Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V82534	A 410099.1 amide-PEG3-amine-Boc	2415256-19-6	A 410099.1 amide-PEG3-amine-Boc is a functionalized IAP ligand for PROTAC, which combines an IAP ligand and an amide-PEG3 linker with an amide at the end, which can bind to the target protein ligand.
V104617	Acepromazine-OTs	102951-20-2	Acepromazine-OTs is a cereblon (CRBN) ligand that recruits CRBN protein.
V82535	Acid-PEG2-ethyl propionate	886362-90-9	Acid-PEG2-ethyl propionate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82570	Acid-PEG25-NHSester	2563872-17-1	Acid-PEG25-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82573	Acid-PEG7-t-butyl ester	2134235-86-0	Acid-PEG7-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82567	Amino-PEG16-acid	2922656-52-6	Amino-PEG16-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V114824	APYIP	882415-28-3	APYIP is a ligand for E3 ubiquitin ligase.
V109557	Arg12	105151-62-0	Arg12 is a polypeptide sequence consisting of 12 arginine residues and is an E3 ubiquitin ligand.
V104264	AS1411-C4-VH032		AS1411-C4-VH032 (AS1411-VH032) promotes tumor-selective degradation of MDM2, resulting in tumor shrinkage without detectable toxicity.
V87934	Aster-A Ligand-3	2375541-28-7	Aster-A Ligand-3 is a target protein ligand that can be used to synthesize PROTAC Aster-A degraders.
V82599	Azido-PEG10-Boc	2490419-48-0	Azido-PEG10-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V82578	Azido-PEG12-alcohol	1111239-69-0	Azido-PEG12-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82538	Azido-PEG3-chloroacetamide	604766-23-6	Azido-PEG3-chloroacetamide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82550	Azido-PEG3-MS	176520-24-4	Azido-PEG3-MS is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82581	Azido-PEG7-t-butyl ester	2596867-40-0	Azido-PEG7-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82566	Azido-PEG9-S-methyl ethanethioate	2148986-33-6	Azido-PEG9-S-methyl ethanethioate is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V87929	Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph		Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph is a ligand for E3 ubiquitin ligase.
V82565	Benzyl-PEG24-alcohol	2218463-19-3	Benzyl-PEG24-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82592	Benzyl-PEG3-amine	86770-75-4	Benzyl-PEG3-amine is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82588	Benzyl-PEG6-MS	1262681-32-2	Benzyl-PEG6-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.