A protein with two distinct functions, -catenin controls both the coordination of gene transcription and cell-cell adhesion. The CTNNB1 gene in humans encodes the CTNNB1 protein. In the Wnt signaling pathway, -catenin functions as an intracellular signal transducer as a subunit of the cadherin protein complex.It is a homolog of -catenin and a member of the catenin protein family. Hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian, and endometrial cancer are just a few of the cancers that have been linked to mutations and overexpression of -catenin. The beta-catenin destruction complex, and in particular the adenomatous polyposis coli (APC) protein, which is encoded by the tumor-suppressing APC gene, regulates and annihilates -catenin. As a result, genetic APC gene mutation is strongly associated with cancers, particularly colorectal cancer brought on by familial adenomatous polyposis (FAP).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V136657 | GlcCer (d18:1/18:0) | 95119-86-1 | GlcCer (d18:1/18:0) is a glycosphingolipid that activates the Wnt/β-catenin signaling pathway by targeting LRP6. |
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V136967 | GSK-3β inhibitor 24 | 3069913-37-4 | GSK-3β inhibitor 24 is a potent GSK-3β inhibitor with an IC50 value of 0.22 nM. |
|
V78739 | hCA/Wnt/β-catenin-IN-1 | hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor (blocker/antagonist) of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). | |
|
V137316 | Herpetin | 911052-87-4 | Herpetin is an active lignan. |
|
V80395 | IR-251 | IR-251 is a mitochondria-targeted near-infrared fluorescent probe. | |
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V138542 | KWZY-11 | 3077131-44-0 | KWZY-11 is a potent dual PARP/CDK6 inhibitor with IC50 values of 156.8 nM, 197.3 nM, and 13.3 nM for PARP1, PARP2, and CDK6, respectively. |
|
V67517 | KY1022 | 1029721-36-5 | KY1022 is a small molecule that destabilizes Ras by targeting the Wnt/β-catenin pathway. |
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V139049 | LP-935001 | 1875037-24-3 | LP-935001 is a Notum carboxylesterase inhibitor with an IC50 of 0.4 nM. |
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V51021 | Miclxin (DS-37262926) | 2494198-61-5 | Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involved in Wnt signaling. |
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V140508 | Multitarget AD-IN-7 | 3113741-59-3 | Multitarget AD-IN-7 is an orally effective multitarget compound for treating Alzheimer's disease. |
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V140517 | Murayaquinone | 100843-91-2 | Murayaquinone is a β-catenin/Tcf4 complex inhibitor with an IC50 of 2.4 μM. |
|
V67510 | Nefopam-d3 hydrochloride (Fenazoxine-d3 (hydrochloride)) | 1346603-30-2 | Nefopam-d3 ( HCl) is the deuterated form of Nefopam HCl. |
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V88156 | NF764 | NF764 is a potent β-catenin (CTNNB1) degrader. | |
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V80955 | NLS-StAx-h TFA | NLS-StAx-h TFA is a selective, cell-permeable (penetrable), immobilized peptide inhibitor of Wnt signaling with IC50 of 1.4 μM. | |
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V67503 | NRX-103094 | 2763260-36-0 | NRX-103094 is a potent enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP, enhancing the binding of pSer33/Ser37 β-catenin and β-TrCP with EC50 of 62 nM and a Kd of 0.6 nM. |
|
V67506 | NRX-103095 | 2763260-38-2 | NRX-103095 is an enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP. |
|
V67505 | NRX-252114 | 2763260-39-3 | NRX-252114 is a potent enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP, enhancing the binding of pSer33/S37A β-catenin and β-TrCP with EC50 of 6.5 nM and a Kd of 0.4 nM. |
|
V69186 | NRX-252262 | 2438637-61-5 | NRX-252262 is a potent enhancer of the interaction between β-Catenin and the homologous E3 ligase SCFβ-TrCP, which can promote the degradation of β-catenin with EC50 of 3.8 nM. |
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V67507 | NRX-2663 | 2763260-34-8 | NRX-2663 is an enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP, enhancing the binding of β-catenin to β-TrCP with EC50 of 22.9 µM and a Kd of 54.8 nM. |
|
V109677 | Picrasidine J | 100234-62-6 | Piracetam J is a selective inhibitor that targets the KLK-10 protease and the ERK signaling pathway. |
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