Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V118359	(S,S,S)-VH032	2097602-09-8	(S,S,S)-VH032 is a ligand for E3 ligase (VHL) and can be used to synthesize PROTAC SGK3 degrader-2.
V119360	(S,S,S)-VH032-cyclopropane-F	2306193-95-1	(S,S,S)-VH032-cyclopropane-F is an E3 ubiquitin ligand.
V119502	1-(4-Pip-Ph)-DHP-dione	2446913-96-6	1-(4-Pip-Ph)-DHP-dione is an E3 ligand ligand.
V109164	2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe	26581-83-9	2-(2,6-dioxadiazine-3-yl)phthalimide NMe is the E3 ligase ligand of SIAIS630121-NC.
V3589	E3 ligase Ligand 2	5054-59-1	Thalidomide-4-OH (Cereblon ligand 2) is a Thalidomide-based Cereblon ligand that recruits CRBN protein.
V87925	2-Methoxyphenyl dihydrouracil	2377643-33-7	2-Methoxyphenyl dihydrouracil (Compound 13) is a CRBN ligand that can be used to synthesize PROTACs.
V82543	4-Boc-amino-2,2-dimethylbutyric acid	153039-17-9	4-Boc-amino-22-dimethylbutyric acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.
V113098	4-Br-7-O-Desamino lenalidomide	2438241-00-8	4-Bromo-7-O-deaminolenalidomide is the E3 ubiquitin ligand of cereblon (CRBN) and is used to recruit cereblon protein.
V83736	4-Methylanisole-dihydrouracil-imidazo[1,2-a]pyridine-piperidine-NH-Boc
V113492	5,6-Difluoro-desamino lenalidomide	2438241-40-6	5,6-Difluorodeaminyllenalidomide is the E3 ubiquitin ligand for cereblon (CRBN) and is used to recruit cereblon proteins.
V82524	5-(Biotinamido)pentylazide	1349190-76-6	5-Biotinamidopentylazide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl chain class, may be utilized to prepare PROTAC molecules.
V112787	5-Br-6-F-Desamino lenalidomide	2409005-96-3	5-Br-6-F-deaminolenalidomide is the E3 ubiquitin ligand for cereblon (CRBN) and is used to recruit cereblon proteins.
V113400	5-Fluoro-lenalidomide	1918158-58-3	5-Fluorenalidomide is the E3 ubiquitin ligand of cereblon (CRBN) and can recruit cereblon proteins.
V112761	5-Fluoro-pomalidomide	2713422-01-4	5-Fluoropomalidamine is the E3 ubiquitin ligand of cereblon (CRBN) and can recruit cereblon proteins.
V119790	6-(2,4-Dioxopyrimidin-1-yl)-1-methylindole	2766178-76-9	6-(2,4-dioxanil-1-yl)-1-methylindole is an E3 ligase ligand that can be used to synthesize PROTAC androgen receptor degrader-1.
V113443	7-F-4-I-Desamino lenalidomide	2207569-51-3	7-F-4-I-deaminolenalidomide is the E3 ubiquitin ligand for cereblon (CRBN) and is used to recruit cereblon protein.
V82556	A 410099.1 amide-PEG2-amine-Boc	2415256-16-3	410099.1 amide-PEG2-amine-Boc is a functionalized IAP ligand for PROTAC, which combines an IAP ligand and an amide-PEG2 linker with an amide terminal to bind to the target protein ligand.
V82534	A 410099.1 amide-PEG3-amine-Boc	2415256-19-6	A 410099.1 amide-PEG3-amine-Boc is a functionalized IAP ligand for PROTAC, which combines an IAP ligand and an amide-PEG3 linker with an amide at the end, which can bind to the target protein ligand.
V104617	Acepromazine-OTs	102951-20-2	Acepromazine-OTs is a cereblon (CRBN) ligand that recruits CRBN protein.
V82535	Acid-PEG2-ethyl propionate	886362-90-9	Acid-PEG2-ethyl propionate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.