1 monoclonal antibody targeting CD123. | |
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V75034 | CTX-471 | 2377152-49-1 | CTX-471 is a fully human monoclonal antibody (mAb) against CD137. |
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V106057 | Cynandione A | 168706-29-4 | Cynandione A is an acetophenone isolated from Cynanchum Wilfordii Radix. |
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V105457 | Cytogenin | 132971-59-6 | Cytogenin (antibiotic MI 43-37F11) is an oral antitumor antibiotic. |
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V106164 | d-(RYTVELA) | 868844-53-5 | d-(RYTVELA) is a specific inhibitor of human thymocyte proliferation with IC50 of 1 nM. |
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V98531 | Dactyllactone A | 2226393-57-1 | Dactyllactone A is an isoquinoline alkaloid isolated from Dactylicapnos scandens. |
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V102514 | Denotivir | 51287-57-1 | Denotivir (Vratizolin) is an oral antiviral drug that can treat herpes simplex virus (HSV) and varicella-zoster virus (VZV). |
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