Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V112928	(S,R,S)-AHPC-PEG5-Azide	3036242-05-1	(S,R,S)-AHPC-PEG5-azide is a (S,R,S)-AHPC-based VHL ligand that recruits the von Hippel-Lindau (VHL) protein.
V4063	(S,R,S)-AHPC hydrochloride	1448189-80-7	Protein degrader 1 HCl (hydrochloride) or PROTAC-VHL-ligandis a novel and potent small molecule ligand forVHL (Von Hippel-Lindau), which is anE3 ligasewhich has been targeted in many PROTAC (proteolysis-targeting chimeras) degraders.
V93639	(S,R,S,R)-AHPC-Me	2055344-67-5	(S,R,S,R)-AHPC-Me acts as a VHL ligand and promotes the recruitment of VHL protein.
V119518	(S,S,S)-AHPC	1797406-78-0	(S,S,S)-AHPC is an E3 ligase ligand.
V120327	(S,S,S)-AHPC-Me	2380273-25-4	(S,S,S)-AHPC-Me is an E3 ligase ligand.
V118359	(S,S,S)-VH032	2097602-09-8	(S,S,S)-VH032 is a ligand for E3 ligase (VHL) and can be used to synthesize PROTAC SGK3 degrader-2.
V119360	(S,S,S)-VH032-cyclopropane-F	2306193-95-1	(S,S,S)-VH032-cyclopropane-F is an E3 ubiquitin ligand.
V119502	1-(4-Pip-Ph)-DHP-dione	2446913-96-6	1-(4-Pip-Ph)-DHP-dione is an E3 ligand ligand.
V123788	2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione	959150-64-2	2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione is a derivative of thalidomide with an iodine atom on its benzyl ring.
V123789	2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione	2154356-63-3	2-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione is a thalidomide analogue that can be used in PROTAC studies.
V109164	2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe	26581-83-9	2-(2,6-dioxadiazine-3-yl)phthalimide NMe is the E3 ligase ligand of SIAIS630121-NC.
V3589	E3 ligase Ligand 2	5054-59-1	Thalidomide-4-OH (Cereblon ligand 2) is a Thalidomide-based Cereblon ligand that recruits CRBN protein.
V87925	2-Methoxyphenyl dihydrouracil	2377643-33-7	2-Methoxyphenyl dihydrouracil (Compound 13) is a CRBN ligand that can be used to synthesize PROTACs.
V124953	3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione	2923549-60-2	3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione is a CRBN-type E3 ubiquitin ligand ligand that can be used to prepare PROTAC.
V124954	3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione	2924092-66-8	3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione is a CRBN-type E3 ubiquitin ligand ligand that can be used to prepare PROTAC.
V124965	3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione	2990057-63-9	3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione is a CRBN-type E3 ubiquitin ligand ligand that can be used to prepare PROTAC.
V124967	3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione	191732-74-8	3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a lenalidomide analog that can be used in PROTAC studies because it is suitable for recruiting CRBN proteins.
V124968	3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione	2304513-76-4	3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a lenalidomide analogue that can be used in PROTAC studies.
V124969	3-(7-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione	191732-75-9	3-(7-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a lenalidomide analogue that can be used in PROTAC studies.
V124970	3-(7-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione	2229976-08-1	3-(7-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a lenalidomide analogue that can be used in PROTAC studies.