A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.
E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V113717 | (S,R,S)-AHPC 2-OH hydrochloride | 2244684-41-9 | (S,R,S)-AHPC 2-OH hydrochloride is an E3 ubiquitin ligand that can be used to recruit VHL proteins. |
|
V85210 | (S,R,S)-AHPC dihydrochloride (VH032-NH2 dihydrochloride; VHL ligand 1 dihydrochloride) | 2137142-47-1 | |
|
V89049 | (S,R,S)-AHPC(Me)-amido-C2-acid | 2365173-01-7 | (S,R,S)-AHPC(Me)-amido-C2-acid is a VHL (E3 ligase) ligand that can be used to synthesize PROTACs, such as PROTAC STING Degrader-2. |
|
V97362 | (S,R,S)-AHPC-Ac | 2361116-63-2 | (S,R,S)-AHPC-Ac is a ligand for E3 ubiquitinases. |
|
V83764 | (S,R,S)-AHPC-acetyl-azetidine-PIP-boc | ||
|
V83721 | (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc | ||
|
V97267 | (S,R,S)-AHPC-Ala | 2641319-58-4 | (S,R,S)-AHPC-Ala is a ligand for E3 ubiquitinase. |
|
V113398 | (S,R,S)-AHPC-amide-C10-azide | 2906183-85-3 | (S,R,S)-AHPC-amide-C10-azide is an E3 ubiquitin ligand and also a VHL ligand used to recruit VHL proteins. |
|
V82564 | (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) | 2086301-47-3 | (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a ligand (for E3 ligase)-linker conjugate ( E3 ligase ligand-linker conjugate), containing VHL ligand. |
|
V82555 | (S,R,S)-AHPC-C10-NHBoc | 2412055-13-9 | (S,R,S)-AHPC-C10-NHBoc is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)-AHPC (HY -125845) VHL ligand and 1 linker. |
|
V82542 | (S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) | 2597167-24-1 | (S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)- AHPC's VHL ligand and 4-unit PEG linker. (S,R,S)-AHPC-C2-PEG4-N3 may be utilized in the synthesis/preparation of vRucaparib-TP4 . |
|
V83795 | (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH | ||
|
V83777 | (S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc | ||
|
V83759 | (S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc | ||
|
V2400 | (S,R,S)-AHPC-Me | 1948273-02-6 | S,R,S)-AHPC-Me (also known as VHL ligand 2 or E3 ligase Ligand 1A) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. |
|
V122250 | (S,R,S)-AHPC-Me-C8-NHS ester | (S,R,S)-AHPC-Me-C8-NHS ester is an E3 ubiquitin ligand VHL ligand used to recruit VHL proteins. | |
|
V122252 | (S,R,S)-AHPC-Me-NHBoc | 1997302-16-5 | (S,R,S)-AHPC-Me-NHBoc is an E3 ubiquitin ligand VHL ligand used to recruit VHL proteins. |
|
V112789 | (S,R,S)-AHPC-Me-PEG3-azide | (S,R,S)-AHPC-Me-PEG3-azide is a (S,R,S)-AHPC-based VHL ligand that recruits the von Hippel-Lindau (VHL) protein. | |
|
V97277 | (S,R,S)-AHPC-O-CF3 | 2641373-92-2 | (S,R,S)-AHPC-O-CF3 is a ligand for E3 ubiquitinase. |
|
V113096 | (S,R,S)-AHPC-PEG2-SH | (S,R,S)-AHPC-PEG2-SH is a (S,R,S)-AHPC-based VHL ligand that recruits the von Hippel-Lindau (VHL) protein. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
