Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V125299	3-Azathalidomide	31804-66-7	3-Azathalidomide is a thalidomide analogue that can be used in PROTAC studies.
V126098	4-[(1E)-2-Nitroethenyl]benzoic acid	821797-33-5	4-[(1E)-2-Nitroethenyl]benzoic acid is an E3 ligand.
V82543	4-Boc-amino-2,2-dimethylbutyric acid	153039-17-9	4-Boc-amino-22-dimethylbutyric acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.
V113098	4-Br-7-O-Desamino lenalidomide	2438241-00-8	4-Bromo-7-O-deaminolenalidomide is the E3 ubiquitin ligand of cereblon (CRBN) and is used to recruit cereblon protein.
V126318	4-Chloro-3-(2,4-dioxo-1,3-diazinan-1-yl)benzoic acid	2377645-90-2	4-Chloro-3-(2,4-dioxo-1,3-diazinan-1-yl)benzoic acid is an E3 ligase ligand that can be used to recruit CRBN protein.
V126430	4-Me-Thalidomide	244057-31-6	4-Me-Thalidomide is a methyl-containing E3 ubiquitin ligase activator.
V83736	4-Methylanisole-dihydrouracil-imidazo[1,2-a]pyridine-piperidine-NH-Boc
V113492	5,6-Difluoro-desamino lenalidomide	2438241-40-6	5,6-Difluorodeaminyllenalidomide is the E3 ubiquitin ligand for cereblon (CRBN) and is used to recruit cereblon proteins.
V126558	5-(2-Chloroacetamide) thalidomide	1957235-51-6	5-(2-Chloroacetamide) thalidomide is an analogue of thalidomide.
V82524	5-(Biotinamido)pentylazide	1349190-76-6	5-Biotinamidopentylazide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl chain class, may be utilized to prepare PROTAC molecules.
V112787	5-Br-6-F-Desamino lenalidomide	2409005-96-3	5-Br-6-F-deaminolenalidomide is the E3 ubiquitin ligand for cereblon (CRBN) and is used to recruit cereblon proteins.
V126918	5-Bromomethylthalidomide	1312023-72-5	5-Bromomethylthalidomide is an E3 ligase activator that can be further derivatized by bromide substitution.
V113400	5-Fluoro-lenalidomide	1918158-58-3	5-Fluorenalidomide is the E3 ubiquitin ligand of cereblon (CRBN) and can recruit cereblon proteins.
V112761	5-Fluoro-pomalidomide	2713422-01-4	5-Fluoropomalidamine is the E3 ubiquitin ligand of cereblon (CRBN) and can recruit cereblon proteins.
V127023	5-Hydrazinyl thalidomide hydrochloride	2803460-96-8	5-Hydrazinyl thalidomide hydrochloride is a thalidomide analog containing a hydrazine group.
V127030	5-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione	2589697-74-3	5-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione is a thalidomide analogue containing a hydroxyl group in its structure, which is an ideal site for further derivatization.
V127134	5-Norbornene-2-methylamine	95-10-3	5-Norbornene-2-methylamine is a hydrophobic label.
V119790	6-(2,4-Dioxopyrimidin-1-yl)-1-methylindole	2766178-76-9	6-(2,4-dioxanil-1-yl)-1-methylindole is an E3 ligase ligand that can be used to synthesize PROTAC androgen receptor degrader-1.
V113443	7-F-4-I-Desamino lenalidomide	2207569-51-3	7-F-4-I-deaminolenalidomide is the E3 ubiquitin ligand for cereblon (CRBN) and is used to recruit cereblon protein.
V82556	A 410099.1 amide-PEG2-amine-Boc	2415256-16-3	410099.1 amide-PEG2-amine-Boc is a functionalized IAP ligand for PROTAC, which combines an IAP ligand and an amide-PEG2 linker with an amide terminal to bind to the target protein ligand.